ID A0A384B2L5_BALAS Unreviewed; 1870 AA.
AC A0A384B2L5;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Neurogenic locus notch homolog protein 4 isoform X4 {ECO:0000313|RefSeq:XP_007193956.1};
GN Name=NOTCH4 {ECO:0000313|RefSeq:XP_007193956.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007193956.1};
RN [1] {ECO:0000313|RefSeq:XP_007193956.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007193956.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NOTCH family.
CC {ECO:0000256|ARBA:ARBA00005847}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_007193956.1; XM_007193894.2.
DR GeneID; 103008998; -.
DR CTD; 4855; -.
DR OrthoDB; 5473534at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0050793; P:regulation of developmental process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 19.
DR Gene3D; 3.30.300.320; -; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 26.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR008297; Notch.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR022355; Notch_4.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR010660; Notch_NOD_dom.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR24044:SF489; NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00008; EGF; 15.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF12661; hEGF; 3.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF07684; NODP; 1.
DR Pfam; PF00066; Notch; 3.
DR PIRSF; PIRSF002279; Notch; 3.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01452; LNOTCHREPEAT.
DR PRINTS; PR01983; NOTCH.
DR PRINTS; PR01987; NOTCH4.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00181; EGF; 29.
DR SMART; SM00179; EGF_CA; 23.
DR SMART; SM00004; NL; 3.
DR SMART; SM01338; NOD; 1.
DR SMART; SM01339; NODP; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 12.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF90193; Notch domain; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 9.
DR PROSITE; PS00022; EGF_1; 27.
DR PROSITE; PS01186; EGF_2; 21.
DR PROSITE; PS50026; EGF_3; 27.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS50258; LNR; 3.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Calcium {ECO:0000256|PIRSR:PIRSR002279-1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR002279-2};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1870
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017021377"
FT DOMAIN 22..61
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 62..113
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 116..152
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 153..189
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 191..229
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 231..271
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 273..309
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 311..350
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 352..388
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 389..427
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 429..470
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 472..508
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 510..546
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 548..584
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 586..622
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 688..724
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 726..762
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 764..800
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 803..839
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 841..877
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 890..925
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 927..963
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 965..1001
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1003..1041
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1043..1082
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1084..1123
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1127..1168
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1167..1210
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1211..1247
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1248..1292
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT REPEAT 1630..1662
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1663..1685
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1697..1729
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1343..1372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1480..1505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1731..1870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1358..1372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1856..1870
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 452
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 455
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 472
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 475
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 489
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 511
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 513
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 527
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT DISULFID 51..60
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 103..112
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 120..130
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 142..151
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 179..188
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 219..228
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 261..270
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 299..308
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 340..349
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 378..387
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 398..415
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 417..426
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 433..449
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 443..458
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 460..469
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 476..487
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 481..496
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 498..507
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 514..525
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 519..534
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 536..545
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 574..583
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 612..621
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 714..723
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 752..761
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 790..799
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 829..838
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 867..876
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 915..924
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 953..962
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 991..1000
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1012..1029
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1031..1040
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1072..1081
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1113..1122
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1158..1167
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1870 AA; 195883 MW; 15B6F9CCFD1EC2DD CRC64;
MQPPSLLLPL LLLLCRSVVQ TRGLQCGSFP EPCANGGTCL SLSQGQGTCQ CAPGFLGETC
QFPDPCQDAQ LCQNGGSCQA LLPTLPSSPS LPSPLAPSFF CTCPSGFTGD RCQAQLKDPC
ASFCSKMGRC HIQASGRPQC SCMPGWTGEH CQLRDFCSAN PCVNGGVCLA TYPQIQCRCP
PGFEGHACER DVNECFLDPG PCPKGTSCHN TLGSFQCLCP AGWGGPRCEL RPGPCPPRGC
PSGGTCQVVP GRDSTFHLCL CPPGFTGPSC EVNPDDCVGH QCQNGGTCQD GLGTYTCLCP
EAWTGWDCSE DVDECEVQGL PRCRNGGTCQ NSAGGFHCVC VSGWGGTGCE ENLDDCVAAT
CAPGSTCIDR VGSFSCLCPP GRTGLLCHME DMCLSQPCHQ EAQCNTNPLR GSTFCVCQPG
YTGPTCHQDL DECQMAQQGP SPCEHGGSCL NTPGSFECLC PPGYTGSRCE ADHNECLSQP
CHPGSTCLDL LATFQCLCPP GLEGQLCEVE TDECASAPCL NEADCQDLLN GFRCVCRPGF
TGSRCEEDIN ECRSSPCANG GQCQDQPGSF HCKCLPGFEG PRCQAEVDEC LSGPCPTGAS
CLDLPGAFLC LCPSGFTGHL CEIPLCAPNL CQPKQRCQDP EEEAHCLCPS GSPGCAPAED
NCTCHHGHCQ RSSCVCDVGW TGPECDTELG GCVSTPCAHG GTCHPQPFGY NCTCATGYTG
PTCSEELTAC HSGPCLNGGS CSPSPEGYSC TCPPSHTGLR CQTSIDHCAS APCLHGGTCV
NRPSASSCLC TTGFQGPRCE GRIRPSCADS PCRNRATCQD GPQGPRCLCP PGYTGGSCQT
LMDSCAQKPC PHNSHCLQTG PSFQCLCLQG WTGPLCNLPL SSCQKAALSQ GTEVSSLCQN
GGICIDSGPS HFCHCPPGFQ GSICQERVNP CESRPCQHGA TCVAQPNGYL CQCTPGYSGQ
NCSKEPDACQ SQPCHNHGTC TPKPGGFHCA CPPGFVGLRC EGDVDECLDQ PCHPTGTAAC
HSLANAFYCQ CLPGHTGQRC EVELDPCQSQ PCSHGGSCEA TAGPPPGFTC HCPQGFEGPT
CSHRAPSCGL HHCHHGGLCL PSPKPGFPPR CACLNGYGGP DCLTPPAPPG CGPPSPCLHN
GSCSETPGLG GPGFRCSCPP SSPGPRCQRP GAKGCEGRSG DGACDAGCSG PGGNWDGGDC
SLGVPDPWKG CPSHSRCWLL FRDGQCHPQC DSEECLFDGY DCETPPACTP AYDQYCRDHF
HNGHCEKGCN TAECGWDGGD CRPEDGDSEW GPSLALLVVL SPSTLDQQLL ALARVLSLTL
RVGLWVRKDS DGRNMVYPYP GAQAEEELGG TPDPSHHERA APQTQPTGKE TDSLSTGFVV
VMDVDLSRCG PDHPASRCPW DPGLLLRFLA AMAAVGALEP LLPGPLLAAH PRAGTEPPAN
QLPWPVLCSP VAGVLLLALG ALLVLQLIRR KRREHGALWL PPGFTRRSQT QPVPRRRRPP
LGEDSIGLKA LKPEAEVDED GVVMCSGPKE GEEADQVEEM ASPSKCQLWP LSSDCQELPQ
AAMLTPPQDS EMDVPDVDTR GPDGVTPLMS AVCCGGVESR TYQETWLGSP EPWEPLLGGG
ACPQVHTVGT GETPLHLAAR FSRPTAARRL LEAGADPNQP DRAGRTPLHT AVAADAREVC
QLLLRSRQTA VDARTEDGTT ALMLAARLAV EDLVEELIAA QADVGARDKW GADAAVPGGP
RRSHGGSPAA AGAGSRPRAA GPSRASARGH RPPAQPLGSA DAAGRGGTTG GSSQSHAGPR
RRRLAARADR IRKRAPAWGR GSAALPDAVS RSLSSSPDFV RRLGRPWGRG LFALPKPIER
SRRRPAPPRP
//
