ID A0A383VRS7_TETOB Unreviewed; 1095 AA.
AC A0A383VRS7;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0000259|PROSITE:PS50238};
GN ORFNames=BQ4739_LOCUS8216 {ECO:0000313|EMBL:SZX67871.1};
OS Tetradesmus obliquus (Green alga) (Acutodesmus obliquus).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Sphaeropleales; Scenedesmaceae; Tetradesmus.
OX NCBI_TaxID=3088 {ECO:0000313|EMBL:SZX67871.1, ECO:0000313|Proteomes:UP000256970};
RN [1] {ECO:0000313|EMBL:SZX67871.1, ECO:0000313|Proteomes:UP000256970}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Cai Z.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane
CC {ECO:0000256|ARBA:ARBA00004580}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004146}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the inositol polyphosphate 5-phosphatase family.
CC {ECO:0000256|ARBA:ARBA00010768}.
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DR EMBL; FNXT01000816; SZX67871.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A383VRS7; -.
DR STRING; 3088.A0A383VRS7; -.
DR Proteomes; UP000256970; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:InterPro.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR045849; IP5P_plant.
DR InterPro; IPR000300; IPPc.
DR InterPro; IPR048869; OCRL-1_2_ASH.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR45666:SF22; TYPE IV INOSITOL POLYPHOSPHATE 5-PHOSPHATASE 7; 1.
DR PANTHER; PTHR45666; TYPE IV INOSITOL POLYPHOSPHATE 5-PHOSPHATASE 9; 1.
DR Pfam; PF21310; OCRL-like_ASH; 1.
DR SMART; SM00128; IPPc; 1.
DR SUPFAM; SSF56219; DNase I-like; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000256970}.
FT DOMAIN 847..1040
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 21..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1039..1095
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1039..1057
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1077..1095
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1095 AA; 115487 MW; 2E7347124F44E19E CRC64;
MKQLQGLQNA LQKAANLVQG KQLVDTPQAH AVPSPGQQHQ RSGWPRPDDP VLEHLLRDFR
SAKLRRQFFS HDPKEYSETL DVKVLAGTYN VAGKRPPTGL KLHEWLHQWK DCWPQAAAAP
AAAGSAAGAG PDIVAIGFQE VVPLSAGNVI AGPSSAGADA WDYVLASTLN GDEWAGRNFG
RTFGSNMASQ AMYLNLERLG AQAYNVLSTQ AANVVGSMEK MWTGAGTEGA GAAGNGGAAS
AAQQQARLEQ ALASSEFGED EYVQVVSKQL VGVYLTVWAR KRTARHVRGV QTTSAATGFG
GYLGNKGAVA ARLRVHDAGL LLVASHLASG DAEGDELRRN ADVADILRRC TFSADQQPGQ
SLNGSTSSNG HWGSSSSILE HDNVVWLGDL NYRLTCSSDE ARRLLRADKL EALLSYDQLT
REMEAGHVFQ GWREGPISFS PTYKYHPSAV ASNANPTAAA AAAAAAAAAA TCCHQGWREG
PISFSPTYKY HLGCNVYSGE PLPPGVAMVR AVDSSNSLAD SASDTAEDSA TAGRDSPSVE
KQKKRTPAWC DRVLWLPGRQ LYQLAYGRGE IAVSDHRPVA AAFLLEAHRY NRDTVQQLAE
AARRNIDMSD NAARPRCLLH PNFIELQLLP FGVAASHTVS LSNEGATPAR FYFVAPPKPR
MSVDGQMCWD DNQPISPPWL AISPDQGEVA PGEAVSITLT AFVSGGGPAS AAAHIAANPP
PPPAPINTLD TILILRLEDG ADSFISCHGS LLPSCFGMDL DALLTLGDSP VLSETELQQG
QGKGRQLLQQ GLQRVAAAAA AGQEGEGEGD LLGLQQLELG DAAAAAAAGS GGAAGAGAGA
GDSKLVTGLE ERVPKEVQRL VSFLQVHLHT PGLFVHSHSA CCSSLQPRHA PHTKQQLQQL
LAATAPIRWA LDAGVDFPQH ATPHQAAAAL LLMLQQLPDS LMPPDVAAVL VHCVPPVPAA
MLSDAMSVTE WATLRHLLAL WRRALAPEVA ERNGLSAFSL AGVLAEHVFG DTAAAVPPEV
AANRVAFMMA LLDPQAAAPA TMQQQQQRQQ QLAAAPAGQP QQLPWGVPAP SAPVHQRGTS
AVAQSAAQQP SESLI
//
