ID A0A383ZWT4_BALAS Unreviewed; 1124 AA.
AC A0A383ZWT4;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Integrin alpha-7 isoform X1 {ECO:0000313|RefSeq:XP_007179588.1};
GN Name=ITGA7 {ECO:0000313|RefSeq:XP_007179588.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007179588.1};
RN [1] {ECO:0000313|RefSeq:XP_007179588.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007179588.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU003762}.
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DR RefSeq; XP_007179588.1; XM_007179526.2.
DR AlphaFoldDB; A0A383ZWT4; -.
DR KEGG; bacu:103006781; -.
DR CTD; 3679; -.
DR OrthoDB; 3816176at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF90; INTEGRIN ALPHA-7; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT TRANSMEM 1042..1064
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 35..103
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 310..371
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 372..427
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 431..490
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 475..639
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 641..805
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 811..1029
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 910..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..926
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1124 AA; 121871 MW; 318F2EC8A7DAE93D CRC64;
MAGTPGRDPW GAPGICYLLG SLLAGLLFPG AVAFNLDVMG ALRKEGEPGS LFGFSVALHR
QLQPGPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE TDCYRVDIDR GADVQKESKE
NQWLGVSVRS QGPGGKIVTC AHRYEARQRV DQILETRDVI GRCFVLSQDL AIRDELDGGE
WKFCEGRPQG HEQFGFCQQG TAAAFSPDSH YLLFGAPGTY NWKGTARVEL CVQGSADLAH
LDDGPYEAGG EKEQDPRLIP VPANSYFGFS IDSGKSLVRA EELSFVAGAP RANHKGAVVI
LRKDSASRLV PEVMLSGERL TSGFGYSLAV ADLNNDGWTD LVVGAPYYFE RQEELGGAVY
VYMNQGGHWA GVSPLRLCGS PDSMFGISLA VLGDLNQDGF PDLAVGAPFD GDGKVFIYHG
SSLGVVVKPS QVLEGEAVGI KSFGYSLSGG LDVDGNRYPD LLVGSLADTA VLFRARPVLH
VSHEVSILPR NIDLEQPNCA SGHSVCMDLR VCFSYIASPS SYSPVVALDY TLDGDTDRRL
RGQVPRVTFL SRGPDDPKHQ ASGTVWLKHQ HDRVCGDTML QLQENVKDKL RAIVVTLSYS
LQTPRLRRQA PGQGLPPVAP ILNAHQPSTQ RTEIHFLKQG CGEDKVCQSN LQLVHARFCA
RVSDTEFQPL PMDADGTTAL FALSGQPVIG LELKVTNLPS DPAQPQADGD DAHEAQLLVT
LPASLHYSGV RALDPAEKPL CLSNENASHV ECELGNPMKR GAQVTFYLIL STSGITIETT
ELEVELLLAT ISEQELQPVS ARARVFIELP LSITGVAIPQ QLFFSGVVRG ESAMQSERDV
GSKVKYEVTV SNQGQSLNTL GSAFLNIMWP HEIANGKWLL YPMRVELEGG QGPGQRGLCS
PRPNILHLDV DSRDRRRREL GQPEPQEPHE QPEPSTSWWP VSSAEKKKNV TLDCTRGTAS
CVVFSCPLYS FDRAAVLHVW GRLWNSTFLE EYSAVKSLEV IVQANITVKS SIKNLLLRDA
STVIPVMVYL DPVAVVAEGV PWWVILLAVL AGLLVLALLV LLMWKCGFFH RNSQSSSFPT
NYHRARLAVQ PSAAEAGGPG TVGHQGRCPW SCTSGPSWSF SCCP
//
