ID   A0A384B000_BALAS        Unreviewed;       764 AA.
AC   A0A384B000;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Hypoxia-inducible factor 1-alpha {ECO:0000256|ARBA:ARBA00014446};
GN   Name=HIF1A {ECO:0000313|RefSeq:XP_007193021.1};
OS   Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS   (Balaenoptera davidsoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC   Balaenopteridae; Balaenoptera.
OX   NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007193021.1};
RN   [1] {ECO:0000313|RefSeq:XP_007193021.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_007193021.1};
RG   RefSeq;
RL   Submitted (JAN-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   RefSeq; XP_007193021.1; XM_007192959.2.
DR   AlphaFoldDB; A0A384B000; -.
DR   GeneID; 103008124; -.
DR   CTD; 3091; -.
DR   OrthoDB; 5396877at2759; -.
DR   Proteomes; UP000261681; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd00130; PAS; 2.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR001321; HIF-1_alpha.
DR   InterPro; IPR014887; HIF-1_CTAD.
DR   InterPro; IPR021537; HIF_alpha-like.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR013655; PAS_fold_3.
DR   NCBIfam; TIGR00229; sensory_box; 2.
DR   PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR   PANTHER; PTHR23043:SF7; HYPOXIA-INDUCIBLE FACTOR 1-ALPHA; 1.
DR   Pfam; PF11413; HIF-1; 1.
DR   Pfam; PF08778; HIF-1a_CTAD; 1.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF08447; PAS_3; 1.
DR   PRINTS; PR01080; HYPOXIAIF1A.
DR   SMART; SM00086; PAC; 1.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50112; PAS; 2.
PE   4: Predicted;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261681}.
FT   DOMAIN          34..99
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          188..239
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   REGION          435..462
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          580..626
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        435..457
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        587..607
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         343
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
FT   MOD_RES         505
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
FT   MOD_RES         741
FT                   /note="(3S)-3-hydroxyasparagine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
SQ   SEQUENCE   764 AA;  85553 MW;  BF91140A7797E159 CRC64;
     MRLTISYLRV RKLLDAGDLD IEDEMKAQMN CFYLKALDGF VMVLTDDGDM IYISDNVNKY
     MGLTQFELTG HSVFDFTHPC DHEEMREMLT HRNGLVKKGK EQNTQRSFFL RMKCTLTSRG
     RTMNIKSATW KVLHCTGHIH VYDTNSNQSQ CGYKKPPMTC LVLICEPIPH PSNIEIPLDS
     KTFLSRHSLD MKFSYCDERI TELMGYEPEE LLGRSIYEYY HALDSDHLTK THHDMFTKGQ
     VTTGQYRMLA KRGGYVWVET QATVIYNTKN SQPQCIVCVN YVVSGIIQHD LIFSLQQTEC
     VLKPVESSDM KMTQLFTKVE SEDTSSLFDK LKKEPDALTL LAPAAGDTII SLDFGSNDTE
     TDDQQLEEVP LYNDVMLPSS NEKLQNINLA MSPLPASETP KPLRSSADPA LNQEVALKLE
     PNPESLELSF TMPQIQDQPA SPSDGSTRQS SPEPNSPSEY CFDVDSDMVN EFKLELVEKL
     FAEDTEAKNP FSTQDTDLDL EMLAPYIPMD DDFQLRSFDQ LSPLESSSTT PQSASTITVF
     QPTQMQEPPI TTNTTTATTD ELKTVTKDGM EDIKILIAFP SPPHVPKETT CATTSPYSDT
     GSRTASPNRA GKGVIEQTEK SHPRSPNVLS VALSQRTTVP EEELSPKILA LQNAQRKRKI
     EHDGSLFQAV GIGTLLQQPD DRATTTSLSW KRVKGCKSSE QNGMEQKTII LIPSDLACRL
     LGQSMDESGL PQLTSYDCEV NAPVQGSRNL LQGEELLRAL DQVN
//