ID A0A383VR83_TETOB Unreviewed; 958 AA.
AC A0A383VR83;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=DNA ligase (NAD(+)) {ECO:0000256|ARBA:ARBA00012722};
DE EC=6.5.1.2 {ECO:0000256|ARBA:ARBA00012722};
GN ORFNames=BQ4739_LOCUS7326 {ECO:0000313|EMBL:SZX66896.1};
OS Tetradesmus obliquus (Green alga) (Acutodesmus obliquus).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Sphaeropleales; Scenedesmaceae; Tetradesmus.
OX NCBI_TaxID=3088 {ECO:0000313|EMBL:SZX66896.1, ECO:0000313|Proteomes:UP000256970};
RN [1] {ECO:0000313|EMBL:SZX66896.1, ECO:0000313|Proteomes:UP000256970}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Cai Z.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=NAD(+) + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + beta-
CC nicotinamide D-nucleotide.; EC=6.5.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00034005};
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DR EMBL; FNXT01000763; SZX66896.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A383VR83; -.
DR STRING; 3088.A0A383VR83; -.
DR Proteomes; UP000256970; Unassembled WGS sequence.
DR GO; GO:0003911; F:DNA ligase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00114; LIGANc; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 1.10.287.610; Helix hairpin bin; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR HAMAP; MF_01588; DNA_ligase_A; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR001679; DNA_ligase.
DR InterPro; IPR018239; DNA_ligase_AS.
DR InterPro; IPR013839; DNAligase_adenylation.
DR InterPro; IPR013840; DNAligase_N.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR004150; NAD_DNA_ligase_OB.
DR InterPro; IPR010994; RuvA_2-like.
DR NCBIfam; TIGR00575; dnlj; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF01653; DNA_ligase_aden; 1.
DR Pfam; PF03120; DNA_ligase_OB; 1.
DR SMART; SM00532; LIGANc; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS01055; DNA_LIGASE_N1; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000256970};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 196..686
FT /note="NAD-dependent DNA ligase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00532"
FT REGION 124..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 365..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 958 AA; 100351 MW; 56A559AE3D10C808 CRC64;
MLVSAGARCA PGAAGAVVAA LRCLSSSQLL ASCSTSLDNQ QHVPAVPSAG YQQQQQQQQQ
QQQQSYAAAA CLQQRPCADA CCSCRQQGPF QLLPAAQRQL AAAAAAAQHT RACSTGVFVA
AASAGATSRS RSRSRRAGAT TTAEQDGDAA AAAAAAAAAA AAAAKPSSRS RRSRAPAAPQ
PAAALQTTAD AAAVPALTQQ AAELVNRLNS YCEAYYNGPQ PLISDAEYDA QLRLLQQLLA
QLRSCGQREE AQELEQRSPL RRVGAPLSAV TALSKVTHPT PMTSLAAVRD EDELRAWGSR
LAKQGVVNPE AVDWVVEPKV DGLAVRVVYR DGRLALAATR GDGTQGEDVT HNAATGAIQG
LPLSLAGSSS SSSSNGNGNG GMLQLPSEVE VRGEVFMTTT DFEQLNAQQV AAGQAGFANP
RNAAAGSLRL LDAGEAAGRR LSFRAYQLLL PQGTSGAPTS QAGCLAWLEQ HGVTTTATRA
AQGLDGHATW QGFEAAVAAA GRWMQQRERL DYDVDGVVLK VNDLDLQEEA GVDAGRDPRW
AVAWKFPAKL ATTRILGIEW SVGRSGVLTP VARLETVQIG GVNVSNASLH NVGQLRALGL
VQGDMVTVKR AGDVIPQVVG CLLEARDPLT SAQEPFPEPT HCPSCTQPLT FVEPKTRNAK
GHLWCSNPAC PAQQLGRMKH FVDVCVKGIG GATVEALWER GWLPNPAGLY KLTQADLMTL
PAVKERKSAK MLAAIEASRA MPLKMLLAGL AIADVGERQA ANLATKYKTM KRLQLAANGT
APSSSSSSSS NPAAAADPEI SGVLGASLAA WFADAHNKLL LNELREAGVA VCQEDPAAAE
LVAEDGLSAA TIDVPGSIPG ISGPGQNDVE ALSGVSVCVT GKCRRKVLES RYLQEGYIQE
KGGEFHKAVK KSTTWLLVGD KPGQNKVEAA AKYGTRTLSE EEFFAEIEKL TLQKQGYM
//
