ID A0A384ABR7_BALAS Unreviewed; 1524 AA.
AC A0A384ABR7;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Rho guanine nucleotide exchange factor 5 isoform X2 {ECO:0000313|RefSeq:XP_007184728.1};
GN Name=ARHGEF5 {ECO:0000313|RefSeq:XP_007184728.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007184728.1};
RN [1] {ECO:0000313|RefSeq:XP_007184728.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007184728.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
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DR RefSeq; XP_007184728.1; XM_007184666.1.
DR CTD; 7984; -.
DR OrthoDB; 12272at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01221; PH_ephexin; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11940; SH3_ARHGEF5_19; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR029212; ARHGEF5/35_N.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047271; Ephexin-like.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047270; PH_ephexin.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12845:SF2; DH DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF15441; ARHGEF5_35; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1101..1285
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1317..1429
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1437..1498
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 102..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 882..993
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..333
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..686
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..729
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..794
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 914..944
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1524 AA; 166658 MW; 5A1785F10222BD1D CRC64;
MEAEEPQHGA STPVPARVEF SVILAAPMRS RQTPALEPEA EEGEDPSYQW AGRHTLLDTQ
QRHVRGVNDC ATESMTSFPI AASADVETNQ ENLMAEACHT PEHQEAGPQR PADRQARPPA
PPELWACPNQ GEYLDTASVS SELGSSMEVE FRPELSSLIL ETGQAEEEEE PSPDTSAQTR
CGPCCEERPA ETNQPQDSES GPARQGSPER EGAVCLQKAE ELEGEGQGGE RLQGAGTPRG
DVCSDGLSGE RVQMGEQVCG TEEEQRQKEQ QSQDDVMLAE QGESKGRSGE LGGLSSGEWD
WRTQGHGDLE RGEQKSGELT GPEESRVEAR YEENQSLVGK SVRVTGKQED QGLQGKVMPV
EGQEEKVGSS EEEPGGGHGD TPGGGGGERR TEEGGKHDVP AALALVAPEV SSPHDLFPDA
CCPTARIPGT QAEPRAEEPS PGAPTLELVG WSQQLISLPH SFPAAESPDQ ETAQYNQQVG
SELGKGTASS RGGEGVSATP PRTAVSASPS PPEVSPGMTA SSAGPQVAFP RREPSVAACS
PETSRASRPA DSPPPCGASE SAAAARHGFP SAGQASPHGP PGIRTGAAQH LRGNSLPGSH
GTEPTPDLEG ISLSFSHSEL PQRPPKPAIY GSVIPRRGRK SGRDCTIIPE SSSSLPTPGQ
DSQEFASNPA RPGSPQSSQP WASTHPSAFA PGSPARGSSP PTVSVDMRIR EPPPPPPPEK
RRVHSTAEGD GHRSAVVPTL RRQRYNKPLP PTPGLPQPQP SPVSSSRSSR IYKPLPPVPI
VTPPTEPPPL PPKSRERSSC TQGGLGNSGG EARTRPVCQE WTISTPHSVG RVSWPPATGR
STDSLVPASR SKSEVPPGMA FSNMTALVNP SFLTARWTLE VQGPTSKESE VSARRSLRRT
APQKGASGLR RSDLGRARQP EKPGHPHLEK ASSWPHRRDP GRPAEGSRGQ AVVPSEGSSK
HKHWHRQGLR RPSILPEGPS GGPAVEKSPS LSDAIVFREK KPKEVMGGFS RRCSKLINSS
QLLYQEYSDV FLNKEIQSQQ RLDSLTEAPE PASPRQPRKA LVSSESYLQR LSMASSGSLW
QEIPVVRNST VLLSMTHDDQ KLQEAKFELI VSEASYLRSL HIAVDHFQHS EQLRATLSNQ
DHQWLFSRLQ DVRDVSTMFL SDLEENFEGN IFTFQVCDVV LSHAANFRRV YLPYVTNQTY
QERTFQSLLN SNSSFREVLE KLESDPICQR LSLKSFLILP FQRITRLKLL LQNILKRTQP
GSSEEAEATK AHHALEELIR DCNNNVQRMR RTEELIYLSQ KIEFECRIFP LISQSRWLVK
SGELTALEFS ISPGLRRKLN ARPVHLHLFN DCLLLSRPRE GSRFLVFDHA PFSSVRGEKC
EMKLHGPHKN LFRLFLRDNA QGSQAEFLFR TETQSEKLRW ISALAMPREE LDLLECYESP
QVQCLRAYKP RENDELALEK ADVVMVTQQS SDGWLEGVRL SDGEQGWFPV QQVEFISNPE
VRARNLKEAH RVKTARLQLV EQET
//
