ID A0A384A473_BALAS Unreviewed; 223 AA.
AC A0A384A473;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=DNA replication complex GINS protein SLD5 {ECO:0000256|ARBA:ARBA00014804, ECO:0000256|PIRNR:PIRNR007764};
GN Name=GINS4 {ECO:0000313|RefSeq:XP_007182155.1,
GN ECO:0000313|RefSeq:XP_028022292.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007182155.1};
RN [1] {ECO:0000313|RefSeq:XP_007182155.1, ECO:0000313|RefSeq:XP_028022292.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007182155.1,
RC ECO:0000313|RefSeq:XP_028022292.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- FUNCTION: Required for initiation of chromosomal DNA replication. Core
CC component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that
CC unwinds template DNA during replication, and around which the replisome
CC is built. {ECO:0000256|PIRNR:PIRNR007764}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR007764}.
CC -!- SIMILARITY: Belongs to the GINS4/SLD5 family.
CC {ECO:0000256|ARBA:ARBA00008187, ECO:0000256|PIRNR:PIRNR007764}.
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DR RefSeq; XP_007182155.1; XM_007182093.1.
DR RefSeq; XP_028022292.1; XM_028166491.1.
DR AlphaFoldDB; A0A384A473; -.
DR STRING; 310752.A0A384A473; -.
DR KEGG; bacu:103009800; -.
DR CTD; 84296; -.
DR InParanoid; A0A384A473; -.
DR OrthoDB; 1200818at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd11711; GINS_A_Sld5; 1.
DR CDD; cd21692; GINS_B_Sld5; 1.
DR Gene3D; 1.20.58.1030; -; 1.
DR Gene3D; 3.40.5.60; -; 1.
DR InterPro; IPR021151; GINS_A.
DR InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR InterPro; IPR008591; GINS_Sld5.
DR InterPro; IPR031633; SLD5_C.
DR InterPro; IPR038749; Sld5_GINS_A.
DR PANTHER; PTHR21206:SF0; DNA REPLICATION COMPLEX GINS PROTEIN SLD5; 1.
DR PANTHER; PTHR21206; SLD5 PROTEIN; 1.
DR Pfam; PF05916; Sld5; 1.
DR Pfam; PF16922; SLD5_C; 1.
DR PIRSF; PIRSF007764; Sld5; 1.
DR SUPFAM; SSF158573; GINS helical bundle-like; 1.
DR SUPFAM; SSF160059; PriA/YqbF domain; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR007764};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR007764};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681}.
FT DOMAIN 51..126
FT /note="GINS subunit"
FT /evidence="ECO:0000259|Pfam:PF05916"
FT DOMAIN 165..223
FT /note="DNA replication complex GINS protein SLD5 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF16922"
FT COILED 44..71
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 223 AA; 25991 MW; 15538763BDEEFEE4 CRC64;
MTEELDLSGQ DSDAGSEEVV LTPAELIDRL EQAWMNEKFA PELLENKSEI VDCVMEQLQH
MEENLRRAKK GDLKVSIHQM EMERIRFVLS SYLRCRLMKI EKFFPHVLEK EKTRREGEPS
SLSPEEFAFA REYMVNTETY LKNVALKHMP PNLQKVDLLR AVPKPDLDSY VFLRVKERQE
NILVEPETDE QRDYVIDLEE GSQHLIRYKT IAPLVASGAV QLI
//
