ID A0A384B7K0_BALAS Unreviewed; 1179 AA.
AC A0A384B7K0;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Integrin alpha-2 {ECO:0000313|RefSeq:XP_007195637.1};
GN Name=ITGA2 {ECO:0000313|RefSeq:XP_007195637.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007195637.1};
RN [1] {ECO:0000313|RefSeq:XP_007195637.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007195637.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR RefSeq; XP_007195637.1; XM_007195575.1.
DR AlphaFoldDB; A0A384B7K0; -.
DR STRING; 310752.A0A384B7K0; -.
DR GeneID; 103016586; -.
DR KEGG; bacu:103016586; -.
DR CTD; 3673; -.
DR InParanoid; A0A384B7K0; -.
DR OrthoDB; 3816176at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0009986; C:cell surface; IEA:UniProt.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF23; INTEGRIN ALPHA-2; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 5.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 28..1179
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5016484388"
FT TRANSMEM 1132..1154
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 32..90
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 172..359
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 364..418
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 474..537
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 538..596
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 600..662
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1179 AA; 129188 MW; 067E98A9CF5B757C CRC64;
MRPGRTGGTL LRLVLVLNQG ILNCCVAYNV GLPEAKIFSG PSSEQFGYAV QQFINPEGNW
LLVGSPWSGF PENRMGDVYK CPVDLSTTTC EKLNLQTSTS ISNVTEMKTN MSLGLTLTRN
VGTGGFLTCG PLWAQQCGSQ FYTTGLCSDV SPNFQLLTSF SPAVQTCPSL IDVVVVCDES
NSIYPWDAVK NFLEKFVQGL DIGPTKTQVG LIQYANYPRV VFNLNTFKTK DGMIKATSQT
SQYGGDLTNT FKAIQYARDS AYSAAAGGRP GATKVMVVVT DGESHDGSML KAVIDQCNND
NILRFGIAVL GYLNRNALDT KNLIKEIKAI ASIPTERYFF NVSDEAALLE KAGTLGEQIF
SIEGTVQGGD NFQMEMSQVG FSADYSPQND ILMLGAVGAY DWSGTVVQQT PHGHLIFPKQ
AFDQILQDRN HSSYLGYSVA SISTGKSVHF VAGAPRANYT GQIVLYNVNE SGNITVIQSH
RGDQIGSYFG SVLCAVDVDK DTITDVLLVG APMYMNDLKK EEGRVYLFTI TKGVLNWHQF
LEGPEGVENA RFGSAIAALS DINMDGFNDV IVGSPLENQN SGAVYIYNGH EDTIRLRYSQ
KILGSDGAFR SHLQYFGRSL DGYGDLNGDS ITDVSVGAFG QVILLWSQSI ADVSVVASFT
PEKITLLNKN AEINLKLCFS AKFRPAKQNN QVAIVYNITI DADQYSSRVT SRGLFKENNE
RCLQKTTIVN QAQSCSEYII HIQEPSDVVS SLDLCVNISL ENPGTNPALE AYSETVKVFS
IPFYKDCGDD GVCISDLVLH VQQLPAAQQQ PFIVSNQNKR LTFSVTLKNK KESAYNSGIV
VDFSENLFFA SWSMPVDGTE VTCQIASSQK SVTCNVGYPA LKREQQVTFT INFDFNLQNL
QNQASVSFQA LSESYEENKA DNSVNFKLSL LYDAEIHITR STNINFYEVS SDGNIPSIVN
NFEDIGPKFI FSVKVTTGSV PVSMASVIIH IPQYTKGKNP LMYLTGVHTD QAGDISCKAE
INPLKIGQTS SSVSFKSENF RHVKELNCRT ASCSNVTCWL KDLQVKGEYF LNVSTRIWNG
TFAVSAFQTV QLTAAAEIDT YNPQIYAIEE NTITIPITIM KPHEKAEVPT GVIVGSAIAG
ILLLLALVAI LWKLGFFKRK YEKMAKNPDE IDETTELNS
//