ID A0A384BAM8_BALAS Unreviewed; 717 AA.
AC A0A384BAM8;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Macrophage-expressed gene 1 protein {ECO:0000256|ARBA:ARBA00021365};
DE AltName: Full=Perforin-2 {ECO:0000256|ARBA:ARBA00030728};
GN Name=MPEG1 {ECO:0000313|RefSeq:XP_007196558.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007196558.1};
RN [1] {ECO:0000313|RefSeq:XP_007196558.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007196558.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004439}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004439}. Cytoplasmic vesicle, phagosome
CC membrane {ECO:0000256|ARBA:ARBA00004265}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004265}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MPEG1 family.
CC {ECO:0000256|ARBA:ARBA00007256}.
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DR RefSeq; XP_007196558.1; XM_007196496.2.
DR STRING; 310752.A0A384BAM8; -.
DR KEGG; bacu:103015655; -.
DR CTD; 219972; -.
DR InParanoid; A0A384BAM8; -.
DR OrthoDB; 4221421at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR CDD; cd22579; MPEG1_P2; 1.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR039707; MPEG1.
DR PANTHER; PTHR31463; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1.
DR PANTHER; PTHR31463:SF4; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00457; MACPF; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 3: Inferred from homology;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00023130};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT TRANSMEM 656..677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..345
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
SQ SEQUENCE 717 AA; 78884 MW; 17034CE436C128D9 CRC64;
MNSLRDAILI WAVAAWAKMN KSLGDTDEDG FQKCRNXXXX PVLAVLPGGG WDNLRNVDMG
RVMSLTYTHC RTTEDGQYIV PDEVFTIPQK ESNLEMNSKI LESWENYQSS TSYSINMELS
LFSKVNGKFS PEFQRMKTLQ VKDQAVTTQV QVRNLVYTVK INPDAELSWG FKKDLMDIAE
RLENNQTRMA TYLAELLVLN YGTHVITSVD AGAALIQEDH IRSSLLQDSQ SSRSAVTASA
GITFLNIVNF KFEENYTSQN AFTKSYLSNR TNSRVQSIGG LPFYPGITLQ TWQQGITNHL
VAMDRAGLPL YFFINPDRLP DLPGPLVKKL SKTVGTAVRC YYAFNTYPGC TDIKSPNFNF
QANMDDGSCE GKMTNFSFGG VYQECTQFSG NEVVQLCQNL EQKNPLTGDF SCPSGYTPVQ
LLSQTHEEGY NHLECSQKCT LLIFCKRVCE DVFRVAKAEF RAFWCVASGQ VPENSGLLFG
GLFSGKSINP LTNAQSCPAG YFPLRLFENL KVCASQDYEL GYRFSVPFGG FFSCAVGNPL
VDSAMYKDLG APSLKKCPGG FSQHLALISD GCQVSYCVKA GLFTGGSLPP VRLPPYTQPP
LMSQAATNTV LVTNLETASS WVKDSQSHQW RLGEPLELRR AMKVIHGDGS GLSGGAAAGV
TLGVTTVLAA VIALAIYGTR KYKKRGYQAV QDERQSLVTG TVVNGDALDQ EQVQSPA
//
