ID A0A383TZL3_9FLAO Unreviewed; 730 AA.
AC A0A383TZL3;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=recQ_1 {ECO:0000313|EMBL:SZD73054.1};
GN ORFNames=SAMEA104719789_01136 {ECO:0000313|EMBL:SZD73054.1};
OS Candidatus Ornithobacterium hominis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Ornithobacterium.
OX NCBI_TaxID=2497989 {ECO:0000313|EMBL:SZD73054.1, ECO:0000313|Proteomes:UP000262142};
RN [1] {ECO:0000313|EMBL:SZD73054.1, ECO:0000313|Proteomes:UP000262142}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OH-22767 {ECO:0000313|EMBL:SZD73054.1,
RC ECO:0000313|Proteomes:UP000262142};
RG Pathogen Informatics;
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR EMBL; UNSC01000004; SZD73054.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A383TZL3; -.
DR OrthoDB; 9763310at2; -.
DR Proteomes; UP000262142; Unassembled WGS sequence.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 1.10.10.1390; ATP-dependent DNA helicase RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR048671; RecQ-1-like_HTH.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF21220; RecQ-1-like_HTH; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:SZD73054.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:SZD73054.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000262142}.
FT DOMAIN 28..199
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 220..365
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 532..612
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
SQ SEQUENCE 730 AA; 83276 MW; B6B81D10607A3DBF CRC64;
MTIKTNLQAE LKKYFGFDQF KNLQENIIQN LLDGNDVFVL MPTGGGKSLC YQLPALIQDG
CAIIISPLIA LMKNQVDAIR GISENDAVAH VLNSSLTKTE IKKVLSDIEN GATKLLYVAP
ESLTKEEYTE FFKGVKISFF AIDEAHCISE WGHDFRPEYR NLKSIIEKIG DFPIIALTAT
ATPKVQEDIQ KTLGMTDAVL FKASFNRPNL FYEVRPKVDV DKQIIKFIHE RKGKSGIVYC
LSRKKVEEFA QTLQLNGINA IPYHAGLDSK TRAEHQDKFL MEEVDVVVAT IAFGMGIDKP
DVRFVIHYDF PKSLEGYYQE TGRAGRDGGE GYCLAFYDYK DIEKLEKFLS GKPVSEREVG
MQLLNEVVAY AETAMSRRKY LLHYFGEDFD EIHGEGADMD DNMRSPKKLT EAKDELLQIL
KVIKETNSKL KLKDLIKVML GQENIITKSY GLQDAEFFGS GRDYSEFFWK ALLRQALISG
YLEKEIETYG IISLTQKGKS FIQKPVSFKI IEDHDYENLL NVSFDGDKKN SAILDENLYK
DLLQLRKKIA KKHGIPPFAV FQESSLEDMA LQYPTSIEDL TKVYGVGEGK AKKFGEDFVT
YIAKYVEENE IETPDDFIVK QIANKSTNKV YIIQSTDRKM DFEDIANAKG MSMDELLSEM
ESIVYQGTKI NISYYINEMI DEDLQEEVMD FLMKDAEDDS MKTLLEEFGD ELEDEELRLM
RIKFISEVAN
//
