ID A0A384BEM5_BALAS Unreviewed; 720 AA.
AC A0A384BEM5;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Engulfment and cell motility protein 3 isoform X1 {ECO:0000313|RefSeq:XP_007198161.1};
GN Name=ELMO3 {ECO:0000313|RefSeq:XP_007198161.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007198161.1};
RN [1] {ECO:0000313|RefSeq:XP_007198161.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007198161.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC phagocytosis of apoptotic cells and cell motility. Acts in association
CC with DOCK1 and CRK. Was initially proposed to be required in complex
CC with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC nucleotide exchange factor (GEF) activity of DOCK1.
CC {ECO:0000256|ARBA:ARBA00024863}.
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DR RefSeq; XP_007198161.1; XM_007198099.1.
DR AlphaFoldDB; A0A384BEM5; -.
DR STRING; 310752.A0A384BEM5; -.
DR GeneID; 103003867; -.
DR KEGG; bacu:103003867; -.
DR CTD; 79767; -.
DR InParanoid; A0A384BEM5; -.
DR OrthoDB; 4872856at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR CDD; cd13359; PH_ELMO1_CED-12; 1.
DR Gene3D; 6.10.250.810; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024574; ELMO_ARM.
DR InterPro; IPR006816; ELMO_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR PANTHER; PTHR12771:SF16; ENGULFMENT AND CELL MOTILITY PROTEIN 3; 1.
DR Pfam; PF11841; ELMO_ARM; 1.
DR Pfam; PF04727; ELMO_CED12; 1.
DR Pfam; PF16457; PH_12; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51335; ELMO; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT DOMAIN 307..479
FT /note="ELMO"
FT /evidence="ECO:0000259|PROSITE:PS51335"
SQ SEQUENCE 720 AA; 81405 MW; 1EBE06A668FAE1A0 CRC64;
MAPPRNVVKI AVQMRDAIPQ LIQLDQAKPL AAVLKEVCDA WSLPHSERYA LQFADGHRRY
ITENNRTEIK NGSILCLSTA PDLEAERLLH GLQSESCEGR REALRHLVLL APDMTFTREV
ISRDGLQRLG SIIEDGDDLG EVLALALRAF LELMEHGVVS WETLSIPFVR KVVCYVNMNL
MDASVQPLAL GLLESVTLSS PALGQLVKSE VPLDRLLVHL QVMNQQLQTK AMALLTALLQ
GASAAERKHM LDYLWQRNLR QFIYKNIIHS AAPLGDEMAH HLYVLQALTL GLLEPRMRTP
LDPYSQEQRE QLQALRQAAF EPEGESLGTG LSADRRRSLC AREFRKLGFS NSNPAQDLER
VPPGLLALDN MLYFSRHAPS AYSRFVLENS SREDKHECPF ARSSIQLTVL LCELLHVGEP
CSETAQDFSP MFFGQDQSFH ELFCVSIQLL NKTWKEMRAT QEDFDKVMQV VREQLARTLA
LKPSSLELFR TKVNALTYGE VLRLRQTERL HQEGTLAPPI LELREKLKPE LMGLIRQQRL
LRLCEGTLFR KISSRRRQDK LWFCCLSPNH KVLQYGDVEE GVGPPAPESL PEQLPVADIR
ALLTGKDCPH VREKGSGKQN KDVCELAFSV SYDHGEEEAY LNFIAPSKRE FHLWTDGLSA
LLGSPMGSEQ TRLDLEQLLT METKLRLLEL ENVPIPEQPP PVPPPPTNFN FCYDCSIAEP
//