ID   A0A383Z5M8_BALAS        Unreviewed;       612 AA.
AC   A0A383Z5M8;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Peroxisomal carnitine O-octanoyltransferase isoform X4 {ECO:0000313|RefSeq:XP_007170357.1};
GN   Name=CROT {ECO:0000313|RefSeq:XP_007170357.1};
OS   Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS   (Balaenoptera davidsoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC   Balaenopteridae; Balaenoptera.
OX   NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007170357.1};
RN   [1] {ECO:0000313|RefSeq:XP_007170357.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_007170357.1};
RG   RefSeq;
RL   Submitted (JAN-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8-
CC         dimethylnonanoyl-(R)-carnitine; Xref=Rhea:RHEA:44860,
CC         ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:77061,
CC         ChEBI:CHEBI:84654; Evidence={ECO:0000256|ARBA:ARBA00024283};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
CC   -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR   RefSeq; XP_007170357.1; XM_007170295.2.
DR   AlphaFoldDB; A0A383Z5M8; -.
DR   GeneID; 103003725; -.
DR   CTD; 54677; -.
DR   OrthoDB; 1429709at2759; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000261681; Unplaced.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 1.10.275.20; Choline/Carnitine o-acyltransferase; 1.
DR   Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR   InterPro; IPR000542; Carn_acyl_trans.
DR   InterPro; IPR042572; Carn_acyl_trans_N.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR039551; Cho/carn_acyl_trans.
DR   InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR   PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR   PANTHER; PTHR22589:SF67; PEROXISOMAL CARNITINE O-OCTANOYLTRANSFERASE; 1.
DR   Pfam; PF00755; Carn_acyltransf; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   PROSITE; PS00439; ACYLTRANSF_C_1; 1.
DR   PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|RuleBase:RU003801};
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          23..594
FT                   /note="Choline/carnitine acyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00755"
FT   ACT_SITE        327
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ   SEQUENCE   612 AA;  70239 MW;  2191BE10073DBAA3 CRC64;
     MENQLAKSTE ERTFQYQDSL PSLPVPSLEE SLKKYLESVK PFANEEEYKK TEAIVQKFQN
     GIGEKLQQKL LERAKEKRNW LEDWWLNVAY LDVRIPSQLH VNFGGPASHI EHYWPPKEGT
     QLERGSISLW HILNYWQLLR KEKLPVHKVG NTPLDMNQFR MLFATCKVPG ITRDSLINYF
     RTESEGHCPS HIAVMCRGRV FVFDVMHEGC LMTPPEILRQ LTYIQKKCRR EPDGPGVAAL
     TSEERTRWAK AREYLISLNP ENLTMLEKIQ SSLLVFCLDD GSPRVTPEDY SQVATKVLTG
     DPTVRWGDKS YNLISFSNGV FGCNCDHAPY DAMVIVSISY YVDQKIFESE GKWTGSDKVQ
     DIPLPEELVF TVDEKVLNDI NQAKAQYFKQ ASDLQLLVYA FTSFGKKLTK KKKLHPDTFV
     QLALQLAYYR LHGRPGCCYE TAMTRYFFHG RTETVRSCTV EAVRWCQSMQ GPSASLFEQQ
     HRMLEAFAKH NKMMKDCSTG KGFDRHLLGL SLIAKEECLP VPELFTDPLF SRSGGGGNFV
     LSTSLIGYLR VQGVVVPMVH NGYGFFYHIR DDRFIVACTA WKSCPETDAE KLVQQTFRAF
     NDMMQLMDIA HL
//