ID A0A384AW70_BALAS Unreviewed; 1634 AA.
AC A0A384AW70;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Sodium channel protein type 5 subunit alpha isoform X1 {ECO:0000313|RefSeq:XP_007191518.1, ECO:0000313|RefSeq:XP_007191519.1};
GN Name=SCN5A {ECO:0000313|RefSeq:XP_007191518.1,
GN ECO:0000313|RefSeq:XP_007191519.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007191518.1};
RN [1] {ECO:0000313|RefSeq:XP_007191518.1, ECO:0000313|RefSeq:XP_007191519.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007191518.1,
RC ECO:0000313|RefSeq:XP_007191519.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
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DR RefSeq; XP_007191518.1; XM_007191456.1.
DR RefSeq; XP_007191519.1; XM_007191457.1.
DR KEGG; bacu:103007817; -.
DR CTD; 6331; -.
DR OrthoDB; 1110761at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 3.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR008053; Na_channel_a5su.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF206; SODIUM CHANNEL PROTEIN TYPE 5 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR01666; NACHANNEL5.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000313|RefSeq:XP_007191518.1,
KW ECO:0000313|RefSeq:XP_007191519.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 127..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 717..735
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 747..768
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 780..797
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 837..860
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 880..897
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 917..940
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1206..1225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1246..1262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1274..1295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1323..1349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1445..1471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1560..1578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 130..422
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 508..667
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 717..946
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 954..1201
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1205..1480
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1529..1607
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 27..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 567..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 997..1144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 413..444
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 27..51
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..507
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..526
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1055..1069
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1073..1117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1129..1144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1634 AA; 184401 MW; 9E08CA8B8933B572 CRC64;
MADFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSAASQ ESRDRLPEEE APQPQLDLQA
SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK TIFRFSATNA LYVLSPFHPI
RRAAMKILVH SLFSMLIMCT ILTNCVFMAQ HDPPPWTKYV EYTFTAIYTF ECLVKVLARG
FCLHAFTFLR DPWNWLDFSV IIMAYTTEFV DLGNVSALRT FRVFRALKTI SVISGLKTIV
GALIQSVRKL ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTVLSGT NGSVEADGLV
WESLDLYLND PENYLLKNGT SDVLLCGNSS DAGTCPEGYR CLKAGENPDH GYTSFDSFAW
AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG SFYLVNLILA VVAMAYEEQN
QATIAETEEK EKRFQEAMEM LKKEHEALAI RGVDTVSRSS LEMSPLAAVT SHERRSKRRK
RMSSGSEECG DDRFPKSDSE DGPRAVKHLS ITHGLSRTSL KPRSSHGSIF TFRRRDMGSE
TDFADDENST AGDSESHRTS LLVPWPLRRP SAQGQPSPGS STPSHVLNGK RNSTVDCNGV
VSLLGAGDPE ATSPGSRLLR PMMLERPLDT TTPSEEPGRP QMLNPQAPCV DGFEEPGERQ
RALSAVSVLT SVLEELESHR KYPPCWNRFA QRYLIWECCP LWMSIKQRVK VMVMDPFADL
TITLCIVINT LFMALEHYNM TTEFEEMLQV GNLVFTGIFT AEMTFKIIAL DPYYYFQQGW
NIFDSIIVIL SLMELGLSRM GNLSVLRSFR LLRVFKLAKS WPTLNTLIKI IGNSVGALGN
LTLVLAIIVF IFAVVGMQLF GKNYSELRHR ISDSGLLPRW HMMDFFHAFL IIFRILCGEW
IETMWDCMEV SGQSLCLLVF LLVMVIGNLV VLNLFLALLL SSFSADNLTA PDEDGEMNNL
QLALARIQRG LRFIKRTTWD FCCGLLQRRA QKPAALATQG QLPGCITTSS PPPPPETEKA
LPARKETRFE EGQRPGQGTP GDPEPVCVPI AVAESDTDDQ EEDEENSLST EEESSKQQEP
QPVSGSPQAL PEPRPWSQVS ETTSSGAEAS AAQADLRQQR RTEAPAPGCS ETHENSYSEG
STADMTNTAD LLEQIPDLGE DIKDPEDCFT KGCVRRCPCC TVDTTQAPGK VWWRLRKTCY
HIVEHSWFET FIIFMILLSS GALAFEDIYL EERKTIKVLL EYADKMFTYI FVLEMLLKWV
AYGFKKYFTN AWCWLDFLIV DVSLISLVAN ALGFAEMGPI KSLRTLRALR PLRALSRFEG
MRVVVNALVG AIPSIMNVLL VCLIFWLIFS IMGVNLFAGK FGRCINQTEG DLPLNYTIVN
NKSDCVSFNV TGELYWTKVK VNFDNVGAGY LALLQVATFK GWMDIMYAAV DSRGYEEQPQ
WEYNLYMYIY FVIFIIFGSF FTLNLFIGVI IDNFNQQKKK LGGQDIFMTE EQKKYYNAMK
KLGSKKPQKP IPRPLNKYQG FIFDIVTKQA FDVTIMFLIC LNMVTMMVET DDQSPEKVNI
LTKINLLFVA IFTGECIIKM AALRHYYFTN SWNIFDFVVV ILSIVGPSLD PASTDLCLGV
TGFHLSAMFR PCLQ
//
