ID   A0A383ZQE9_BALAS        Unreviewed;       877 AA.
AC   A0A383ZQE9;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A4 {ECO:0000313|RefSeq:XP_007177144.1};
OS   Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS   (Balaenoptera davidsoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC   Balaenopteridae; Balaenoptera.
OX   NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007177144.1};
RN   [1] {ECO:0000313|RefSeq:XP_007177144.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_007177144.1};
RG   RefSeq;
RL   Submitted (JAN-2023) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   RefSeq; XP_007177144.1; XM_007177082.1.
DR   AlphaFoldDB; A0A383ZQE9; -.
DR   GeneID; 103019646; -.
DR   CTD; 50617; -.
DR   OrthoDB; 1967517at2759; -.
DR   Proteomes; UP000261681; Unplaced.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF26; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 4; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        435..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        484..503
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        582..603
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        609..633
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        676..698
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        809..833
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   REGION          714..745
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          95..157
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   877 AA;  100614 MW;  74B88D85CE316BD8 CRC64;
     MTPGHEDLWE LLFHPLTGRH SAPSWGEEQN GDQGWVKMAS VFRSEEMCLS QLFLQVEAAY
     CCVAELGELG LVQFKDLNVN ESRFQRKFVN EVRRCESLER ILRFLEDQMQ NEIEIQVPEK
     SPSTPLPREM ITLETALEKL EGELQEANQN YQALKKSFLE LTEFKHLLKK TQDFFETETN
     LADDFFMEDT SGLLELRPTP AYMSGKLGFT AGVVNRERMA SFERLLWRIC RGNIYLKFSE
     MDTVLEDPVT REGIKKNIFI IFYQGEQLRQ KIKKICDGFR ATIYPCPEPA SERREMLDGV
     NMRLEDLITV ITQTESHRQR LLQEAAANWH SWVIKVHKMK AIYHVLNMCN IDVTQQCIIA
     EIWFPVADTV RIRRALEQGV ELSGSAMVPI MTAVQSKRAP PTFNRTNKFT AGFQNIVDAY
     GVGSYREMNP APYTIITFPF LFAVMFGDCG HGIVMLLAAL WMVLNERRLL SQKTTNEIWN
     TFFHGRYLIL LMGIFSIYTG LIYNDCFSKS FNIFGSSWSV QPMFRNGTWN TQVMETNPHL
     QLDPAVPGVY SGNPYPFGID PIWNLASNKL TFLNSYKMKM SVILGIVQMV FGVILSLFNH
     IFFRNTLNII LQFIPEMIFI LCLFGYLVFM IIFKWCSFDV SVSRQAPSIL IHFINMFLFN
     YNDPSNAPLY KHQQEVQSFF VIMALISVPW MLLIKPFILR ASHQKSQLQA SRIQEDATED
     IEGDNSNPSV RPGHRASAGA HGAQDDHDEE FNFGDIFVHQ AIHTIEYCLG CISNTASYLR
     LWALSLAHAQ LSEVLWTMVM NIGLRVQGWG GLIGVFIIFA IFAVLTVAIL LIMEGLSAFL
     HALRLHWVEF QNKFYVGAGY KFSPFSFKQI LDGTAEQ
//