ID A0A384BG25_BALAS Unreviewed; 538 AA.
AC A0A384BG25;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Y+L amino acid transporter 2 {ECO:0000256|ARBA:ARBA00039563};
DE AltName: Full=Solute carrier family 7 member 6 {ECO:0000256|ARBA:ARBA00042899};
DE AltName: Full=y(+)L-type amino acid transporter 2 {ECO:0000256|ARBA:ARBA00042001};
GN Name=SLC7A6 {ECO:0000313|RefSeq:XP_007198227.1,
GN ECO:0000313|RefSeq:XP_007198228.1, ECO:0000313|RefSeq:XP_007198229.1,
GN ECO:0000313|RefSeq:XP_007198230.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_007198229.1};
RN [1] {ECO:0000313|RefSeq:XP_007198227.1, ECO:0000313|RefSeq:XP_007198228.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007198227.1,
RC ECO:0000313|RefSeq:XP_007198228.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) + L-cysteine(out) + Na(+)(out) = L-
CC arginine(out) + L-cysteine(in) + Na(+)(in); Xref=Rhea:RHEA:70847,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:32682, ChEBI:CHEBI:35235;
CC Evidence={ECO:0000256|ARBA:ARBA00036855};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) + L-glutamine(out) + Na(+)(out) = L-
CC arginine(out) + L-glutamine(in) + Na(+)(in); Xref=Rhea:RHEA:70835,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:32682, ChEBI:CHEBI:58359;
CC Evidence={ECO:0000256|ARBA:ARBA00036315};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) + L-histidine(out) + Na(+)(out) = L-
CC arginine(out) + L-histidine(in) + Na(+)(in); Xref=Rhea:RHEA:70839,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:32682, ChEBI:CHEBI:57595;
CC Evidence={ECO:0000256|ARBA:ARBA00036477};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) + L-leucine(out) + Na(+)(out) = L-arginine(out)
CC + L-leucine(in) + Na(+)(in); Xref=Rhea:RHEA:70831, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:32682, ChEBI:CHEBI:57427;
CC Evidence={ECO:0000256|ARBA:ARBA00036563};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) + L-lysine(out) = L-arginine(out) + L-
CC lysine(in); Xref=Rhea:RHEA:70827, ChEBI:CHEBI:32551,
CC ChEBI:CHEBI:32682; Evidence={ECO:0000256|ARBA:ARBA00036987};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) + L-methionine(out) + Na(+)(out) = L-
CC arginine(out) + L-methionine(in) + Na(+)(in); Xref=Rhea:RHEA:70843,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:32682, ChEBI:CHEBI:57844;
CC Evidence={ECO:0000256|ARBA:ARBA00035819};
CC -!- SUBUNIT: Disulfide-linked heterodimer with the amino acid transport
CC protein SLC3A2/4F2hc. {ECO:0000256|ARBA:ARBA00038768}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
CC {ECO:0000256|ARBA:ARBA00007040}.
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DR RefSeq; XP_007198227.1; XM_007198165.1.
DR RefSeq; XP_007198228.1; XM_007198166.1.
DR RefSeq; XP_007198229.1; XM_007198167.1.
DR RefSeq; XP_007198230.1; XM_007198168.1.
DR AlphaFoldDB; A0A384BG25; -.
DR STRING; 310752.A0A384BG25; -.
DR GeneID; 103019659; -.
DR KEGG; bacu:103019659; -.
DR CTD; 9057; -.
DR InParanoid; A0A384BG25; -.
DR OrthoDB; 1103451at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR002293; AA/rel_permease1.
DR PANTHER; PTHR11785; AMINO ACID TRANSPORTER; 1.
DR PANTHER; PTHR11785:SF398; Y+L AMINO ACID TRANSPORTER 2; 1.
DR Pfam; PF13520; AA_permease_2; 1.
DR PIRSF; PIRSF006060; AA_transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 48..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 78..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 538 AA; 59569 MW; 6780C43A40B8CC34 CRC64;
MEARELESHH TPTYHLIPEA SRPREEEDVS MLPQQSTETM QLKKEISLLN GVSLVVGNMI
GSGIFVSPKG VLVYTASYGL SLIIWAIGGL FSVVGALCYA ELGTTITKSG ASYAYILEAF
GGFIAFIRLW ASLLIVEPTS QAIIAITFAN YIIQPSFPTC EPPYLACRLL AAACMCLLTF
VNCAYVKWGT RVQDTFTYAK VLALIAIIVM GLVKLCQGHS EHFQDAFKGS SWDLGDLSLA
LYSALFSYSG WDTLNFVTEE IKNPERNLPL AIGISMPIVT LIYILTNVAY YTVLSISDVL
GSDAVAVTFA DQTFGMFSWT IPIAVALSCF GGLNASIFAS SRLFFVGSRE GHLPDLLSMI
HVERFTPIPA LLFNCTMTLI YLTVEDVFLL INYFSFSYWF FVGLSVAGQL YLRWKEPERP
RPLKLSLFFP IVFCICSLFL VVVPLFSDTI NSLIGIGIAL SGVPIYFLGV YLPESRRPLF
IRNVLGELLF AYHTLALCVC IYKDACTAAI TEVTQKLCFC VLTELDVAEE RQVERKTE
//
