ID   A0A384AH18_BALAS        Unreviewed;      1037 AA.
AC   A0A384AH18;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Huntingtin-interacting protein 1 isoform X1 {ECO:0000313|RefSeq:XP_007186620.1};
GN   Name=HIP1 {ECO:0000313|RefSeq:XP_007186620.1};
OS   Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS   (Balaenoptera davidsoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC   Balaenopteridae; Balaenoptera.
OX   NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007186620.1};
RN   [1] {ECO:0000313|RefSeq:XP_007186620.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_007186620.1};
RG   RefSeq;
RL   Submitted (JAN-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the SLA2 family.
CC       {ECO:0000256|ARBA:ARBA00010135}.
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DR   RefSeq; XP_007186620.1; XM_007186558.1.
DR   AlphaFoldDB; A0A384AH18; -.
DR   STRING; 310752.A0A384AH18; -.
DR   GeneID; 103006605; -.
DR   KEGG; bacu:103006605; -.
DR   CTD; 3092; -.
DR   InParanoid; A0A384AH18; -.
DR   OrthoDB; 7775at2759; -.
DR   Proteomes; UP000261681; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR   GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR   GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR   CDD; cd17013; ANTH_N_HIP1; 1.
DR   Gene3D; 1.20.5.1700; -; 1.
DR   Gene3D; 1.25.40.90; -; 1.
DR   Gene3D; 6.10.250.920; -; 1.
DR   Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR   InterPro; IPR011417; ANTH_dom.
DR   InterPro; IPR013809; ENTH.
DR   InterPro; IPR008942; ENTH_VHS.
DR   InterPro; IPR032422; HIP1_clath-bd.
DR   InterPro; IPR035964; I/LWEQ_dom_sf.
DR   InterPro; IPR002558; ILWEQ_dom.
DR   InterPro; IPR030224; Sla2_fam.
DR   PANTHER; PTHR10407; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR   PANTHER; PTHR10407:SF14; HUNTINGTIN-INTERACTING PROTEIN 1; 1.
DR   Pfam; PF07651; ANTH; 1.
DR   Pfam; PF16515; HIP1_clath_bdg; 1.
DR   Pfam; PF01608; I_LWEQ; 1.
DR   SMART; SM00273; ENTH; 1.
DR   SMART; SM00307; ILWEQ; 1.
DR   SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR   SUPFAM; SSF109885; I/LWEQ domain; 1.
DR   PROSITE; PS50942; ENTH; 1.
DR   PROSITE; PS50945; I_LWEQ; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261681}.
FT   DOMAIN          32..160
FT                   /note="ENTH"
FT                   /evidence="ECO:0000259|PROSITE:PS50942"
FT   DOMAIN          771..1012
FT                   /note="I/LWEQ"
FT                   /evidence="ECO:0000259|PROSITE:PS50945"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1015..1037
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          377..590
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          978..1007
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1037 AA;  116485 MW;  3E00DD9C27E32B54 CRC64;
     MDRMTSSMKQ VPNPLPKVLS RRGVGAGMEA AERESFERTQ TVSINKAINT QEVAVKEKHA
     RTCILGTHHE KGAQTFWSVV NRLPLSSNAV LCWKFCHVFH KLLRDGHPNV LKDSLRYKNE
     LSDMSRMWGH LSEGYGQLCS IYLKLLRTKM EYHTKNPRFP GNLQMSDRQL DEAGESDVNN
     FFQLTVEMFD YLECELNLFQ TVFNSLDMSR SVSVTTAGQC RLAPLIQVIL DCSHLYDYTV
     KLLFKLHSCL PADTLQGHRD RFMEQFTKLK DLFYRSSNLQ YFKRLIQIPQ LPDNPPNFLR
     ASALSEHISP VVVIPAEASS PDSEPVLEKD DLMDMDASQQ NSYDSKFDDI FGSSSSSDPF
     NFNSQNGVNK DEKDHLIDQL YGEISGLKAQ LENMKTESHR AMLQLKGRIS ELEAELAEQQ
     HLRQQAADES EFLRAELDEL KKKREDTEKA QRSLTEIERK AQANEQRYSK LKEKYSELVQ
     NHADLLRKNA EVTKQVSVAR QAQVDLEREK KELEDSFQRI SDQAQRKTQE QTEVLESLKQ
     ELATSKQELH IVQGSLESSA QSEAKWTAQI AELEKERGRL VEAVACREEE LSSLREQLEY
     TQIKLSSAQE SVCRLAKDQR KMLLAESRRA AEQVVQEALR RFEEPTLFSC AGSADHLLST
     VRSVSSCIEQ LEKCWSQYLA CPEDISGLLH SVTLLAHLTG DTIVHGSTTC LRAPPEPADS
     LTEACKQYGR ETLTYLSFLE EEGIVENADS TAMRSCLARI TAIGEELLPR GLDIKQEELG
     DLVDKEMAAT SAAIETATAR IEEMLSKSRA GDTGVKLEVN ERILGSCTSL MQAIQVLIVA
     SKELQREIVE SGRGTASPKE FYAKNSRWTE GLISASKAVG WGATVMVDAA DLVVQGRGKF
     EELMVCSHEI AASTAQLVAA SKVKADKDSP NLTQLQQASR GVNQATAAVV ASTISGKSQI
     EDTDSMDFSS MTLTQIKRQE MDSQVRVLEL ENELQKERQK LGELRKKHYE LAGVAEGWEE
     GTEASPPTLQ EAITEKE
//