ID A0A383YT68_BALAS Unreviewed; 4858 AA.
AC A0A383YT68;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Probable E3 ubiquitin-protein ligase HERC1 isoform X5 {ECO:0000313|RefSeq:XP_007166043.1};
GN Name=HERC1 {ECO:0000313|RefSeq:XP_007166043.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007166043.1};
RN [1] {ECO:0000313|RefSeq:XP_007166043.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007166043.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
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DR RefSeq; XP_007166043.1; XM_007165981.2.
DR KEGG; bacu:103020812; -.
DR CTD; 8925; -.
DR OrthoDB; 5491782at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR CDD; cd12881; SPRY_HERC1; 1.
DR CDD; cd14401; UBA_HERC1; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035768; SPRY_HERC1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22872; BTK-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR22872:SF6; E3 UBIQUITIN-PROTEIN LIGASE HERC1-RELATED; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00415; RCC1; 10.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00449; SPRY; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS00626; RCC1_2; 4.
DR PROSITE; PS50012; RCC1_3; 14.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 372..421
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 422..476
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 477..529
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 530..579
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 581..632
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 633..683
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 684..736
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 1999..2190
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REPEAT 3421..3462
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 3619..3650
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 3740..3781
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 3994..4042
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4043..4097
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4098..4149
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4150..4201
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4203..4254
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4255..4306
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4307..4358
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 4498..4845
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 125..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1322..1341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1348..1379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1397..1432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2254..2285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2404..2488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2614..2672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2689..2749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2795..2873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3233..3252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1325..1341
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1348..1364
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2404..2433
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2434..2475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2619..2666
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2689..2740
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 4808
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 4858 AA; 531873 MW; C88360768D3C1986 CRC64;
MATMVPPVKL KWLEHLNSSW ITEDSESIAT REGVAVLYSK LVSNKEVVPL PQQVLCLKGP
QLPDFERESL SSDEQDHYLD ALLSSQLALA KMVCSDSPFA GALRKRLLVL QRVFYALSNK
YHDKGKVKQQ QHSPESSSGS ADVHSVSERP RSSTDALIEM GVRTGLSLLF ALLRQSWMMP
VSGPGLSLCN DVIHTAIEVV SSLPPLSLAN ESKIPPMGLD CLSQVTTFLK GVTIPNSGAD
TLGRRLASEL LLGLAAQRGS LRYLLEWIEM ALGASAVVNS MEKSKLLSSQ EGMISFDCFM
TILMQMRRSL SSSADRSQWR EPPRTSDGLC SLYEAALCLF EEVCRMASDY SRTCASPDSI
QTGDAPIVSE TCEVYVWGSN SSHQLVEGTQ EKILQPKLAP SFSDAQTIEA GQYCTFVISM
DGSVRACGKG SYGRLGLGDS NNQSTLKKLT FEPHRSIKKV SSSKGSDGHT LAFTTEGEVF
SWGDGDYGKL GHGNSSTQKY PKLIQGPLQG KVVVCVSAGY RHSAAVTEDG ELYTWGEGDF
GRLGHGDSNS RNIPTLVKDI SNVGEVSCGS SHTIALSKDG RTVWSFGGGD NGKLGHGDTN
RVYKPKVIEA LQGMFIRKVC AGSQSSLALT STGQVYAWGC GACLGCGSSE ATALRPKLIE
ELAATRVVDI SIGDSHCLAL SHDNEVYAWG NNSMGQCGQG NSTGPITKPK KVSGLDGIAI
QQISAGTSHS LAWTALPRDR QVVAWHRPYC VDLEESTFSH LRSFLERYCD KINSEIPPLP
FPSSREHHNF LKLCLKLLSN HLALALAGGV ATSILGRQAG PLRNLLFRLM DSTVPDEIQE
VVIETLSVGA TMLLPPLRER MELLHSLLPQ GPDRWESLSK GQRMQLDIIL TSLQDHTHVA
SLLGYSSPSD AADLSSVCTG YGNLSDQPYG TQSCHPDTHL AEILMKTLLR NLGFYTDQAF
GELEKNSDKF LLGTSSSENS QPAHLHELLC SLQKQLLAFC HINNISENSS SVALLHKHLQ
LLLPHATDIY SRSANLLKES PWNGSVGEKL RDVIYVSAAG SMLCQIVNSL LLLPVSVARP
LLSYLLDLLP PLDCLNRLLP AATLLEDQEL QWPLHGGPEL IDPAGVPLPQ PAQSWVWLVD
LERTIALLIG RCLGGMLQGS PVSPEEQDTA YWMKTPLFSD GVEMDTPQLD KCMSCLLEVA
LSGNEEQKPF DYKLRPEIAV YVDLALGCSK EPARSLWISM QDYAISKDWD SATLSNESLL
DTVSRFVLAA LLKHTNLLSQ ACGESRYQPG KSLSEVYRCV YKVRSRLLAC KNLELIQTRS
SSRDRWISEN QDSADVDPQE HSFTRTIDEE AEMEEQAERD REEGHPEPED EEEEREHEVM
TAGKIFQCFL SAREVARSRD RDRMNSGAGS GARADDPPPQ SQQERRVSTD LPEGQDVYTA
ACNSVIHRCA LLILGVSPVI DELQKRREEG QLQQPSTSAS EVGGLMTRSE SLTAESRLIH
ASPNYRLIKS RSESDLSQPE SDEEGYALSG RRNVDLDLAS SHRKRGPMHN QLEILSDSWA
RLKHNRDWLC NSSNSFESDF DLTKSLGVHT LIENVVSFVS GDVGNAPGFK EPEESMSTSP
QASIIAMEQQ QLRAELRLEA LHQILVLLSG MEEKGNISLT GSRSSSGFQS STLLTSVRLQ
FLAGCFGLGT DGHAGAKGES GRLHHYQDGI RAAKRNIQIE IQMAVHKIYQ QLSATLERAL
QANKHHIEAQ QRLLLVTVFA LSVHYQPVDV SLAISTGLLN VLSQLCGTDT MLGQPLQLLP
KTGVSQLSTA LKVASTRLLQ ILAITTGTYA DKLSPKVVQS LLDLLCSQLK NLLSQAGVLL
MASFGEGEED EEEKKIDSSG ETEKRDFRAA LRKQRAAELH LGDFLVFLRR VVSSKAIQSK
MASPKWTEVL LNIASQKCSS GIPLVGNLRT RLLALHVLEA VLPACESGVE DDQMAQVVER
LFSLLSDCMW ETPIAQAKYA IQIKEKEQEI KLQKQGELEE EDENLPIQEV SFDPEKAQCC
IVENGQVLTH GSGGKGYGLA STGVTSGCYQ WKFYIVKENR GNEGTCVGVS RWPVHDFNHR
TTSDMWLYRA YSGNLYHNGE QTLTLSSFTQ GDFITCVLDM EARTISFGKN GEEPKLAFED
VDAAELYPCI MFYSSNPGEK VKICDMQMRG TPRDLLPGDP ICSPVAAVLA EATIQLIRIL
HRTDRWTYCI NKKMMERLHK IKICIKDSGQ KLKKSRSVQS REENEMREEK ESKEEEKGKH
NRHGLADLSE PQLRTLCIEV WPVLAVIGGV DAGLRVGGRC VHKQTGRHAT LLGMVKEGST
SAKVQWDEAE ITISFPTFWS PSDTPLYNLE PCEPLPFDVA RFRGLTASVL LDLTYLTGIH
EDMGKQSTKR HEKKHRHESE EKGDVEQKIE SESALDTRTG LTSDDVKSQG TTSSKSENEI
ASFSLDSTVP GVESQHQITE GKRKNHEHIS KNHDIAQSEI RAVQLSYLYL GAMKSLSALL
GCSKYAELLL IPKVLAENGH NSDCASSPVV HEDVEMRAAL QFLMRHMVKR AVMRSPIKRA
LGLADLERAQ AVIYKLVVHG LLEDQFGGKI KQEIDQQAEE SDQAQQAQTP VTTSPSASST
TSFMSSSLED TTTATTPVTD TETVPASESP GVMPLSLLRQ MFSSYPTTTV LPTRRAQTPP
ISSLPTSPSD EVGRRQSLTS PDSQSARPAN RTALSDPSSR LSTSPPPPAI AVPLLEMGFS
LRQIAKAMEA TGARGEADAQ NITVLAMWMI EHPGHEDEEE PQSGSTADSR HGAAVVGSGG
KSNDPCYLQS PGDIPSADAA EMEEGFSESP DNLDHVENAA SGSGPPARGR SAVTRRHKFD
LAARTLLARA AGLYRSVQAH RNQSRREGIS LQQDPGALYD FNLDEELEID LDDEAMEAMF
GQDLTSDNDI LGMWIPEVLD WPTWHVCESE DREEVVVCEL CECSVVSFNQ HMKRNHPGCG
RSANRQGYRS NGSYVDGWFG GECGSGNPYY LLCGSCREKY LALKTKSKAT SSERYKGQAP
DLIGKQDSVY EEDWDMLDVD EEEKLTGEEE FELLAGPLGL NDRRIVPEPV QFPDSDPLGA
SVAMVTATNS MEETLMQIGC HGSVEKSSSG RITLGEQAAA LANPHDRVVA LRRVTAAAQV
LLARTMVMRA LSLLSVSGSS CSLAAGLESL GLTDIRTLVR LMCLAAAGRA GLSTSPSAMA
STSERSRGGH SKANKPISCL AYLSTAVGCL ASNTPSAAKL LVQLCTQNLI SAATGVNLTT
VDDPIQRKFL PSFLRGIAEE NKLVTSPNFV VTQALVALLA DKGAKLRPNY DKSEVEKKGP
LELANALAAC CLSSRLSSQH RQWAAQQLVR TLAAHDRDNQ TTPQTLADMG GDLRKCSFIK
LEAHQNRVMT CVWCNKKGLL ATSGSDGTIR VWNVTKKQYS LQQTCVFNRL EGDAEESLGS
PSDPSFSPVS WSISGKYLAG ALEKMVNIWQ VNGGKGLVDI QPHWVSALAW PEEGPSSAWS
GESPELLLVG RMDGSLGLIE VVDVSTMHRR ELEHCYRKDV SVTCIAWFSE DRPFAVGYFD
GKLLLGTKEP LEKGGIVLID AHKDTLTSMK WDPTGHILMT CAKEENVKLW GPIAGCWRCL
HSLCHPSIVN GIAWCSLPGK GSKLHLLMAS GCQSGLVCVW RIPQDTTQTS VTSSEGWWDQ
ESNCQDGYRK SVGAKCVYQL RGHITPVRTV AFSSDGLALV SGGLGGLMNI WSLRDGSVLQ
TVVIGSGAIQ TTVWIPDVGV AACSNRSKDV LVVNCTAEWA AANHVLATCR TALKQQGVLG
LNMAPCMRAF LERLPVMLQE QYAYEKPHVV CGDQLVHSPY MQCLASLAVG LHLDQLLCDP
PVPPHHQNCL PDPASWNPNE WAWLECFSTT IKAAEALTNG AQFPESFTVP DLEPVPEDEL
VLLMDNSKWI NGMDEQIMSW ATSRPEDWHL GGKCDVYLWG AGRHGQLAEA GRNVMVPAAA
PSFSQAQQVI CGQNCTFVIQ ANGTVLACGE GSYGRLGQGN SDDLHVLTVI SALQGFVVTQ
LVTSCGSDGH SMALTESGEV FSWGDGDYGK LGHGNSDRQR RPRQIEALQG EEVVQMSCGF
KHSAVVTSDG KLFTFGNGDY GRLGLGNTSN KKLPERVTVL EGYQIGQVAC GLNHTLAVSA
DGSMVWAFGD GDYGKLGLGN STAKSSPQKV DVLCGIGIKK VACGTQFSVA LTKDGHVYTF
GQDRLIGLPE GRARNHNRPQ QIPVLAGVVI EDVAVGAEHT LALASTGDVY AWGSNSEGQL
GLGHTNHVRE PTLVTVLQGK NVRQISAGRC HSAAWTAPPV PPRAPGVSVP LQLGLPDAVP
PQYGALREVS IHTARARLRL LYHFSDLMYS SWRLLNLSPN NQNSTSHYNA GTWGIVQGQL
RPLLAPRVYT LPMVRSIGKT MVQGKNYGPQ ITVKRISTRG RKCKPIFVQI ARQVVKLNAS
DLRLPSRAWK VKLVGEGADD AGGVFDDTIT EMCQELETGI VDLLIPSPNA TAEVGYNRDR
FLFNPSACLD EHLMQFKFLG ILMGVAIRTK KPLDLHLAPL VWKQLCCVPL TLEDLEEVDL
LYVQTLNSIL HIEDSGITEE SFHEMIPLDS FVGQSADGKM VPIIPGGNSI PLTFSNRKEY
VERAIEYRLH EMDRQVAAVR EGMSWIVPVP LLSLLTAKQL EQMVCGMPEI SVEVLKKVVR
YREVDEQHQL VQWFWHTLEE FSNEERVLFM RFVSGRSRLP ANTADISQRF QIMKVDRPYD
SLPTSQTCFF QLRLPPYSSQ LVMAERLRYA INNCRSIDMD NYMLSRNVDN AEGSDTDY
//
