ID A0A383ZFW1_BALAS Unreviewed; 4643 AA.
AC A0A383ZFW1;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Protocadherin Fat 1 isoform X1 {ECO:0000313|RefSeq:XP_007174043.1};
GN Name=FAT1 {ECO:0000313|RefSeq:XP_007174043.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007174043.1};
RN [1] {ECO:0000313|RefSeq:XP_007174043.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007174043.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_007174043.1; XM_007173981.1.
DR STRING; 310752.A0A383ZFW1; -.
DR KEGG; bacu:103000804; -.
DR CTD; 2195; -.
DR InParanoid; A0A383ZFW1; -.
DR OrthoDB; 2961370at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 33.
DR CDD; cd00054; EGF_CA; 4.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 34.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF448; FAT ATYPICAL CADHERIN 2; 1.
DR Pfam; PF00028; Cadherin; 29.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 33.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 33.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00232; CADHERIN_1; 13.
DR PROSITE; PS50268; CADHERIN_2; 33.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..4643
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016772730"
FT TRANSMEM 4205..4225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..149
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 150..257
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 368..463
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 464..569
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 577..671
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 718..822
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 823..927
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 928..1034
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1043..1139
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1140..1245
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1246..1357
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1359..1479
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1480..1585
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1586..1690
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1691..1788
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1789..1902
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1903..2002
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2003..2104
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2105..2205
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2206..2306
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2307..2413
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2414..2515
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2516..2619
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2620..2726
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2727..2832
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2833..2941
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2942..3046
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3047..3148
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3149..3253
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3254..3358
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3359..3463
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3464..3568
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3584..3670
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3813..3850
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3852..4032
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 4036..4073
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4075..4111
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4112..4148
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4150..4186
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 4276..4298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4326..4350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4488..4534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4547..4577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4617..4643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4278..4296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4488..4507
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 3822..3839
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4063..4072
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4101..4110
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4138..4147
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4176..4185
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4643 AA; 512758 MW; 74DD79143F1AEDEF CRC64;
MGRHLASLLL LLLLLQHFGD SDGSQALEQT PVQFTHFQYN VTVHENSAAK TYVGHPVKMG
IYITNPLWEL RYKIVSGDNE NLFKAEEYVL GDFCFLRIRT KGGNTAILNR EVKDHYTLIV
RAVEKNTNAE ARTKVRVQVL DTNDLRPLFS PTSYSVSLPE NTALRTSIAR VSATDADIGT
NGEFYYSFKD RTDMFAIHPT SGTVVLTGRL DYTETKFYEM EILAVDRGMK LYGSSGVSSM
AKLAVHVEQA NECAPVVTAV TSSPSELEQD PTYAIITVDD CDRGANGEVA SLSIVAGDLL
QQFRTVRTSP GSKEYKLKAV GDVDWDSHPF GYNLTLQAKD KGSPPQFSSV KVIQVTSPQF
KAGPVKFEKE VYRAEISEFA PPHTPVVMVK ATPSYSHLKY VFKTTPGKAK FSLNHNTGLI
SILEPIKRQQ ASHFELEVTT SDRKASTKVL VKVLSANSHP PEFTQTAYRA SFDENVPIGT
TVMSVSAVDL DEGENGYVTY SIANVNHVPF VINHFTGAVS TSEDLDYELM PRVYTLRIRA
SDWGLPYRRE VEVLATITLN NLNDNTPLFE KINCEGTIPR DLGVGEQITT VSAIDADELQ
LVRYQTEAGN ELDLFSLNPS SGVLSLKQSL MNGLGAKVSF HSLRITATDG ENFAAPSYIN
ITVAAPRKPV NLRCEETGVA RVLAEKLLQA NKLHSPGEAE DVFFDSHSVN AHTPQFRSTL
PAGIEVKENH PVGSSILFMN ATDLDTGFNG KLVYAISGGN EDSCFIIDME TGMLKILSPL
DRETTDRYTL NLTVSDLGLP QKAAWRLLEI RVLDANDNPP EFLQESYFVE VSEDKEINSE
IIQVEATDKD LGPNGHVTYS ILTDTDKFSI DSTTGVVKIV NPLDREEQHV HYVKIEARDQ
AREEPQLLST VLLKVSLEDV NDNPPKFIPP NYRVKVREDL PEGTIIMWLE AYDPDLSQSS
QVRYSLMDHG EGNFDVDKLS GAVRIIQQLD FEKKQVYNLT VRAKDKGKPI SLSSTCYIEV
EVIDVNENLH PPVFPSFVEK GVVKENVPVG SSVMKVSAHD EDTGRDGEIH YSIRDGSGVG
VFKIDEETGV IETSGQLDRE STSHYWLTVY ASDQGVVPLS SFVEVYIEVE DVNDNAPQTS
EPVYYPEIME NSPKDVSVVQ IEAFDPDSSS DDRLTYKITS GNPQGFFSIN PKTGLITTTS
RKLDREQQDE HILEVTVTDN GSPPRSTIAR VIVKILDEND NKPQFLQKFY KIRLPEREKP
ERERNTKREP LYRVIATDKD EGPNAEISYS IEEGNEHGKF FIEPKTGVVL SKKFSGAGEY
DILSIKAVDN GRPQKSSTTR LHIEWISKPK PSLEPISFEE SFFTFTVMES DPVAHMIGVI
SVEPPGIPLW FDIIGDTFAR EVFYIFQMTC DLNCTAEGGN YDSHFDVDKG TGTIIIARPL
DAEQKSNYNL TVEATDGTIT ILTQVFIKVI DTNDHRPQFS TSKYEVVIPE DTVPETEILQ
ISAVDKDEKN KLIYTLQSSI DPLSLKKFRL DPATGSLCTA EKLDHEAIQQ HVLTVMVRDQ
DVPVKRNFAR IVVNVSDTND HAPWFTSSSY KGRVYESAAV GSVVLQVTAL DKDKGKNAEV
LYSIESGNIG NSFTIDPILG SIKTAKELDR SNQVEYDLVV KAIDKGNPPM SEITSVCIFV
TIADNASPKF TSKEYSVEIS ETISIGSFVG MVTAHSQSSV VYEIKDGNIA NAFDINPHSG
SIITQKALDF ETLPIYTLTI QGTNMAGLST NTTVLVHLQD ENDNLPVFTQ AEYTGLISES
ASIHSVVLTD RNVPLVIRAT DADKESNALL VYHIVEPAIH KYFTVDSSTG AIHTVLSLDY
EQTSTFHFTV QVHDMGTPCL FAEYAANVTI HVIDINDCPP VFSTSLYEAS LLLPTYKGVR
VITVNATDAD SSAFSQLMYS ITEGNIGEKF LMDHKTGTIT VQNTTQLRSR YELTIRASDG
RFASLTSVKI NVKESKESQL KFTQDFYSAV VKENSTEARR LAVITAIGNP INEPLFYHIL
NPDRRFKISR TSGVLSTTGI PFDREQQETF DVVVEVTQEH KPSAVAHVIV KVIVEDQNDN
APVFVNLPYY AIVKVDTAVG HVIRYVTAID RDGGRNGEVH YYLKEHHEHF QIGASGEISL
KKQFEPDTLN KEYLVTVVAK DGGNPAFSAE VIVPITVMNK AMPVFEKPFY SAEIPENVQM
HSPVVHVQAN SPEGLKVFYS ITDGDPFSQF TINFNTGVIN VIAPLDFESH PAYKLSIRAT
DSLTGAHAEV FVDVIVDDIN DSPPVFAQQS YATTLSEASV IGTSVVQVRA TDSDSEPNRG
ISYHMFGNHS KSHDHFHIDS STGLISLVRT LDYEQFQQHK IFVRAVDGGM PPLSSDVLVT
VDVTDLNDHP PLFDQQIYEA RISEHAAHGH FVTCVKAYDA DSSDIDKLEY SILSGNDHKN
FVIDSRTGII TLSNLRRHAL KPSYTLQVSV SDGVFRSSAQ VHVSVIGGNL HSPIFLQNEY
EVELAENAPL HTLVTEVKAT DRDSGIYGHV TYHIVNDFAK DRFYTNERGQ IFTLEKLDRE
TPAEKVIPVR FMAKDTGGKV AFCTINVILT DDNDNAPQFR ATKFEVNIGS NAPKGTSVIK
VLASDADEGS NADVTYAIEA DSESVKENLE INRLSGIITT KESLIGLENE VFTFFVRAVD
NGSPPKESVV PVYVKVLPPE MRLPRFSEPF YTYTVSEDVP IGTEIDLIRA EHSETVLYSL
VKGNTPESNR DEFFVIDRQS GRLKLEKGLD HETTKWYQFS VLARCTHDDY EVVASVDVSI
QVKDANDNSP VLESSPYEAF TVENLPGGSR VIQIRASDLD SGTNGQVMYS LDQSQSVEVI
ESFTINMETG WITTLKELDH EKRDSYQIKV VASDHGEKVQ LSSTAIVDVT VTDVNDSPPR
FTAEIYKGTV SEDDPPGGVI AILSTTDADS EEINRQVTYY ITGGDPLGQF AIENIQNEWK
VYVKKPLDRE KRDNYLLTIT ATDGTFSSKA IVEVKVLDAN DNSPICEKTL YSDTIPEDAF
PGKLIMQVSA TDADIRSNAE ITYTLFGPGA EKFKLNPDTG ELKTLAPLDR EDQATYNLLV
KATDGGGRFC QADIVLTLED VNDNAPEFSA DPYTITVFEN TEPGTLLTRV QATDVDAGLN
RKVSYSLINS ADGQFSINEL SGIIQLEKPL DRELQAVYTL TLKAVDHGLP RRLTATGTVV
VSVLDINDNP PVFEYREYGS TVSEDVLIGT EVLQVYAASR DIEANAEITY SIISGNEHGK
FSIDSKTGAI FIIEHLDYES SHEYYLTVEA TDGGTPSLSD VATVNINVTD INDNTPVFSQ
DTYTAVISED AVLEQSVITV MADDADGPSN SHIHYSIIDG NQGSPFTIDP ARGEVKVTKL
LDRETISGYT LTVQASDNGS PPRVTTTTVN IDVSDVNDNA PVFSRGNYSL IIQENKPVGF
SVLQLAVTDR DSSHNGPPFF FSIVSGNKEG AFEVNQQGAL LTAAAINRKV KDHYLLHIKV
ADNGKPQLSS LTYIDIRVIE ESIYPPAILP LEIFITAFGE EYSGGVIGKI HATDQDVYDT
LTYSLDPQMG SLFSVSSTGG KLIAHKKLDV GQYLLNVSVT DGKFTTTADV TVHIRQVTQE
MLNQTMAVRF ANLTPEEFVG DYWRNFQRAL RNILGVRRND IQIVSLQPSE PHPHLDILLF
VEKSGSAQVS TKQLLHKINS SVTDIEEIIG VRILDVFRKL CAGLDCPWRF CDEKVSVDES
VMSTHSTARL SFVTPRHRRT AVCLCTGGKC PPVHYGCEDS PCPEGSECVT DPREETYTCV
CPGGKFGQCP GSSSVTFTGN SFVKYRLVEN ENKLEMKLTM RLRTYSPHAV VMYARGTDYS
ILEIHNGRLQ YKFDCGSGPG IVSVQSIQVN DGLWHAVSLE VNGNYARLVL DQVHTASGTA
PGTLKTLNLD SHVFFGGHIR QQGSRHGRSP QIGSGFRGCM DSIYLNGQEL PLNNKPRSYA
HVEESVDVSP GCLLTATEDC SSSPCQNGGA CHPSPTGGYY CKCSPLYIGT YCEVGVNPCS
STPCLYGGTC IVDNGDFLCQ CRGLYTGQRC QLSPYCKDEP CKNGGTCFDS LDGAVCQCDS
GFRGERCQSD IDECAGNPCR NGALCENTHG SYHCNCSREY RGRHCEDVTP NQYVSTPWDI
GLAEGIGIVV FIAGIFLLVL LFVFCRKMIS RKKKHQPKPE DKHLGPSAAF LQRPYFDSKL
NKNMYSDVPP QVPVRPISYT PSIPSDSRNN LDRNSFEGSA IPEHPEFSTF NPESVHGHRK
AVAVCSVAPN LPPPPPSNSP SDSDSIQKPN WDFDYDTKVV DLDPCLSKKP LEEKPSNAYS
ARESLCEVQS LSSFQSESCD DNASIVTVIH FVNAVVDTVT KEESFAAPDL SKSRGYHWDT
SDWMPSVPLP DIQEFPNYEV IDEQTPLYSA DPNAIDTDYY PGGYDIESDF PPPPEDFPVP
DELPPLPPEF SDQFESIHPP RDMPAAGSLG SSSRSRQRFN LNQYLPNFYP ADMSEPQKAG
PGENSARREP YAPYPPGYQR SFDASAVENM PVSVYASTAS CSDVSACCEA ESEVMMSDYE
SGDDGHFEEV TIPPLDSQQH TEV
//
