ID A0A384AHD6_BALAS Unreviewed; 730 AA.
AC A0A384AHD6;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Ras GTPase-activating protein 4 isoform X3 {ECO:0000313|RefSeq:XP_007186644.1, ECO:0000313|RefSeq:XP_007186647.1};
GN Name=LOC103012909 {ECO:0000313|RefSeq:XP_007186644.1,
GN ECO:0000313|RefSeq:XP_007186647.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007186644.1};
RN [1] {ECO:0000313|RefSeq:XP_007186644.1, ECO:0000313|RefSeq:XP_007186647.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007186644.1,
RC ECO:0000313|RefSeq:XP_007186647.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
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DR RefSeq; XP_007186644.1; XM_007186582.1.
DR RefSeq; XP_007186647.1; XM_007186585.1.
DR AlphaFoldDB; A0A384AHD6; -.
DR CTD; 100271927; -.
DR OrthoDB; 24454at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0071277; P:cellular response to calcium ion; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:InterPro.
DR CDD; cd04025; C2B_RasA1_RasA4; 1.
DR CDD; cd13372; PH_CAPRI; 1.
DR CDD; cd05395; RasGAP_RASA4; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR037777; RASA4_PH.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001562; Znf_Btk_motif.
DR PANTHER; PTHR10194:SF4; RAS GTPASE-ACTIVATING PROTEIN 4-RELATED; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00779; BTK; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00107; BTK; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51113; ZF_BTK; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00432}.
FT DOMAIN 44..160
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 229..439
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 493..600
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 677..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 730 AA; 81833 MW; 0C1A6116944325C4 CRC64;
MDEDALSRDD VIGKVCLTRD TLATQPKGFS GWAHLTEVDP DEEVQGEIHL RLEVVPGTRA
CRLRCSVLEA RDLAPKDRNG ASDPFVRVRY NGRTQETSIV KKSRYPRWNE TFEFELEEGA
AEALCVEAWD WDLVSRNDFL GKVVFNVQRL RAAQQEEGWF QLQPDQSKSQ REEGNLGSLQ
LEVRLRDEMV LPSGCYQPLV QLLCREVKLG TQSPGQLILL IEETTSTECR QDVATTLLKL
FLGQGLAKDF LDLLFQLELG RTSEANTLFR SNSLASKSME SFLKVAGMRY LHGVLGPIID
RVFEEKKYVE LDPSKVEVKD VGCSGLHRPQ TEAEVLEQSA QTLRAHLGAL LSSLSRSVRA
CPAVVRATFR QLFRRVRERF PSAQDENVPF IAVTSFLCLR FISPAIMAPK LFHLRERHAD
ARTSRTLLLL AKAVQNVGNM DTPASRAKEA WMEPLQPTVR QGVAQLKDFI TKLVDIQEKE
ELDLQRALSL QAPPVKEGPL FIHRTKGKGP LMSSSFKKLH FSLTTEALSF AKTPSSKKST
LIKLAHIRAA EKVEEKSFGS SHVMQVIYTD DAGRSQTAYL QCKCVNELNQ WLSALRKVSI
NNTGLLGSYH PGVFRGDKWS CCHQRDKTDL GCDKTRSRVT LQEWNDPLDH DLEAQLIYRH
LLGVEATLRE KHRQLSAGPE AGPVLPGPGG APEDPLAQLL QVLQDLREAH RSSPAGSPPL
EPSRVLELQT
//
