ID A0A384AWT7_BALAS Unreviewed; 1539 AA.
AC A0A384AWT7;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=CLIP-associating protein 2 isoform X6 {ECO:0000313|RefSeq:XP_007191574.1};
GN Name=CLASP2 {ECO:0000313|RefSeq:XP_007191574.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007191574.1};
RN [1] {ECO:0000313|RefSeq:XP_007191574.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007191574.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Golgi apparatus, trans-Golgi network
CC {ECO:0000256|ARBA:ARBA00004601}.
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DR RefSeq; XP_007191574.1; XM_007191512.2.
DR GeneID; 102998033; -.
DR CTD; 23122; -.
DR OrthoDB; 5478662at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:UniProt.
DR GO; GO:0008017; F:microtubule binding; IEA:UniProt.
DR GO; GO:0051494; P:negative regulation of cytoskeleton organization; IEA:UniProt.
DR GO; GO:1902904; P:negative regulation of supramolecular fiber organization; IEA:UniProt.
DR GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IEA:UniProt.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF30; CLIP-ASSOCIATING PROTEIN 2; 1.
DR Pfam; PF21040; CEP104-like_TOG; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 1.
DR SMART; SM01349; TOG; 4.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 4: Predicted;
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 7..232
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 168..206
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 325..558
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 893..1130
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1292..1532
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 244..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 748..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..884
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1119..1176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1197..1268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..790
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 869..884
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1120..1176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1203..1218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1233..1268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1539 AA; 168149 MW; C6366CA76683B694 CRC64;
MEPRCMEYFS AQVQQKDVGG RLQVGQELLL YLGVPGAIPD LEEDLGCLGR TVDALTGWVG
SSNYRVSLMG LEILSAFVDR LSTRFKSYVA MVIVALIDRM GDAKDKVRDE AQTLILKLMD
QVAPPMYIWE QLASGFKHKN FRSREGVCLC LIETLNIFGA QPLVLSKLVP HLCILFGDSN
SQVRDAAILA VVEIYRHVGE KVRVDLCKRG IPLARLEMIL GKFDEVQNSG GMILSACKDK
SFDDEESVDG NRPSSAASAF KVPAPKTSGN PVNSARKPGS XXXXXXXXAG GPKVGGASKE
GGAGAVDEDD FIKAFTDVPS IQIYSSRELE ETLNKIREIL SDDKHDWDQR ANALKKIRSL
LVAGAAQYDG FFQHLRLLDG ALKLSAKDLR SQVVREACIT VAHLSTVLGN KFDHGAEAIV
PTLFNLVPNS AKVMATSGCA AIRFIIRHTH VPRLIPLITS NCTSKSVPVR RRSFEFLDLL
LQEWQTHSLE RHAAVLVETI KKGIHDADAE ARVEARKTYM GLRNHFPGEA ETLYNSLEPS
YQKSLQTYLK SSGSVASLPQ SDRSSSSSQE SLNRPFSSKW STANPSTVAG RVSAGSSKAS
SLPGSLQRSR SDIDVNAAAG AKAHHAAGQA VRSGRLGAGA LNPGSYASLE DTSDKMDGTA
SEDGRVRAKL SAPLAGMGNS KTDSRGRSRT KMVSQSQRSS SPDKNEGSQS ANTIGAGSRS
GSPGRVLTTT ALSTVSSGVQ RVLVNSASAQ KRSKIPRSQG CSREASPSRL SVARSSRIPR
PSVSQGCSRE ASRESSRDTS PVRSFQPLGP GYGISQSSRL SSSVSAMRVL NTGSDVEEAV
ADALLLGDIR TKKKPARRRY ESYGMHSDDD ANSDASSACS ERSYSSRNGS IPTYMRQTED
VAEVLNRCAS SNWSERKEGL LGLQNLLKNQ RTLSRVELKR LCEIFTRMFA DPHGKVFSMF
LETLVDFIQV HKDDLQDWLF VLLTQLLKKM GADLLGSVQA KVQKALDVTR ESFPNDLQFN
ILMRFTVDQT QTPSLKVKVA ILKYIETLAK QMDPGDFINS SETRLAVSRV ITWTTEPKSS
DVRKAAQSVL ISLFELNTPE FTMLLGALPK TFQDGATKLL HNHLRNTGNG TQGSMGSPLT
RPTPRSPANW SSPLTSPTNT SQNTLSPSAF DYDTENMNSE DIYSSLRGVT EAIQNFSFRS
QEDMNEPLKR DSKKDEGDST CGGPGMSDPR AGGDATDSSQ TALDNKASLL HSMPAHSSPR
SRDYNPYNYS DSISPFNKSA LKEAMFDDDA DQFPDDLSID HSDLVAELLK ELSNHNERVE
ERKIALYELM KLTQEESFSV WDEHFKTILL LLLETLGDKE PTIRALALKV LREILRHQPA
RFKNYAELTV MKTLEAHKDP HKEVVRSAEE AASVLATSIS PEQCIKVLCP IIQTADYPIN
LAAIKMQTKV IERVSKETLN LLLPEIMPGL IQGYDNSESS VRKACVFCLV AVHAVIGDEL
KPHLSQLTGS KMKLLNLYIK RAQTGSGGAD PTTDVSGQS
//
