ID A0A383WG30_TETOB Unreviewed; 1582 AA.
AC A0A383WG30;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=BQ4739_LOCUS16574 {ECO:0000313|EMBL:SZX76213.1};
OS Tetradesmus obliquus (Green alga) (Acutodesmus obliquus).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Sphaeropleales; Scenedesmaceae; Tetradesmus.
OX NCBI_TaxID=3088 {ECO:0000313|EMBL:SZX76213.1, ECO:0000313|Proteomes:UP000256970};
RN [1] {ECO:0000313|EMBL:SZX76213.1, ECO:0000313|Proteomes:UP000256970}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Cai Z.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; FNXT01001251; SZX76213.1; -; Genomic_DNA.
DR STRING; 3088.A0A383WG30; -.
DR Proteomes; UP000256970; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF69; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 2.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000256970}.
FT DOMAIN 193..816
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 817..1071
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1066..1258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1340..1360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 245..272
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 18..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..410
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..436
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1066..1083
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1084..1101
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1102..1120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1138
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1199..1222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1223..1242
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 214..221
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1582 AA; 172730 MW; 5834BEB11BA39461 CRC64;
MPPRKKKNEV PAGQRAITSI FGSASRATQS EASHAPSSST AAGAAVATPA TAAGAAEAAP
TAVAAGPAAA ASAGPRLALQ QGPLDSRHQH QDQQHNQTAS SNQPTLSIAA TQLAQRLQQT
VGLIAAGQVV AQQQQDNRYY SSRTARYAAG DDGQASQQQQ QQQQQQGLQD HQQQQQQQEA
LRRAYLQTSC FSRLNAQQRQ AAMGDQKKPL LIVAGAGTGK TSTLITRILF LLSQPGVLPQ
HILCITFTNK AAEELQTRLQ QAMQEARAIA AAAAAGAQQQ QADDGMGYSG VLACTFHSYC
YRLLRRHFRA CGFTQCPAVW LEKDARAAMR LAMRLSDADR CLHQMQLWLG VNAATNPGWP
GVQLAAAQQH PQLMQAWFAE QREAKQKAEE AAAKKRQKRL DAEAKKQLKA VQGKRKQGRQ
QGQALSRGQQ TLEAASFQRR AGKLQRQHDQ QDVSQSEGSM ALPEQDDQQQ QQQQQQQPEQ
SSMPPPPPVQ QLQQQHMQHA DWQQTQQQQQ QAHQQQHHQH NSQHQWQQQQ QWNQQQQQPP
GQWPAQQQQQ HQQQPHGHWP AQQQQQQQQP PGQWPAQQQQ QQQQQQQQQP PGQWPAQQQQ
QHQPAGQGEQ QQGQQQQQQQ GNQEQLAGMV LRELQHAGKV RLYELLLQQY GEEGLAEAAP
PSVAALRQKI AVKEVKKVHK AIDGFKSSGE VPDQGRNVGV YAHYQALLKA CNAVDFNDLL
GHVVTLLDSH EGILKQQQHL RPYLLVDEYQ DCNMQQVRIV NQLQQETAQV TVVGDDAQSI
YGFRGAAPGV FRLYREVYER FNAGLVCALE ANYRSTPQIL LVAQALLQGC DTHPKQLIPQ
VSAEGQAPVK LLLLDTEDHE AAVIAEEAKR LHEQQQVPYK DMAVLFRCFQ YRGSKAHTRL
QKALTREGVP FVLVRDTSLF ERKEVKDVMA YAQLALSPDD DPSFERVLNV PARRLGAKLL
QQLREEQEQL LAADRDSLLE QQLLQQQQQR QNNMLQQQQQ QQQHSLYRIA CRLLRNGDIA
ALHAGKLQAF LETLQALYAD VRGLTPADAL LAVLRGVPGL VEDIQLQQRK KRKSEREGAA
AAAAAEEEEQ EEEEEQEEEG RQEPGADAAE QADRSSHAIG RGRARGRGRG RGRGSGRQPG
RGRSKAGGES TAAAGSAASP GRAAAAAAAG GGFVSARQRL QQQQHIEDDD EEAGSVSGTV
DGSMATAGTA ATSAAAADSD ADSSSAEDSD GSSDEDDSSG PADFDAEAAS AAAALTEKPP
ELVTYALEAL YEEAEKFSAQ WAAENGVAAA AADMPPAGGS SAGGNSNLVT AASAPNNEAS
SSRAAAGSSA AAAAAAADGK RGASGSNATQ QDPPPAAAAA APSPVVASLY ELMARQVMQQ
WSSRQLLASG LMTDFLLEEL YAAAGKSSRP LQDFIAHVAL KPHTEQQPQH GKRGSKQQQA
ARADALSIST IHAAKGLEYG CVWVVRWVDG FLPAWPREDD TFKAKTPAQQ EEALRAFRME
EQRLAHVAVT RAKQRLYLTV PQYRVAPNPH RQQTSWQADG RDDNVLAPSD FLNCLTRLAE
VKLANDEPVL EAENLRSDRV FD
//
