ID A0A384B3U4_BALAS Unreviewed; 781 AA.
AC A0A384B3U4;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Glucocorticoid receptor {ECO:0000256|ARBA:ARBA00015625};
DE AltName: Full=Nuclear receptor subfamily 3 group C member 1 {ECO:0000256|ARBA:ARBA00031162};
GN Name=NR3C1 {ECO:0000313|RefSeq:XP_007194225.1,
GN ECO:0000313|RefSeq:XP_007194226.1, ECO:0000313|RefSeq:XP_007194227.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007194225.1};
RN [1] {ECO:0000313|RefSeq:XP_007194225.1, ECO:0000313|RefSeq:XP_007194226.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007194225.1,
RC ECO:0000313|RefSeq:XP_007194226.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Cytoplasm,
CC cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186}. Mitochondrion
CC {ECO:0000256|ARBA:ARBA00004173}. Nucleus
CC {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC subfamily. {ECO:0000256|ARBA:ARBA00005413}.
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DR RefSeq; XP_007194225.1; XM_007194163.2.
DR RefSeq; XP_007194226.1; XM_007194164.2.
DR RefSeq; XP_007194227.1; XM_007194165.2.
DR RefSeq; XP_007194228.1; XM_007194166.1.
DR AlphaFoldDB; A0A384B3U4; -.
DR STRING; 310752.A0A384B3U4; -.
DR KEGG; bacu:103020860; -.
DR CTD; 2908; -.
DR InParanoid; A0A384B3U4; -.
DR OrthoDB; 5305911at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0004883; F:nuclear glucocorticoid receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0005496; F:steroid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd07172; NR_DBD_GR_PR; 1.
DR CDD; cd07076; NR_LBD_GR; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR001409; Glcrtcd_rcpt.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR48092:SF5; GLUCOCORTICOID RECEPTOR; 1.
DR PANTHER; PTHR48092; KNIRPS-RELATED PROTEIN-RELATED; 1.
DR Pfam; PF02155; GCR; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00528; GLCORTICOIDR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 422..497
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 528..762
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 781 AA; 86067 MW; 58976EA0BCD4CD47 CRC64;
MDPKESLSPP SREEIPSSVL GRERGNVMDF YKTLRGGATV KVSASSPSLA AASQADSKQQ
RLLVDFPKGS GSNAQQPDLS KAVSLSMGLY MGETETKVMG NDLGFPQQGQ MSLSSGETDF
RLLEESIANL NRSTSVPENP KNSASAAASA APTEKEFPKT HSDVSSEQQN LKGQTGTNGG
NVKLYTTDQS TFDIWRKKLQ DLEFSSGSPG KETSESPWSS DLLIDENCLL SPLAGEDDPF
LLEGNSKEDR KPLVLPDTKP KIKDNGDLIL SSPNSVPLPQ VKTEKEDFIE LCTPGVIKQE
KLGPVYCQAS FSGANIIGNK MSAISVHGVS TSGGQMYHYD MNTASLSQQQ DQKPIFNVIP
PIPVGSENWN RCQGSGDDNL TSLGTLNFSG RSVFSNGYSS PGMRPDVSSP PSSSSAATGP
PPKLCLVCSD EASGCHYGVL TCGSCKVFFK RAVEGQHNYL CAGRNDCIID KIRRKNCPAC
RYRKCLQAGM NLEARKTKKK IKGIQQATTG VSQETSENSA NKTIVPATLP QLTPTLVSLL
EVIEPEVIYA GYDSSIPDTT WRIMTTLNML GGRQVIAAVK WAKAIPGFRN LHLDDQMTLL
QYSWMFLMSF ALGWRSYRQS SSNLLCFAPD LIINEQRMAL PCMYDQCKHM LYVSSELNRL
QVSYEEYLCM KTLLLLSSVP KEGLKSQELF DEIRMTYIKE LGKAIVKREG NSSQNWQRFY
QLTKLLDSMH DVVENLLNYC FQTFLDKTMS IEFPEMLAEI ITNQIPKYSS GNIKKLLFHQ
K
//
