ID A0A383YRY9_BALAS Unreviewed; 923 AA.
AC A0A383YRY9;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Receptor-type tyrosine-protein phosphatase N2 {ECO:0000313|RefSeq:XP_007165554.1};
GN Name=PTPRN2 {ECO:0000313|RefSeq:XP_007165554.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007165554.1};
RN [1] {ECO:0000313|RefSeq:XP_007165554.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007165554.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004212}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004212}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_007165554.1; XM_007165492.1.
DR AlphaFoldDB; A0A383YRY9; -.
DR STRING; 310752.A0A383YRY9; -.
DR KEGG; bacu:102999559; -.
DR CTD; 5799; -.
DR InParanoid; A0A383YRY9; -.
DR OrthoDB; 2911650at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0030141; C:secretory granule; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.30.70.2470; Protein-tyrosine phosphatase receptor IA-2 ectodomain; 1.
DR InterPro; IPR033522; IA-2/IA-2_beta.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR021613; Receptor_IA-2_dom.
DR InterPro; IPR038112; Receptor_IA-2_ectodomain_sf.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46106; IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C; 1.
DR PANTHER; PTHR46106:SF5; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2; 1.
DR Pfam; PF11548; Receptor_IA-2; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SMART; SM01305; RESP18; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000313|RefSeq:XP_007165554.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 523..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 653..913
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 832..904
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 80..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 581..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..354
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 923 AA; 101149 MW; 68F1F0C41FAE82AF CRC64;
MVLTEPCCLF EDGLCAPFET CVNDGVFGRC EEFTAVDMHH YEVSPGVLQH LTATLRALSR
TGLTWQDGYT QHVMARELAG LPQASPRRPE ASSPARSSKQ SVQDKRSLSL EGDVLAEALQ
RYLPYLEALS QAAGPDVLPG LKPDRPPAQG EDPPADSALT FVARTSALTY APASRADFPP
PAPPRDGDPA PRNLVRMPWR EPRVLSAPAA PQKWPSPPDP RDALGTDDGA RVQALLKDLR
KRPGSVEGLS ALDVAEAARA IASAMPGGPR GQAGRSGASR HRDGVPGNRV RDGGAGVYQE
VSRLGVKLED LLQGPGSPFL PGAPRLAGSF KTEIKKSEDP EASPSSEEDR FGVENIKSQT
YSKELLQRPP HPEPGPSRLG ASQLRAPVAP QEDQRPGAGA RRPPSQGLRL EVQPPQEEYG
YIVTENDPLS PETGTEVLED VALLLDMPAG VFSDIAVSGP AVTFRVRANV QNVTAADAAK
AAADNKDQLE RMSGLRVLQT GVGSKSKLKL LPHQAEREDS TKFIVLTLVS IVAIVAVLLA
SGVIYCLRHS SQYRLKEKLS GPGGDPDPDA TNAYQELCRQ RMAARPSERP ETARTSRVSS
VSSQFSDGPM PSPSARGSTS SWSEEPVQPN MDISTGHMVL AYMEDHLKNK NRLEKEWEAL
CAYQAEPNSS LVAQREENVP KNRCPAVLTY DHSRIRLKSE NSHRSSDYIN ASPIMDHDPR
KPAYIATQGP LPATVADFWQ MVWESGCVVI VMLTPLSENG VRQCYHYWPD EGSNLYHVYE
VHLVSEHIWC EDFLVRSFYL KNLQTNETRT VTQFHFLSWY DQGVPSSTRS LLDFRRKVNK
CYRGRSCPII VHCSDGAGRS GTYILIDMVL NKMAKGAKEI DIAATLEHLR DQRPRMVQTK
EQFEFALTAV AEEVNAILKA FPQ
//
