ID A0A383YWK8_BALAS Unreviewed; 966 AA.
AC A0A383YWK8;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 08-NOV-2023, entry version 18.
DE SubName: Full=Son of sevenless homolog 1 isoform X2 {ECO:0000313|RefSeq:XP_007167191.1};
GN Name=SOS1 {ECO:0000313|RefSeq:XP_007167191.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007167191.1};
RN [1] {ECO:0000313|RefSeq:XP_007167191.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007167191.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
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DR RefSeq; XP_007167191.1; XM_007167129.2.
DR AlphaFoldDB; A0A383YWK8; -.
DR CTD; 6654; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd01261; PH_SOS; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF168; SON OF SEVENLESS HOMOLOG 1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681}.
FT DOMAIN 35..225
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 278..381
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 432..576
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 615..854
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 854..966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 926..959
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 966 AA; 111501 MW; B195A1D595E4DB47 CRC64;
MCADKVLMDM FHQDVEDIKI LSLTDEEPST SGEQTYYDLV KAFMAEIRQY IRELNLIIKV
FREPFVSNSK LFSANDVENI FSRIVDIHEL SVKLLGHIED TVEMTDEGSP HPLVGSCFED
LAEELAFDPY ESYARDILRP GFHDRFLSQL SKPGAALYLQ SIGEGFKEAV QYVLPRLLLA
PVYHCLHYFE LLKQLEEKSE DQEDKECLKQ AITALLNVQS GMEKICSKSL AKRRLSESAC
RFYSQQMKGK QLAIKKMNEI QKNIDGWEGK DIGQCCNEFI MEGTLTRVGA KHERHIFLFD
GLMICCKSNH GQPRLPGASN AEYRLKEKFF MRKVQINDKD DTNEYKHAFE IILKDENSVI
FSAKSAEEKN NWMAALISLQ YRSTLERMLD VTMLQEEKEE QMRLPSADVY RFAEPDSEEN
IIFEENVQPK AGIPIIKAGT VIKLIERLTY HMYADPNFVR TFLTTYRSFC KPQELLSLLI
ERFEIPEPEP TEADRIAIEN GDQPLSAELK RFRKEYIQPV QLRVLNVCRH WVEHHFYDFE
RDADLLQRME EFIGTVRGKA MKKWVESITK IIQRKKIARD NGPGHNITFQ SSPPTVEWHI
SRPGHIETFD LLTLHPIEIA RQLTLLESDL YRAVQPSELV GSVWTKEDKE INSPNLLKMI
RHTTNLTLWF EKCIVETENL EERVAVVSRI IEILQVFQEL NNFNGVLEVV SAMNSSPVYR
LDHTFEQIPS RQKKILEEAH ELSEDHYKKY LAKLRSINPP CVPFFGIYLT NILKTEEGNP
EVLKRHGKEL INFSKRRKVA EITGEIQQYQ NQPYCLRVES DIKRFFENLN PMGNSMEKEF
TDYLFNKSLE IEPRNPKPLP RFPKKYSYPL KSPGVRPSNP RPGTMRHPTP LQQEPRKISY
SRIPESETES TASAPNSPRT PLTPPPASGA SSTTDVCSVF DSDHSSPFHS SSDTVFIQVT
LPHGPS
//
