ID A0A383VJT7_TETOB Unreviewed; 724 AA.
AC A0A383VJT7;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN ORFNames=BQ4739_LOCUS5399 {ECO:0000313|EMBL:SZX64924.1};
OS Tetradesmus obliquus (Green alga) (Acutodesmus obliquus).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Sphaeropleales; Scenedesmaceae; Tetradesmus.
OX NCBI_TaxID=3088 {ECO:0000313|EMBL:SZX64924.1, ECO:0000313|Proteomes:UP000256970};
RN [1] {ECO:0000313|EMBL:SZX64924.1, ECO:0000313|Proteomes:UP000256970}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Cai Z.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
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DR EMBL; FNXT01000505; SZX64924.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A383VJT7; -.
DR STRING; 3088.A0A383VJT7; -.
DR Proteomes; UP000256970; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000256970};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 36..724
FT /note="Nicastrin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016780969"
FT TRANSMEM 696..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..224
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
SQ SEQUENCE 724 AA; 76690 MW; D2D4DA70A8F1EE86 CRC64;
MASAVHSNLA AHVLLRVWLF GLSVHLLATS QAVQSKSLED IGLVTTVKAL SEVMYREMKQ
TGGCYKLLNA TGPVGSQGDP DYNLDIDAPL VHASDLQQPL QRDVAVLLPV KQSVAFMQQL
QGSPEMQQHI KGLLFDDTDP PASYSTVGPF PGGPEYAPYN APSYVWNKAA GANSYPFASS
WFPMPVFLLT PELAADAQQR AAYNAKQDPT RKQYHARMKL AMAAATSANS ADCISQGTCK
PLGGYSVWAA LPPLPAAAAA AGAAGDDGRP IILVVAQMDS IDMFHDSVQG ADGPLSGLVS
MLTALHALHS SFTNSSSSSS SYSKRIVFMA LAGEPWGYMG SRRLLWEAAS GSNSTAGLNM
SLVEQVIEVG QGGRLTASPA ANAPLKLYAH SQQGPGFGNS SSMLAALQAA AQGEASSAKA
DVLAASPSNP GIPPSSLMSF LRVKPSIQGL VLAEFDDGFI NPYFGSRFDN GSTVNADGIA
SVAAVLAAAV HRLAGGEPAA LKVNMTELQQ VAASYAACII MPTPGFACPT AAAIMAPDYT
VSTGSATRSY APRNYIGVLQ YMPEVQAPLG KSNLARFVWN LMAFDSSDGA FGQACDHWKR
RCQEGQVCAG WRSSSDEELM GRCVNATVRY VPSYSTRVSC ESCSDYYTAK WQLTDVAEQW
SQQYSWPDDP LWAESDWPVG VPDLQLYLHE AEAVEVALLV SGLLVTVAVG VASLAAKAAF
HRHH
//