ID A0A384AHI0_BALAS Unreviewed; 719 AA.
AC A0A384AHI0;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN Name=SMURF1 {ECO:0000313|RefSeq:XP_007186780.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007186780.1};
RN [1] {ECO:0000313|RefSeq:XP_007186780.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007186780.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_007186779.1; XM_007186717.1.
DR RefSeq; XP_007186780.1; XM_007186718.2.
DR AlphaFoldDB; A0A384AHI0; -.
DR STRING; 310752.A0A384AHI0; -.
DR KEGG; bacu:103001429; -.
DR CTD; 57154; -.
DR InParanoid; A0A384AHI0; -.
DR OrthoDB; 5480520at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR CDD; cd08382; C2_Smurf-like; 1.
DR CDD; cd00078; HECTc; 1.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR024928; E3_ub_ligase_SMURF1.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR11254:SF293; E3 UBIQUITIN-PROTEIN LIGASE SMURF1; 1.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00397; WW; 2.
DR PIRSF; PIRSF001569; E3_ub_ligase_SMURF1; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 1..108
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 222..255
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 268..301
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 382..719
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 148..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 687
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001569-1,
FT ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 719 AA; 81815 MW; 28834FF7BBF88EF0 CRC64;
MKDSGKLLCA KNLAKKDFFR LPDPFAKIVV DGSGQCHSTD TVKNTLDPKW NQHYDLYVGK
TDSITISVWN HKKIHKKQGA GFLGCVRLLS NAISRLKDTG YQRLDLCKLN PSDTDAVRGQ
IVVSLQTRDR IGTGGSVVDC RGLLENEGTA YEDSGPGRPL SCFMEEPAPY TDGTGAAAGG
GGCRSVESPS QDQRLQAQRL RSSEVRGSLQ TPQNRPHGHQ SPELPEGYEQ RTTVQGQVYF
LHTQTGVSTW HDPRIPRDLN SVNCDELGPL PPGWEVRSTV SGRIYFVDHN NRTTQFTDPR
LHHIMNHQCQ LKEPSQPLPL PSEGSVEDEE LPAQRDERDL VQKLKVLRHE LSLQQPQAGH
CRIEVSREEI FEESYRQIMK MRPKDLKKRL MVKFRGEEGL DYGGVAREWL YLLCHEMLNP
YYGLFQYSTD NIYMLQINPD SSINPDHLSY FHFVGRIMGL AVFHGHYING GFTVPFYKQL
LGKPIQLSDL ESVDPELHKS LVWILENDIT PVLDHTFCVE HNAFGRILQH ELKPNGRNVP
VTEENKKEYV RLYVNWRFMR GIEAQFLALQ KGFNELIPQH LLKPFDQKEL ELIIGGLDKI
DLDDWKSNTR LKHCGADSNV VRWFWQAVET FDEERRARLL QFVTGSTRVP LQGFKALQGS
TGAAGPRLFT IHLIDANTDN LPKAHTCFNR IDIPPYESYE KLYEKLLTAV EETCGFAVE
//
