ID A0A383S5N7_9ACTN Unreviewed; 459 AA.
AC A0A383S5N7;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=L-lysine N6-monooxygenase MbtG {ECO:0000256|ARBA:ARBA00016406};
DE EC=1.14.13.59 {ECO:0000256|ARBA:ARBA00013076};
DE AltName: Full=Lysine 6-N-hydroxylase {ECO:0000256|ARBA:ARBA00032738};
DE AltName: Full=Lysine N6-hydroxylase {ECO:0000256|ARBA:ARBA00032493};
DE AltName: Full=Lysine-N-oxygenase {ECO:0000256|ARBA:ARBA00029939};
DE AltName: Full=Mycobactin synthase protein G {ECO:0000256|ARBA:ARBA00031158};
GN ORFNames=D7U36_03545 {ECO:0000313|EMBL:RLP11950.1}, PROPAUS_0472
GN {ECO:0000313|EMBL:SYZ32586.1};
OS Propionibacterium australiense.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Propionibacterium.
OX NCBI_TaxID=119981 {ECO:0000313|EMBL:SYZ32586.1, ECO:0000313|Proteomes:UP000263928};
RN [1] {ECO:0000313|EMBL:SYZ32586.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Propionibacterium_australiense1 {ECO:0000313|EMBL:SYZ32586.1};
RA Ferrada E.E., Latorre B.A.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000263928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hornung B.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:RLP11950.1, ECO:0000313|Proteomes:UP000279336}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NML98A078 {ECO:0000313|EMBL:RLP11950.1,
RC ECO:0000313|Proteomes:UP000279336};
RA Bernier A.-M., Bernard K.;
RT "Propionibacterium australiense Genome Sequencing and Assembly.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+);
CC Xref=Rhea:RHEA:23228, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:32551, ChEBI:CHEBI:57783, ChEBI:CHEBI:57820,
CC ChEBI:CHEBI:58349; EC=1.14.13.59;
CC Evidence={ECO:0000256|ARBA:ARBA00000168};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; RCIW01000004; RLP11950.1; -; Genomic_DNA.
DR EMBL; UNQJ01000002; SYZ32586.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A383S5N7; -.
DR OrthoDB; 9149460at2; -.
DR Proteomes; UP000263928; Unassembled WGS sequence.
DR Proteomes; UP000279336; Unassembled WGS sequence.
DR GO; GO:0047091; F:L-lysine 6-monooxygenase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR025700; Lys/Orn_oxygenase.
DR Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Monooxygenase {ECO:0000313|EMBL:SYZ32586.1};
KW Oxidoreductase {ECO:0000313|EMBL:SYZ32586.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000263928}.
FT REGION 431..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 459 AA; 49564 MW; CDAEFCC6D49F7A5A CRC64;
MASLVVVGAG PKAVAVQAKA HALRRLGMTI PEIQVVDPIG VAGNWLPEGG WTDGRHLLGT
SPFKDIGFPY RTRIADDPPP HPEIADTRGP LSRAVDRELL TLSWVRFLIE TGRYASWIDR
CQPQPQHRLW AEYLRWVAAR TGLDLVRGRV TGMHAGAEGW SLSVCMTDGR VRTVTADALL
VTGPGPSTHR IAEIPRVLSL AGFWKAIADD ELPESSRIAV IGAGESAASV ITEVIRHDVD
EICLVSPAAT VFSRGEGRFE NAMYTDPRRW ADLDEQARRD FIARTDRGVI SVGMQDCLSS
DDRVAHLRGR VLEARDTASG VELTMTDPAR GHRTATFGLV IDARGGSPVW FTELMDPQTR
SLVSAACGGE LTARCFEDRM TPTLALADLA PTLFVPALSG FRQGPGFANL SCLGELSDRI
LAGIGVGRLP ESSPAARPGQ LPHGMKNPRT HPARGFSTA
//
