ID A0A383YWW6_BALAS Unreviewed; 409 AA.
AC A0A383YWW6;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=THUMP domain-containing protein 2 isoform X2 {ECO:0000313|RefSeq:XP_007167179.1};
GN Name=THUMPD2 {ECO:0000313|RefSeq:XP_007167179.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007167179.1};
RN [1] {ECO:0000313|RefSeq:XP_007167179.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007167179.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC {ECO:0000256|ARBA:ARBA00008361}.
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DR RefSeq; XP_007167179.1; XM_007167117.1.
DR AlphaFoldDB; A0A383YWW6; -.
DR GeneID; 103020157; -.
DR CTD; 80745; -.
DR OrthoDB; 5406466at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd11715; THUMP_AdoMetMT; 1.
DR Gene3D; 3.30.2130.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR004114; THUMP_dom.
DR PANTHER; PTHR14911; THUMP DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR14911:SF1; THUMP DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF02926; THUMP; 1.
DR Pfam; PF01170; UPF0020; 1.
DR SMART; SM00981; THUMP; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF143437; THUMP domain-like; 1.
DR PROSITE; PS51165; THUMP; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00529};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 53..172
FT /note="THUMP"
FT /evidence="ECO:0000259|PROSITE:PS51165"
FT REGION 326..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 409 AA; 45372 MW; E1F55C7FB0C0D24B CRC64;
MQRLTNDDPE SWLNAISIWK NLLELDAKKV KLSQKNANPL KRKVGENDII AKKLKTEQMQ
EIQENKECQL EKQIEEETLE QGNFTTKRDK SQEELQNDVA EAVGTHNQND LTFRVSCRCS
GAIARTFTAQ EVGRVIGIAL TKQFGWKADL RNPNLEIFIH LSDIYSVVGI PVFRVPLASR
AYIKTAGLRS TIAWAMASLA EIKAGAVVLD PMCGLGTILL EAAKEWPDVY YVGADVSDSQ
LLGACDNLKA AGLKDKIELL KVSVIELPLP SESVDIIISD IPFGKKFKLG KDIKHIIQEM
ERVLRVGGTI VLLLSEDHHR RLKGCEESSV PLNSKGSRTD KPGSTECLNP EEKAAISEPA
SSSLAASNQE RLDRMPPFGS LVPVERYRVS LGKTDALIYK YRKLHSPGQ
//
