ID A0A384A096_BALAS Unreviewed; 2540 AA.
AC A0A384A096;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 08-NOV-2023, entry version 18.
DE SubName: Full=Ral GTPase-activating protein subunit alpha-1 isoform X4 {ECO:0000313|RefSeq:XP_007180777.1, ECO:0000313|RefSeq:XP_007180778.1};
DE SubName: Full=Ral GTPase-activating protein subunit alpha-1 isoform X5 {ECO:0000313|RefSeq:XP_007180779.1};
GN Name=RALGAPA1 {ECO:0000313|RefSeq:XP_007180777.1,
GN ECO:0000313|RefSeq:XP_007180778.1, ECO:0000313|RefSeq:XP_007180779.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007180778.1};
RN [1] {ECO:0000313|RefSeq:XP_007180777.1, ECO:0000313|RefSeq:XP_007180778.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007180777.1,
RC ECO:0000313|RefSeq:XP_007180778.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
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DR RefSeq; XP_007180777.1; XM_007180715.2.
DR RefSeq; XP_007180778.1; XM_007180716.1.
DR RefSeq; XP_007180779.1; XM_007180717.1.
DR GeneID; 103003490; -.
DR CTD; 253959; -.
DR OrthoDB; 21929at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR046859; RGPA/RALGAPB_N.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR PANTHER; PTHR10063:SF3; RAL GTPASE-ACTIVATING PROTEIN SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR Pfam; PF20412; RALGAPB_N; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000261681}.
FT DOMAIN 2300..2508
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 343..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 863..899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1033..1061
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1352..1410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1491..1510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..363
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..889
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2540 AA; 285054 MW; DEB375A3745D75CF CRC64;
MFSKKPHGDV KKSTQKVLDT KKDALTRLKH LRIVIENAES IDLKQFFDQH FSHIYYVFFE
NFVTIEASLK QKGHKSQREE LDAILFIFEK ILQLLPERIH QRWQFHSIGL ILKKLLHTGN
SLKIRREGVR LFLLWLQALQ NNCSKEQLWM FSCLIPGFSA PQSEYGPRTL DNLINPPLNL
QETQVTIEEI TPLVPPQSGD KGQEDLTSYF LEALLKYIVI QAKSLEWKNK ENQERGFSFL
FSHFKKYYLP YIFPNICKEN SLYHPVLDIP QMRPKPHYVM IKKDAETNEA IYCTKEPFIK
ARVIVIRWLV SFWLEPKPHT GPHIPGMEGE VLPKNIQRAA ASLVSREENK NDNADKTDRT
TEPEQSHSNT STLTEREPSS SSLCSIDEEH LTDIEIVRRV FSSKRSNVNF VTEIFRQAFL
LPICEAAAMR KVVKVYQEWI QQEEKPLFMQ EPEEIVISSS DLPCIDNVTD HDISMEEGEK
REEENGTSIA DHVRNSTWAK NGTYQDVLRN ASEEAIEQNI RAGAQAVLQV FIINSSNIFL
LEPANEIKNL LDEHTDMCKR ILNIYRFMVV QVSMDKKTWE QMLLVLLRVT ESVLKMPSQA
FLQFQGKKNM TLAGRLAGPL FQTLIVAWIK ANLNAYISRE LWDDLLSVLS SLTYWEELAT
EWSLTMETLT KVLARNLYSL DLSDLPLDKL SEQKQKKHKG KGVGHEFQKV SVDKSFSRGW
SRDQPGQAPM RQRSATTTGS PGTEKARSIV RQKTVAMRSR SIGECALPSA YIRSAKSAPV
LIHTSKPFLP DIVLTPLSDE LSDIDDAQIL PRSTRVRHFS QSEDTGNEVF GALSEEQPLP
RSSSTSDILE PFTVERAKGA VPVIDSSSRH APSLQSSTEA SSITRSTESH ITDTHSRESS
LEVGDSIYDH LCHLIDPVEL ADSAFEQIQY IDLEGDDDLL SSLKEYFKEN QESHSKNELG
KDAASQEVII AANRDERSSL DKLEHIDQES KSENTTSFVG TPENIQFQKE SNSAVFMNNS
APNQLDSFMR TKTSEKCKQL NSDKQSSEPS SGSPCDKEKR KHLYRQTATE LDACIDITLA
EKVKGMQINE KIIVPHVLHA KKTTLKAPVN HRMPHVTSTS KLSPTKRSLS ETVTHRAKIM
KIASKKRNSV HVTFRPSTES VQFYNPLESK EAPWKMRLRK LSGFSSSSNS SISSPHASSN
SVTELVKPGV YRPLDTASVS SKTIKESTEI PTAILQKEGI ASNQLGGSRS TIKSSSHEAG
LQQGSLGGVY KTVVHALSKP KANVSPQRQN RMPPEAPLRD LYSHVMGYFG RKAAVNKEDM
STKLPPLSSD IGSSNANVPD LMDEFIAERL RSGNASTMTR RGSSPGSLEI PKDLPDILNK
QNPMRPIDDP GVPSEWTSPA SAGSSDLISS DSHSDSFSAF QYDGRKFDNF GFGADTGNAS
SADVDSGSGH YQSAEEQEVA SLTTLHIDSE TSSLNQQAFC TEVATVTGSE SASPVHSALG
SRSQTPSPST LNIDHMEQKD LQLDEKLHHS VLQTPDDLEI SEFPSECCSV MAGGTLTGWH
ADVATVMWRR MLGILGDVNA IMDPEIHAQV FDYLCELWQN LAKIRDNLGI STDNLTSPSP
PVLIPPLRIL TPWLFKATML TDKYKQGKLH AYKLICNTMK RRQDVSPNRD FLTHFYNIMH
CGLLHIDQDI VNTIIKHCSP QFLSLGLPGA TMLIMDFIVA AGRVASSAFL NAPRVEAQVL
LGSLVCFPNL YCELPALHPN IPDIAVSQFT DVKELIIKTV LSSARDEPSG PARCVALCSL
GIWICEELVH ESHHPQIKEA LNVICVSLKF TNKTVAHVAC NMLHMLVHYV PRLQIYQPDS
PLKIIQILIA TITHLLPSTE ASSYELDKRL VVSLLLCLLD WIMALPLKTL LQPVHATGAE
NDKIEKSVLN CIYKVLHGCV YGSQCFSNPR YFPLSLSDLA SVDYDPFMHL ESLKEPEPLH
SPDSERSSKL QPVTEVKTQM QQGLISIAAR TVITHLVNHL GHYPMSGGPA MLTSQVCENH
DNHYSESTEL SPELFESPNI QFFVLNNTTL VSCIQIRSEE SIPGGGLSAG LASANSNVRI
IVRDLSGKYS WDSAILYGPP LVSGLSEPTS LILSLSHQEK PEEPSTSHEC LEDITVKDGV
SLQFRRRFRE TVPTWDTIRD EEDVLDELLQ YLGVTSPECL QRTGVSLNIP APQPVCISEK
QENDVINAIL KQHTEEKEFV EKHFNDLNMK AVEQDEPTPQ KPQSAFYYCR LLLSILGMNS
WDKRRSFHLL KKNEKLLREL RNLDSRQCRE THKIAVFYVA EGQEDKHSIL TNTGGSQAYE
DFVAGLGWEV NLTNHCGFMG GLQRNKSTGL TTPYFATSTV EVIFHVSTRM PSDSDDSLTK
KLRHLGNDEV HIVWSEHTRD YRRGIIPTEF GDVLIVIYPM KNHMFSIQIM KKPEVPFFGP
LFDGAIVNGK VLPIMVRATA INASRALKSL IPLYQNFYEE RARYLQTIVQ HHLEPTTFED
FAAQVFSPAP YHHLPSDADH
//
