ID A0A384AZF3_BALAS Unreviewed; 1520 AA.
AC A0A384AZF3;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=FYVE, RhoGEF and PH domain-containing protein 5 isoform X1 {ECO:0000313|RefSeq:XP_007192693.1};
GN Name=FGD5 {ECO:0000313|RefSeq:XP_007192693.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007192693.1};
RN [1] {ECO:0000313|RefSeq:XP_007192693.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007192693.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR RefSeq; XP_007192693.1; XM_007192631.1.
DR STRING; 310752.A0A384AZF3; -.
DR GeneID; 102998954; -.
DR KEGG; bacu:102998954; -.
DR CTD; 152273; -.
DR InParanoid; A0A384AZF3; -.
DR OrthoDB; 5385125at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15742; FYVE_FGD5; 1.
DR CDD; cd15792; PH1_FGD5; 1.
DR CDD; cd13237; PH2_FGD5_FGD6; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF13; FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 5; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 950..1142
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1171..1265
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1306..1359
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 1421..1519
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 913..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..350
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1520 AA; 165176 MW; 8871154DE469B95E CRC64;
MNRADSPKPP VAPKPKAASP LTPVTAPKFP SSPRPESLHS PNSMSRGPKP PIAPKPRLAT
PSEWRASIYM INSLNKCSNG KLPCVDRGLY DEHRSTPECS EPEADEDYIV APRAPPAEDG
PSDGGSVENA VTVPPEGSGG EECQERGEEC EQEGAAAAED WAAPAEAVLS GEGDGGITPT
PEDMEVEDCA CDSGAEEQKF TSEEEEKQVE EHSVYSLEDG GPGDGEVVLP SDIILSHLDA
EDPAARGEEP GPPVTPGESE EDGEEGRTST ELGAPDECVG SDGPAERDAA DGGEEPPENE
GLATGVPEVE AATDSPDISQ EACEDAPGGG GQDGQDEPPD QKEKTDLEET AVVTQEAGED
PQEGEDPVQD EGAEESCQII PFERDFVDDF VAPLSGRPYE FFPSESTSFC SESCSPYSES
AQSLESEQEP RSGERAEQDP VAGPGCGRRG SLQGGAREGP SVPDVVVMPE EEGAADDALA
NPYEMGVGLA CGADPGEGEK PEAQAASDTA SGCGLKEEVN SDAEGGLVPI DRKNVITRAR
PHSGKMAGCV PETVPEETGP EAGSSAIGIG GATKEARKAV LSLEGKLLDV GRALPAKPRA
FTLYPRSFSV EGREIPLSLC REPEACGLDG HGIKRKDDNL SLPCMIGSSG SFSQRGHLPS
SGTSTPSSVV DIPPPFDLAC ITKKPITKSS PSLLVESEPP DKHTKKKKPS FKRFLALTFK
KKTESKVHVD VNVSSSRSSS ESSYHGPARL LEMDRRSLSN SPQLKARTGK LRACDSPSSL
IFYRDGKRKG VPFSRTVSRV ESFEDLSRPP FLPLPLTKPR SISFPNADTS DYENIPAMNS
DYENIQIPPR RPPRAGTFTK LFEDQSRALS TANENDGYVD MSSFNAFESK QQSADQEAES
AYTEPYKVCP ISAVAPKEDL TSDEERGSSE EEDSASGDPS LTHKVDGQSR AHVIAQELLS
SEKAYVEMLQ HLHLDFHGAV MGALDEMDQE GKDTLAREEL RRGLSELPPI RDLHQGILEE
LEERLSHWES QQKVADVFLA REQEFEHHAA HIQQFDRYLS LLGENCLHAP RLAAAVREFE
QSQQGGGQNV KHRLLRVVQR LFQYQVLLTD YLNNLCPDSA EYDNTQGALS LISKVTDRAN
DSMEQGENLQ KLVHIEHSVR GQGDLLQPGR EFLKEGTLMK VTGKNRRPRH LFLMSDVLLY
TYPQKDGKYR LKNALAVASM KVSRPVMEKV PYALKIETSE SCLTLSASSC AERDEWHSCL
SRALPEDYKA QALAAFQHSV EIRERLGVSL GERPPTLVPV THVMMCMNCG CDFSLTLRRH
HCHACGKIVC RNCSRNKYPL KYLKDRMAKV CDGCYGELKK RGGDIPGLMR GRPVSMSFPL
SSTRFSSSAF SSVFQSINPS AFKKQKKVPS ALTEVAASGE GSAISGYLSR CKKGKRHWKK
LWFVIKGKVL YTYMASEDTV ALESMPLLGF TIAPEKEEGS SEVGPIFHLY HKKTLFYSFK
AEDTNSAQRW IEAMEDASVL
//
