ID A0A384B9W0_BALAS Unreviewed; 654 AA.
AC A0A384B9W0;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Zinc transporter ZIP12 {ECO:0000256|ARBA:ARBA00040591};
DE AltName: Full=Solute carrier family 39 member 12 {ECO:0000256|ARBA:ARBA00042541};
DE AltName: Full=Zrt- and Irt-like protein 12 {ECO:0000256|ARBA:ARBA00042971};
GN Name=SLC39A12 {ECO:0000313|RefSeq:XP_007196467.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007196467.1};
RN [1] {ECO:0000313|RefSeq:XP_007196467.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007196467.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00034634};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|ARBA:ARBA00006939}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_007196467.1; XM_007196405.1.
DR AlphaFoldDB; A0A384B9W0; -.
DR STRING; 310752.A0A384B9W0; -.
DR GeneID; 103015010; -.
DR KEGG; bacu:103015010; -.
DR CTD; 221074; -.
DR InParanoid; A0A384B9W0; -.
DR OrthoDB; 5488029at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR003689; ZIP.
DR InterPro; IPR049406; ZIP4_12_EF-hand.
DR InterPro; IPR041137; ZIP4_N.
DR PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR PANTHER; PTHR12191:SF4; ZINC TRANSPORTER ZIP12; 1.
DR Pfam; PF21116; EF-hand_Zip; 1.
DR Pfam; PF02535; Zip; 1.
DR Pfam; PF18292; ZIP4_domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..654
FT /note="Zinc transporter ZIP12"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016938140"
FT TRANSMEM 367..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 564..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 595..613
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 625..648
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..222
FT /note="Zinc transporter ZIP4 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18292"
FT DOMAIN 230..346
FT /note="Zinc transporter ZIP4/12 EF-hand"
FT /evidence="ECO:0000259|Pfam:PF21116"
SQ SEQUENCE 654 AA; 72944 MW; 30D5E865FB3B0D2A CRC64;
MCFWRKLSVF WVPLFLLLSL IPLTETEKPS TPDSSGTWSP GQLMEILHVL SAQEPTPLNH
SRSLIRTLLE KTGCPRRTHG RQGDCNLCFD PDALLLIAGG DFEDQLREEV VQRVSLLLLY
YIIHQEEICS SKLNMSNKEY TFYLHSLLSL RQDEDSYFLS QNETEDILAF TRQYFDTSRS
QCMETKVLQK KSGVSSSDGA DENTLPQLAE TIIALSLQGV CLGQRNLPSP DYFTEYIFSS
LNSTNTLHLS ELDQLLNTLW TKNTCIRKDR LHQLQRKQNN LTIHDWAYPN GSVSKDPGSD
DSPISWAQTC FSAGQLVEIF LQNKLPAISK EDFKQMSPGI IQQLLSCSCH LPQDQQAKLP
PPTPEKYGYS TMAVTLLTLG SMLGTTLILF HCCEENYRLI LQLFVGLAVG TLSGDALLHL
IPQVLGLHKQ EASEFGHFHE NKGHIWKLLG LIGGIHGFFL IEKCFILLVS PSAEKGPEDA
QAVEIPIGSL NTPNRKCKTI SLLAIMILVG DSLHNFADGL VIGAAFSSSS ESGVTTTIAI
LCHEIPHEMG DFAVLLSSGL PIKIAILMNF ISALTAFIGL YIGLSVSTDP CIQNWILTVT
AGMFLYLSLV EMLPEMTHVQ TQRPWFMFLL QNFGLSLGWL SLLLLAIYEQ NIKI
//
