ID A0A384B2P7_BALAS Unreviewed; 1342 AA.
AC A0A384B2P7;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Adhesion G protein-coupled receptor F5 isoform X5 {ECO:0000313|RefSeq:XP_007193902.1};
GN Name=ADGRF5 {ECO:0000313|RefSeq:XP_007193902.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007193902.1};
RN [1] {ECO:0000313|RefSeq:XP_007193902.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007193902.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR RefSeq; XP_007193902.1; XM_007193840.1.
DR CTD; 221395; -.
DR OrthoDB; 3876300at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008078; GPCR_2_Ig-hepta-like_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR PANTHER; PTHR45813:SF3; ADHESION G-PROTEIN COUPLED RECEPTOR F1; 1.
DR PANTHER; PTHR45813; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF01390; SEA; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01695; IGHEPTARCPTR.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82671; SEA domain; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS50024; SEA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_007193902.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1342
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016772747"
FT TRANSMEM 1010..1037
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1049..1071
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1091..1113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1125..1147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1167..1195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1216..1236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1242..1265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 166..273
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 274..368
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 471..561
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1008..1266
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 1342 AA; 148607 MW; 861AFB5B56187CA7 CRC64;
MKSPRRTTLC FMIIVIVSSQ ATLNLNFESI VYPSLLHEHE LAGEDPVRQK RAVAMSRPAA
QEFTVDVEVS FEDASFLELS KAYLNNLSFP VQGDDTDPAT NILSIEVTTV CRPTGNETWC
SCEKGYKWPQ ERCLHNLTCQ GHDGFPSGHH CSCLKGLPPK GPFCQLQGDI TLRMSVRLNV
GFQEELRNSS SALYRSYKTD LETAFREGYS ILPGFKLVTV TEFRPGSVVV VYEVTTSAAS
PELMRRANEQ VTQNINQTYK MDSSSFQVTY SNETKFSITP EIILEGDTVT LMCENEVLSS
NVSWQHVETG FDVQNSSRFS VYTYVLNNMT SVSRLTIYNI TQDDAGEYIC KLTLDIFEYG
SRKKIDVTSI QILANEDMKV MCDNNPVSLS CCSEMTVNWS QVEWKQEGTI NIPGSPETDT
DSGCSRYTLT ADGTQCPSGL SGTTVVYTCE FISAHGARGS KDIKVTFTSV ANLKITPDPI
SVSEGQSFSI KCISDVSNYD EVYWNTSAGI KIYKRFYTTR RYPNGAESVL TVKTSTREWN
GTYHCIFRYK NSYSVMAKDV TVHPLPLEPD IMVDPLEAVI PCTSSRHIKC CIEEDRDYKV
IFQAGSSSFP AAKEVNGKQV CYKHHFVANS ISCPENMDVF CHITNTANNS VRSPSMKLNL
VPGENVTCQD PIIGVGEPGK VIQKLCQFSN VPRIPGSPIG GIITYRCVGS QWKVKKNNCI
SAPINTLLQL AEALMKSPSQ DAKLPSYLKN LSISTNQVKL EVNSFPGSLG AIINILDLLS
TVPTQVNSEM MMHVLSTVNV ILGKPILNTW MTSQQQKTNQ SSQLLHSVER FSQALRSEDS
TISQPNVQMK SMVIKSGHPK SYAQSFVFLD SDLWGNVTIN ECQLEHLQPD SFIVTVAFPT
LKTILAQDVP GKTFANSLVM TTIVSQNITT PFRISMTFKN NNPSGGVPRC VFWNFNLANH
TGGWDSSGCY VKEVTEDSVS CSCDHLTSFS ILMSPDSPDP DSLLKILLDI ISYIGLCFSI
LSLAACLAVE AVVWKSVTKN RTSSMRHICI VNIAASLLVA DVWFIVAAAI HNYRYPLNQT
ACVAATFFVH FSYLSVFFWM LTLGLMLFYR LVFILHDTSK SIQKAIAFSL GYGCPLVISV
ITVGATQPRE VYTRKNACWL NWEDTKALLA FVIPALIIVV VNVTITVVVI TKILRPSIGD
KPSKQEKSSL FQITKSIGVL TPLLGLTWGF GLATVFQGSN AVFHIVFTLL NAFQGLFILL
FGCLWDQKVQ EALLNKFSLS RWSSQHSKST SLGSSTPVFS MSSPISRRFN NLFGKTGTYN
VSTPEITSSS LENTSSAYSL LN
//
