ID A0A383Z1I0_BALAS Unreviewed; 450 AA.
AC A0A383Z1I0;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
GN Name=HYAL1 {ECO:0000313|RefSeq:XP_007168744.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007168744.1};
RN [1] {ECO:0000313|RefSeq:XP_007168744.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007168744.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-
CC glucosamine and D-glucuronate residues in hyaluronate.; EC=3.2.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00000251,
CC ECO:0000256|RuleBase:RU610713};
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC {ECO:0000256|ARBA:ARBA00008871, ECO:0000256|PIRNR:PIRNR038193,
CC ECO:0000256|RuleBase:RU610713}.
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DR RefSeq; XP_007168744.1; XM_007168682.2.
DR AlphaFoldDB; A0A383Z1I0; -.
DR GlyCosmos; A0A383Z1I0; 1 site, No reported glycans.
DR GeneID; 103006722; -.
DR CTD; 3373; -.
DR OrthoDB; 5344684at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR018155; Hyaluronidase.
DR PANTHER; PTHR11769; HYALURONIDASE; 1.
DR PANTHER; PTHR11769:SF23; HYALURONIDASE-1; 1.
DR Pfam; PF01630; Glyco_hydro_56; 1.
DR PIRSF; PIRSF038193; Hyaluronidase; 1.
DR PRINTS; PR00846; GLHYDRLASE56.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU610713};
KW Hydrolase {ECO:0000256|RuleBase:RU610713};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681}.
FT ACT_SITE 146
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-1"
FT CARBOHYD 365
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-2"
FT DISULFID 58..348
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT DISULFID 222..236
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT DISULFID 373..384
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT DISULFID 378..433
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT DISULFID 435..444
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
SQ SEQUENCE 450 AA; 50187 MW; C035EE9A8DE4B55D CRC64;
MRPFSPEVSL DLPCAMAAHL LPICTLFLNL LGMAKGSRDP VVPNRPFATI WNANTQWCLE
RHGVDVDISV FDVAVNPGQT FHGPDMTIFY SSQLGTYPYY TSAGEPVFGG LPQNASLAVH
LVRTFQDILA AMPASNFSGL AVIDWEAWRP RWAFNWDTKD IYRQRSRALV QGQHPDWPAP
WVEAAAQDQF EGAARAWMAG TLRLGHALRP RGLWGFYGFP DCYNYDFKNP NYTGQCPPGI
RAQNDQLGWL WGQSRALYPS IYLPAALEGT KKAQMFVQHR VGEAFRLAVG AGYPDLPVLP
YVQIFYDMTN RFLPLEELEH SLGESAAQGA AGVVLWVSWE NTRTKESCQA IKEYVDTTLG
PFILNVTSGA LLCSQVLCSG HGRCARRPSH PEARLILSPT SFSIESTPGG GPLTLRGALS
LKDQLRMAVE FKCRCYRGWT GTWCEQWGMW
//
