ID A0A384ARE6_BALAS Unreviewed; 1952 AA.
AC A0A384ARE6;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Rho GTPase-activating protein 21 isoform X1 {ECO:0000313|RefSeq:XP_007189945.1};
GN Name=ARHGAP21 {ECO:0000313|RefSeq:XP_007189945.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007189945.1};
RN [1] {ECO:0000313|RefSeq:XP_007189945.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007189945.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Cytoplasmic
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004284}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004284}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004395}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004395}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_007189945.1; XM_007189883.2.
DR STRING; 310752.A0A384ARE6; -.
DR KEGG; bacu:103018255; -.
DR CTD; 57584; -.
DR InParanoid; A0A384ARE6; -.
DR OrthoDB; 2997116at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01253; PH_ARHGAP21-like; 1.
DR CDD; cd04395; RhoGAP_ARHGAP21; 1.
DR Gene3D; 1.20.5.220; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23175:SF16; RHO GTPASE-ACTIVATING PROTEIN 21; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681}.
FT DOMAIN 56..165
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 935..1044
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1152..1344
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 736..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 790..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 912..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1092..1133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1360..1407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1423..1635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1648..1679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1701..1756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1770..1791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1857..1952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..811
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 914..931
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1100..1125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1381..1405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1432..1499
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1588..1602
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1606..1629
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1661..1679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1701..1725
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1866..1944
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1952 AA; 215911 MW; 8060ACADC0D5077E CRC64;
MMATRRTGLP EGDGDNKLKA CGSPACEVSK SKDGKEQSET VSPSEDETFS WPGPKTVMLK
RTSQGFGFTL RHFIVYPPES AIQFSYKDEE NGNRGGKQRN RLEPMDTIFV KQVKEGGPAF
EAGLCTGDRI IKVNGESVIG KTYSQVIALI QNSDTTLELS VMPKDEDILQ VLQFTKDVTA
LAYSQDAYLK GNEAYSGNAR NIPEPPLVCY PWLPPAPPAP VQPPETAPPD SSTSKPQASP
PVLTQPGRAY RMEIQVPPSP PEVAKSNTAV CVCSESVRTV IVPSEKVVDL LPNRSGHTVP
SHRTEEVRYG RSEQTSFKTA SRKTSPPSSI PTSHLIHQTG SRSLEPSGIL LKSGHYSGHS
EGLASSRSPA ADSPPVSVNH YSPNSHQHID WKNYKTYKEY IDNRRLHMGC RTIQERLDSL
RAASQSTTDY NQVVLNRAAL QIRRRSTSQD RVPQSVQIRQ RSVSQERLED SVLMKYCPRS
ASQGALTSPS ISFSNHRTHS WDYIEGQGET LENVHSECPP PDVKGERKQT YKWSGFTEQD
DRRGIYERHR QQEIHKSFRG SNFTVAPSVV NSDNRRVSGR GVELVSQFKR IPADLKPLQP
NRNFQTTCGM SQPRGISQDR SPLVKVRNNS LKAPMHVIKP PSSQNSFVSI KDQRPVNHLH
QNSLLNQQTW LRTESAPDHQ VDTGKPPSLS GASVKPTPPM SENAGTPDLE LSATQRIQDL
NLQEAEIQQS NAVDNKETVI LREKPPSGRQ TPQPLRHQSY ILAVNDQEPG SDTTCWLPND
ARREVHIKRM EERKASSTSP PSDSLASIPF IDEPTSPSID HDIPHIPASA LISASTSQVP
SIAAAPPSLT TSAPLIRRQL SHDQESVGPP SLDAQPSSKT ERSKSYDEGL DDYREDAKLS
FKHVSSLKGI KITDSQKSSE DSGSRKDSSS EVFSDAAKEG WLHFRPLVTD RGKRVGGSIR
PWKQMYVVLR GHSLYLYKDK REQTTPSEEE QPISVNACLI DISYSETKRK NVFRLTTSDC
ECLFQAEDRD DMLAWIKSIQ ESSNLNEEDT GVTNRDLISR RIKEYNSLMS SKAEQLPKTP
RQSLSIRQTL LGAKAEPRTQ SPHSPKEESE RKLLSKDDTS PPKDKGTWRK GIPSIMRKTF
EKKPTATGTF GVRLDDCPPA HTNRYIPLIV DICCKLVEER GLEYTGIYRV PGNNAAISSM
QEELNKGMAD IDIQDDKWRD LNVISSLLKS FFRKLPEPLF TNDKYADFIE ANRKEDPLDR
LKTLKRLIHD LPEHHYETLK FLSAHLKTVA ENSEKNKMEP RNLAIVFGPT LVRTSEDNMT
HMVTHMPDQY KIVETLIQHH DWFFTEEGAE EPLTTVQEEN TVDSQPVPNI DHLLTNIGRT
GVSPGDVSDS ATSDSTKSKG SWGSGKDQYS RDLLVSSIFA AASRKRKKPK EKAQPSSSED
ELDNVFFKKE NAEQGHNDIK EESKKESETP GRKQRTVACK ENHAKKDGSA ARADQRALRG
ETAEPPAPQG AKQSRSPTPS CRLAILKEGP RALAAQKASH PDETGPDSGA LARFSTKKST
SPEARVGEFL VSVGTITADD PATLPAPSVT GLDSSRLSPE VQSVAESRGD DADDERSELV
SEGRPVETDS ESDFPVFPAA LASERLLRGK LQEATKTSRR NSEGSEVSGT EGSLTPSLES
RRLLFSSHKL IECDTLSRKK SARFKSDSAT LGDAKNEKEA PSIAKVFEVM KKGKSTGSLL
TPPARSESEK QEPTWKTKIA DRLKLRPKAP ADDMFGVGTQ KTHADPAKRK NIKRRHTLGG
HRDATEISVL NFWRAQEQSG DRESELSAVT RLKPKCSAQD LSISDWLARE RLRTSTADLS
RGDAGDPQPQ SLSTLDIPTT DPALSSQSHA DSSPSTLAST NRPPLSTPPQ SLDQINGESF
QNTSQNASSA ATAQPHQLSE TPGSKAQFHP CL
//
