ID A0A383Z4H1_BALAS Unreviewed; 1770 AA.
AC A0A383Z4H1;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Kinesin-like protein KIF1B isoform X6 {ECO:0000313|RefSeq:XP_007170075.1};
GN Name=KIF1B {ECO:0000313|RefSeq:XP_007170075.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007170075.1};
RN [1] {ECO:0000313|RefSeq:XP_007170075.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007170075.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR RefSeq; XP_007170075.1; XM_007170013.1.
DR CTD; 23095; -.
DR OrthoDB; 126886at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd22727; FHA_KIF1B; 1.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR CDD; cd01233; PH_KIFIA_KIFIB; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR049780; PH_KIFIA_KIFIB.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF2; KINESIN-LIKE PROTEIN KIF1A ISOFORM X1; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 5..348
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 510..566
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 1655..1753
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 894..913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1505..1525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 629..685
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1505..1524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 97..104
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1770 AA; 199022 MW; CB87DD2883E68720 CRC64;
MSGASVKVAV RVRPFNSRET SKESKCIIQM QGNSTSIINP KNPKEAPKSF SFDYSYWSHT
SPEDPCFASQ NRVYNDIGKE MLLHAFEGYN VCIFAYGQTG AGKSYTMMGK QEESQAGIIP
QLCEELFEKI NDNCNEEMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED
LSKLAVTSYT DIADLMDAGN KARTVAATNM NETSSRSHAV FTIVFTQKKH DTETNLSTEK
VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEVSK KKKKTDFIPY
RDSVLTWLLR ENLGGNSRTA MVAALSPADI NYDETLSTLR YADRAKQIKC NAVINEDPNA
KLVRELKEEV TRLKDLLRAQ GLGDIIDTSM GSLTSSPSSC SLNSQVGLTS VTSIQERIMS
TPGGEEAIER LKESEKIIAE LNETWEEKLR KTEAIRMERE ALLAEMGVAI REDGGTLGVF
SPKKTPHLVN LNEDPLMSEC LLYYIKDGIT RVGQADAERR QDIVLSGAHI KEEHCIFRSE
RNNGGDVIVT LEPCERSETY VNGKRVAQPV QLRSGNRIIM GKNHVFRFNH PEQARAEREK
TPSAETPSEP VDWTFAQREL LEKQGIDMKQ EMEKRLQEME ILYKKEKEEA DLLLEQQRLD
YESKLQALQK QVETRSLAAE TTEEEEEEEE VPWTQHEFEL AQWAFRKWKS HQFTSLRDLL
WGNAVYLKEA NAISVELKKK VQFQFVLLTD TLYSPLPPEL LPTEMEKTQE DRPFPRTVVA
VEVQDLKNGA THYWSLAKLK QRLDLMREMY DRAGEMASSA QDESETTMTG SDPFYDRFHW
FKLVGSAPIF HGCVNERLAD RTPSPTFSTA DSDITELADE QQDEMEDFDD EAFVDDTGSD
AGTEEGSDLF SDGHDPFYDR SPWFILVGRA FVYLSNLLYP VPLIHRVAVV SEKGEVRGFL
RVAVQAIAAD EEAPDYGSGI RQSGTAKISF DNEYFNQSDF SSVAMTRSGL SLEELRIVEG
QGQSSEVITP PEEISRMNDL DLKSSTLLDG KMVMEGFSEE IGNHLKLGSA FTFRVTVLQA
SGILPEYADI FCQFNFLHRH DEAFSTEPLK NHGRGSPLGF YHVQNIAVEV TESFVDYIKT
KPIVFEVFGH YQQHPLHLQG QELNSPPQPS RRFFPPPMPL SKPVPATKLN TMSKTSLGQS
MSKYDLLVWF EISELEPTGE YIPAVVDHTA GLPCQGTFLL HQGIQRRITV TIIHEKGSEL
HWKDVRELVV GRIRNKAEVD EAAVDAILSL NIISAKYLKS SHNSSRTFYR FEAVWDSSLH
NSLLLNRVTP YGEKIYMTLS AYLELDHCIQ PAVVTKDVCM VFYSRDAKIS PPRSLRSLFG
SGYSKSPDSN RVTGIYELSL CKMADTGSPG MQRRRRKILD TSVAYVRGEE NLAGWRPRGD
SLILEHQWDL EKLELLHEVE KTRHFLLLRE RLGDSIPTSL SDSLSPSLSS GTLSTSTSIS
SQISTTTFES AITPSESSGY DSTDIESLVD REKELATKCL QLLTHTFNRE FSQVHGSISD
CKLSDISPVG RDPSVSSFSS ATLTPSSTCP SLIDARSNSL DQKTPEANSR ASSPCPEFEQ
FQIVPALETP YLARAGKNEF LNLVPDIEEI RPGSVVSKKG YLHFKEPLSS NWAKHFVVVR
RPYVFIYNSD KDPVERGIIN LSTAQVEYSE DQQAMVKTPN TFAVCTKHRG VLLQALNDKD
MNDWLYAFNP LLAGTIRSKL SRRCPSQPKF
//
