ID A0A383ZI52_BALAS Unreviewed; 486 AA.
AC A0A383ZI52;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Fatty acid desaturase 3 {ECO:0000313|RefSeq:XP_007174539.1};
GN Name=FADS3 {ECO:0000313|RefSeq:XP_007174539.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007174539.1};
RN [1] {ECO:0000313|RefSeq:XP_007174539.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007174539.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism; polyunsaturated fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005105}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}.
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DR RefSeq; XP_007174539.1; XM_007174477.1.
DR AlphaFoldDB; A0A383ZI52; -.
DR STRING; 310752.A0A383ZI52; -.
DR KEGG; bacu:102999979; -.
DR CTD; 3995; -.
DR InParanoid; A0A383ZI52; -.
DR OrthoDB; 294339at2759; -.
DR UniPathway; UPA00658; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0006636; P:unsaturated fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd03506; Delta6-FADS-like; 1.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR005804; FA_desaturase_dom.
DR InterPro; IPR012171; Fatty_acid_desaturase.
DR PANTHER; PTHR19353; FATTY ACID DESATURASE 2; 1.
DR PANTHER; PTHR19353:SF11; FATTY ACID DESATURASE 3; 1.
DR Pfam; PF00173; Cyt-b5; 1.
DR Pfam; PF00487; FA_desaturase; 1.
DR PIRSF; PIRSF015921; FA_sphinglp_des; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
PE 4: Predicted;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 175..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 91..138
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|Pfam:PF00173"
FT DOMAIN 199..457
FT /note="Fatty acid desaturase"
FT /evidence="ECO:0000259|Pfam:PF00487"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 486 AA; 55588 MW; 73665C693EDD3857 CRC64;
MAQAWRGPLS WSQHLPQERQ TDGVLEPALS QKLSRGTNGQ AMEAALSRHQ TSIPGRDLRR
CLIGEISRVS RHPPLSQALG TSTPLWPSFA SFPERHPGGS RLIGHHGAED ATDAFHAFHQ
DLNFVRKFLQ PLLIGELAPE EPSQDGPQNA QLIEDFRALR QAVEDMKLFE AKPTFFAFLL
GHILAMEVLA WLIIYLLGPG WVPSTLAALI LAVSQAQSWC LQHDLGHTSI FRKSRWNHVA
QQFVMGQLKG FSAHWWNFRH FQHHAKPNIF HKDPDVTVAP VFLLGESSVE YGKKKRRYLP
YNHQHLYFFL IGPPLLTLVN FEVENLAYML VCMQWTDLLW AASFYARFLL SYLPFYGVPG
ALFLFVAVRV LESHWFVWIT QMNHIPKEIG HEKHRDWASS QLAATCNVEP SLFLDWFSGH
LNFQIEHHLF PTMPRHNYRR VAPLVKALCA KHGLSYEVKP FLTALVDIIG SLKKSGNMWL
EAYLHQ
//
