ID A0A384AVN3_BALAS Unreviewed; 1467 AA.
AC A0A384AVN3;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Latent-transforming growth factor beta-binding protein 1 isoform X3 {ECO:0000313|RefSeq:XP_007191457.1};
GN Name=LTBP1 {ECO:0000313|RefSeq:XP_007191457.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007191457.1};
RN [1] {ECO:0000313|RefSeq:XP_007191457.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007191457.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_007191457.1; XM_007191395.2.
DR CTD; 4052; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0031012; C:extracellular matrix; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019838; F:growth factor binding; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 12.
DR Gene3D; 2.10.25.10; Laminin; 17.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF43; LATENT-TRANSFORMING GROWTH FACTOR BETA-BINDING PROTEIN 4; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 13.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00683; TB; 4.
DR SMART; SM00181; EGF; 17.
DR SMART; SM00179; EGF_CA; 16.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 11.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 10.
DR PROSITE; PS01187; EGF_CA; 6.
DR PROSITE; PS51364; TB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 200..232
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 358..403
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 427..464
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 478..524
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 663..704
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 786..826
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 827..867
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 868..908
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 909..949
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 950..991
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 992..1029
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1093..1147
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1270..1323
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1408..1452
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 23..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 553..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 204..214
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 222..231
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1467 AA; 160222 MW; D9FBFD571FC08F9D CRC64;
MCLRPQLCVC KPGTKGKACE TTAAQDTSSP VFGGQSPVAA SSWVPPEQAA KHTSSKKADT
LPRVSPVAQM TLTLKPKPSV GLSQQIHSQV TPLSSQNVMI HHGQAQEYVL KPKYFAAQKV
ISGEQSTEGS FPLRFGHDHV AAPFQLSNHT GRIKVVFTPS ICKVTCTKGS CQNSCEKGNT
TTLISENGHA ADTLTATNFR VVICHLPCMN GGQCSSRDKC QCPPNFTGKL CQIPVHGASV
PKLYQHSQQS GKALGTHVVH STHTLPLTMT SQQGVKVKFP PNIVNIHVKH PPEASVQIHQ
VSRVDGPTSQ KVKEAQPGQS QVSYQGLPVQ KTQTVHSSYS HQQVIPHVYP VAAKTQLGRC
FQETIGSQCG KALPGLSKQE DCCGTVGTSW GFHKCQKCPK KPSYHGYNQM MECLQGYKRV
NNTFCQDINE CQLQGVCPNG ECLNTMGSYR CTCKIGFGPD PTFSSCVPDT PVISEEKGPC
YRLVSSGRQC MHPLSVHLTK QLCCCSVGKA WGPHCEKCPL PGTAKEEPVE ALTFSREQGP
GAAEPEVATV PPEKEIPSLD QEKTKLEPSQ PQLSPGISTI HLHPQFPVVI EKTSPPVPVE
VAPEASTSSA SQVIAPTQVT EINECTVNPD ICGAGHCINL PVRYTCICYD GYKFSEQQRK
CVDIDECAQA QHLCSQGRCE NTEGSFLCIC PAGFMASEEG TNCIDVDECL RPDVCGEGHC
VNTVGAFRCE YCDSGYRMTP GGHCEDVDEC LTPSTCPDEQ CVNSPGSYQC VPCTEGFRGW
NGQCLDVDEC LEPDICTNGT CSNLEGSYMC SCHKGYTPTP DHKHCKDVDE CQQGNLCING
QCKNTEGSFR CTCGQGYQLS ATKDQCEDID ECQHRHLCSN GQCRNTEGSF RCVCDQGYRA
SALGDHCEDI NECLEDNSVC QGGDCINTEG SYDCTCPDGF QLNDNKGCQD INECEQPGLC
GPHGECLNTD GSFHCVCEQG FSISADGHTC EDIDECVNNT VCDSHGFCDN TAGSFRCLCY
QGFQAPQDGQ GCVDVNECEL LSGVCGEAFC ENVEGSFLCV CVDENQEYSP MTGQCRSRAS
ADLEVDQPKE EKKECYYNLN DASLCDNVLA PNVTKQECCC TSGAGWGDNC EIFPCPVLGT
AEFTEMCPRG KGFVPTGESS YDVDGENYKD ADECLLFGQE ICKNGFCLNT QPGYECYCKQ
GTYYDPVKLQ CFDIDECQDP NSCIDGQCVN TEGSYNCFCT HPMVLDASEK RCIRPTESHE
QIEETDVYQD LCWEHLSDEF VCSRPLVGKQ TTYTECCCLY GEAWGMQCAL CPMKNSDDYA
QLCNIPVTGR RQPYGQDALV DFSEQYAPEA DPYFIQDRFL NSFEELQAEE CGILNGCENG
RCVRVQEGYT CDCFDGYHLD MAKMTCVDVN ECDELNNRMS LCKNAKCINT EGSYKCVCLP
GFVPSDKPNY CTPLNTALNL EKDSDLE
//
