ID A0A384B813_BALAS Unreviewed; 725 AA.
AC A0A384B813;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial isoform X1 {ECO:0000313|RefSeq:XP_007195419.1};
GN Name=MCCC1 {ECO:0000313|RefSeq:XP_007195419.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007195419.1};
RN [1] {ECO:0000313|RefSeq:XP_007195419.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007195419.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
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DR RefSeq; XP_007195419.1; XM_007195357.1.
DR AlphaFoldDB; A0A384B813; -.
DR STRING; 310752.A0A384B813; -.
DR GeneID; 103018095; -.
DR KEGG; bacu:103018095; -.
DR CTD; 56922; -.
DR InParanoid; A0A384B813; -.
DR OrthoDB; 1129179at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.700.40; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR18866; CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR18866:SF33; METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000261681}.
FT DOMAIN 48..494
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 167..364
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 626..715
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
SQ SEQUENCE 725 AA; 80392 MW; DF71E40F66996173 CRC64;
MAAASALSVL LVAAERSRWR RVPSSLLPPR GWTWKQRAMK YATTTGRNIT KVLIANRGEI
ACRVIRTAKK MGVQSVAVYS EADRNSMHVD MADEAHSIGP APSQQSYLSM EKIIQVAKIS
AAQAIHPGYG FLSENMEFAE LCKQEGIIFI GPPSSAIRDM GIKSTAKSIM AAAGVPVVEG
YHGDDQSDQC LKEHARRIGY PVMIKAVRGG GGKGMRIIRS EKEFQEQLES ARREAKKSFN
DDAMLIEKFV DTPRHVEVQV FGDHHGNAVY LFERDCSVQR RHQKIIEEAP GPGIKPEVRK
KLGEAAVRAA KAVNYVGAGT VEFIMDSKHN FYFMEMNTRL QVEHPVTEMI TGTDLVEWQL
RIAAGEKIPL SQEEITLRGH AFEARIYAED PNNNFMPGAG PLVHLSTPRA DLATRIETGV
RQGDEVSVHY DPMIAKLVVW AADRQAALTK LRYSLRQYSI VGLHTNIDFL LKLSGHPEFE
AGNVHTDFIP QHRKELLPHR KTTAKEFLCQ AALGLILKEK AMTDVFKIQT QDQYSPFVSS
SGRRLNICFT RNMTLRDGKN NVAIAVTYNR DGSHSMQIED KTFHVLGDLC SEGDCTYLKS
SVNGVASKTK LIILENTIYL FSMDGSIQIG IPVPRYLSSV SSEGTQGGAV APMTGTVEKV
FVKAGDKVKA GDSLMVMIAM KMEHTIKAPK DGTIKKVFYE EGAQANRHAP LVEFEEEESD
KREAE
//
