ID A0A383ZY70_BALAS Unreviewed; 857 AA.
AC A0A383ZY70;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 {ECO:0000313|RefSeq:XP_007179874.1};
GN Name=AGAP2 {ECO:0000313|RefSeq:XP_007179874.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007179874.1};
RN [1] {ECO:0000313|RefSeq:XP_007179874.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007179874.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the centaurin gamma-like family.
CC {ECO:0000256|ARBA:ARBA00005430}.
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DR RefSeq; XP_007179874.1; XM_007179812.1.
DR AlphaFoldDB; A0A383ZY70; -.
DR STRING; 310752.A0A383ZY70; -.
DR KEGG; bacu:103017267; -.
DR CTD; 116986; -.
DR InParanoid; A0A383ZY70; -.
DR OrthoDB; 1449795at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08836; ArfGap_AGAP; 1.
DR CDD; cd04103; Centaurin_gamma; 1.
DR CDD; cd01250; PH_AGAP; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR45819:SF3; ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR45819; CENTAURIN-GAMMA-1A; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}.
FT DOMAIN 333..567
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 588..708
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 747..779
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 10..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 808..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..324
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..444
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 808..834
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 857 AA; 92130 MW; 9C1CD6026F814F9C CRC64;
MLKFISGIFT KSTGGPPGSG PPPGPPVLSS GSGSRELLGA ELRASPKAVV NSQEWTLSRS
IPELRLGVLG DARSGKSSLI HRFLTGSYQV LEKTESEQHK KEMLVDGQTH LVLIREEAGA
PDTKFSGWAD AVIFVFSLED ENSFQAVSRL HGQLSSLRGE GRGGLALALV GTQDRISASS
PRVVGDARAR ALCADMKRCS YYETCATYGL NVDRVFQEVA QKVVTLRKQQ QLLAACKSLP
SSPSHSAAST PVAGQASNGG HTSDYSSSLP SSPNVGHREL RAEAAAVAGL STPGSLHRAA
KRRTSLFANR RGSDSEKRSL DSRGETTGSG RAIPIKQSFL LKRSGNSLNK EWKKKYVTLS
SNGFLLYHPS INDYIHSTHG KEMDLLRTTV KVPGKRPPRA ISAFGPSASI NGLVKDMSTV
QMGEGPEATT PTPSPSPSPS SLQPPPDQTS KHLLKPDRNL ARALSTDCTP SGDLSPLSRE
PPPSPMVKKQ RRKKLTTPSK TEGSAGQAEA KRKMWKLKSF GSLRNIYKAE ENFEFLIVSS
TGQTWHFEAA SFEERDAWVQ AIESQILASL QCCESSKVKL RTDSQSEAVA IQAIRNAKGN
SICVDCGAPN PTWASLNLGA LICIECSGIH RNLGTHLSRV RSLDLDDWPR ELTLVLTAIG
NDMANRVWES DTRGRAKPTR DSSREERESW IRAKYEQLLF LAPLGTSEEP LGCQLWAAVQ
AQDVAAVLLL LAHARHGPLD TSPEDPQLRS PLHLAAELAH VVITQLLLWY GADVSARDAQ
GRTALFYARQ AGSQLCADIL LQHGCPGEGG STATTPSAAT TPSITATPSP RRRSSAASVG
RADVPVALVY DCKDTAA
//
