ID A0A383YTX6_BALAS Unreviewed; 491 AA.
AC A0A383YTX6;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Protein Mdm4 {ECO:0000256|PIRNR:PIRNR006748};
GN Name=MDM4 {ECO:0000313|RefSeq:XP_007166231.1,
GN ECO:0000313|RefSeq:XP_007166232.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007166231.1};
RN [1] {ECO:0000313|RefSeq:XP_007166231.1, ECO:0000313|RefSeq:XP_007166232.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007166231.1,
RC ECO:0000313|RefSeq:XP_007166232.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- FUNCTION: Inhibits p53- and p73-mediated cell cycle arrest and
CC apoptosis by binding its transcriptional activation domain.
CC {ECO:0000256|PIRNR:PIRNR006748}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR006748}.
CC -!- SIMILARITY: Belongs to the MDM2/MDM4 family.
CC {ECO:0000256|ARBA:ARBA00005803, ECO:0000256|PIRNR:PIRNR006748}.
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DR RefSeq; XP_007166231.1; XM_007166169.1.
DR RefSeq; XP_007166232.1; XM_007166170.1.
DR AlphaFoldDB; A0A383YTX6; -.
DR STRING; 310752.A0A383YTX6; -.
DR GeneID; 103014402; -.
DR KEGG; bacu:103014402; -.
DR CTD; 4194; -.
DR InParanoid; A0A383YTX6; -.
DR OrthoDB; 2916169at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0065008; P:regulation of biological quality; IEA:UniProt.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR CDD; cd17673; MDM4; 1.
DR CDD; cd16784; mRING-HC-C2H2C4_MDM4; 1.
DR Gene3D; 1.10.245.10; SWIB/MDM2 domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR015458; MDM4.
DR InterPro; IPR016495; p53_neg-reg_MDM_2/4.
DR InterPro; IPR036885; SWIB_MDM2_dom_sf.
DR InterPro; IPR003121; SWIB_MDM2_domain.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12183; MITOCHONDRIAL UBIQUITIN LIGASE ACTIVATOR OF NFKB 1; 1.
DR PANTHER; PTHR12183:SF37; PROTEIN MDM4; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR Pfam; PF00641; zf-RanBP; 1.
DR PIRSF; PIRSF500699; MDM4; 1.
DR PIRSF; PIRSF006748; p53_MDM_2/4; 1.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 1.
DR SUPFAM; SSF47592; SWIB/MDM2 domain; 1.
DR PROSITE; PS51925; SWIB_MDM2; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS50199; ZF_RANBP2_2; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR006748}; Nucleus {ECO:0000256|PIRNR:PIRNR006748};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRNR:PIRNR006748};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00322}.
FT DOMAIN 25..108
FT /note="DM2"
FT /evidence="ECO:0000259|PROSITE:PS51925"
FT DOMAIN 300..329
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 438..479
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 491 AA; 55188 MW; 6AE7C8D98A390EC0 CRC64;
MTTFSTSAHC STSDSACRIS PEQTNQVRPK LPLLKILQAA GAQGEMFTVK EVMHYLGQYI
MVKQLYDQQE QHMVYCGGDL LGELLGRQSF SVKDPSPLYD MLRKNLVTLA TATTDAAQTL
ALAQDHSMDI PSQDQLKQSV EESSNSRKRT EEGNIPTLPT SQRKCRNSRE DEDLVANLTQ
DETSRLDLGF EEWDVAGLPW WFLGNLRNNY TPRSNGSTDL QTNQDIGTAI VSDTTDDLWF
LNESVSEQFG VGIKVEATDP EQTSEEVGKV RDKKVIEVGK NDDLEDSKSI SDDTDIEVTS
EDEWQCTECK KFNSPSKRYC FRCWALRKDW YSDCSKLTHS LSTSDITAIP EKQENEGIDV
PDCRRTISAP VVRPKDICVK EENSKLFGPC NSVEFLDLAH SSESQETISS MGEQSDNLFE
QRTDTETMED CQNLLKPCSL CEKRPRDGNI IHGRTGHLVT CFHCARRLKK AGASCPICKK
EIQLVIKVFI A
//
