UniProt: A0A384B7K0

Database: UniProt
Entry: A0A384B7K0_BALAS

LinkDB:  A0A384B7K0_BALAS 
Original site:  A0A384B7K0_BALAS

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Ontology (5)   
   GO (5)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (19)   
   InterPro (10)   
   Pfam (4)   
   PROSITE (3)   
   SMART (2)   
All databases (27)   

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ID   A0A384B7K0_BALAS        Unreviewed;      1179 AA.
AC   A0A384B7K0;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Integrin alpha-2 {ECO:0000313|RefSeq:XP_007195637.1};
GN   Name=ITGA2 {ECO:0000313|RefSeq:XP_007195637.1};
OS   Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS   (Balaenoptera davidsoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC   Balaenopteridae; Balaenoptera.
OX   NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007195637.1};
RN   [1] {ECO:0000313|RefSeq:XP_007195637.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_007195637.1};
RG   RefSeq;
RL   Submitted (JAN-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC       ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC   -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC       {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR   RefSeq; XP_007195637.1; XM_007195575.1.
DR   AlphaFoldDB; A0A384B7K0; -.
DR   STRING; 310752.A0A384B7K0; -.
DR   GeneID; 103016586; -.
DR   KEGG; bacu:103016586; -.
DR   CTD; 3673; -.
DR   InParanoid; A0A384B7K0; -.
DR   OrthoDB; 3816176at2759; -.
DR   Proteomes; UP000261681; Unplaced.
DR   GO; GO:0009986; C:cell surface; IEA:UniProt.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR   Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR   Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR   Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR   Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR   Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013517; FG-GAP.
DR   InterPro; IPR013519; Int_alpha_beta-p.
DR   InterPro; IPR000413; Integrin_alpha.
DR   InterPro; IPR018184; Integrin_alpha_C_CS.
DR   InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR   InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   InterPro; IPR032695; Integrin_dom_sf.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR   PANTHER; PTHR23220:SF23; INTEGRIN ALPHA-2; 1.
DR   Pfam; PF01839; FG-GAP; 2.
DR   Pfam; PF20805; Integrin_A_Ig_2; 1.
DR   Pfam; PF20806; Integrin_A_Ig_3; 1.
DR   Pfam; PF00092; VWA; 1.
DR   PRINTS; PR01185; INTEGRINA.
DR   PRINTS; PR00453; VWFADOMAIN.
DR   SMART; SM00191; Int_alpha; 5.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR   SUPFAM; SSF69179; Integrin domains; 3.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51470; FG_GAP; 5.
DR   PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW   ECO:0000256|RuleBase:RU003762};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003762};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU003762}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT   CHAIN           28..1179
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT                   /id="PRO_5016484388"
FT   TRANSMEM        1132..1154
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT   REPEAT          32..90
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   DOMAIN          172..359
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REPEAT          364..418
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          474..537
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          538..596
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          600..662
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ   SEQUENCE   1179 AA;  129188 MW;  067E98A9CF5B757C CRC64;
     MRPGRTGGTL LRLVLVLNQG ILNCCVAYNV GLPEAKIFSG PSSEQFGYAV QQFINPEGNW
     LLVGSPWSGF PENRMGDVYK CPVDLSTTTC EKLNLQTSTS ISNVTEMKTN MSLGLTLTRN
     VGTGGFLTCG PLWAQQCGSQ FYTTGLCSDV SPNFQLLTSF SPAVQTCPSL IDVVVVCDES
     NSIYPWDAVK NFLEKFVQGL DIGPTKTQVG LIQYANYPRV VFNLNTFKTK DGMIKATSQT
     SQYGGDLTNT FKAIQYARDS AYSAAAGGRP GATKVMVVVT DGESHDGSML KAVIDQCNND
     NILRFGIAVL GYLNRNALDT KNLIKEIKAI ASIPTERYFF NVSDEAALLE KAGTLGEQIF
     SIEGTVQGGD NFQMEMSQVG FSADYSPQND ILMLGAVGAY DWSGTVVQQT PHGHLIFPKQ
     AFDQILQDRN HSSYLGYSVA SISTGKSVHF VAGAPRANYT GQIVLYNVNE SGNITVIQSH
     RGDQIGSYFG SVLCAVDVDK DTITDVLLVG APMYMNDLKK EEGRVYLFTI TKGVLNWHQF
     LEGPEGVENA RFGSAIAALS DINMDGFNDV IVGSPLENQN SGAVYIYNGH EDTIRLRYSQ
     KILGSDGAFR SHLQYFGRSL DGYGDLNGDS ITDVSVGAFG QVILLWSQSI ADVSVVASFT
     PEKITLLNKN AEINLKLCFS AKFRPAKQNN QVAIVYNITI DADQYSSRVT SRGLFKENNE
     RCLQKTTIVN QAQSCSEYII HIQEPSDVVS SLDLCVNISL ENPGTNPALE AYSETVKVFS
     IPFYKDCGDD GVCISDLVLH VQQLPAAQQQ PFIVSNQNKR LTFSVTLKNK KESAYNSGIV
     VDFSENLFFA SWSMPVDGTE VTCQIASSQK SVTCNVGYPA LKREQQVTFT INFDFNLQNL
     QNQASVSFQA LSESYEENKA DNSVNFKLSL LYDAEIHITR STNINFYEVS SDGNIPSIVN
     NFEDIGPKFI FSVKVTTGSV PVSMASVIIH IPQYTKGKNP LMYLTGVHTD QAGDISCKAE
     INPLKIGQTS SSVSFKSENF RHVKELNCRT ASCSNVTCWL KDLQVKGEYF LNVSTRIWNG
     TFAVSAFQTV QLTAAAEIDT YNPQIYAIEE NTITIPITIM KPHEKAEVPT GVIVGSAIAG
     ILLLLALVAI LWKLGFFKRK YEKMAKNPDE IDETTELNS
//

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