ID A0A384BIH5_URSMA Unreviewed; 416 AA.
AC A0A384BIH5;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 03-AUG-2022, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=T-cell-specific guanine nucleotide triphosphate-binding protein 2-like {ECO:0000313|RefSeq:XP_008681960.2};
GN Name=LOC103656360 {ECO:0000313|RefSeq:XP_008681960.2};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008681960.2};
RN [1] {ECO:0000313|RefSeq:XP_008681960.2}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008681960.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. IRG family. {ECO:0000256|ARBA:ARBA00005429}.
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DR RefSeq; XP_008681960.2; XM_008683738.2.
DR KEGG; umr:103656360; -.
DR OrthoDB; 4586265at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR CDD; cd04104; p47_IIGP_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030385; G_IRG_dom.
DR InterPro; IPR007743; Immunity-related_GTPase-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR32341; INTERFERON-INDUCIBLE GTPASE; 1.
DR PANTHER; PTHR32341:SF15; RIKEN CDNA 9930111J21 GENE 1-RELATED; 1.
DR Pfam; PF05049; IIGP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51716; G_IRG; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680}.
FT DOMAIN 69..251
FT /note="IRG-type G"
FT /evidence="ECO:0000259|PROSITE:PS51716"
SQ SEQUENCE 416 AA; 46938 MW; 69817A85B82A9EA0 CRC64;
MGQSSSSTVS HTKGGDLASS FDKFFKDFKV ESKIISQETI ESIRSRLKEG DLPSAVSAIS
DALREIDNAP LNIAVTGESG TGKSTFINAL RGVGDEDEGA APTGPVETTF KRTPYKHPKF
PNVTLWDLPG TGTTNFQPHD YLEKMKFREY DFFIIISATR FKINDAQLAV AIEKMKKNFY
FVRTKVDSDL YNQKRSQPNK FNEHEILQRI RNDCVTRLQK ANVSNAQVFL VSSFELAHYD
FPSLETTLLR ELPAQKRHIF MQHLPNITEV TIDRKRDSLK QRVWLEAMKA GALATVPFMG
YISDNDVETL KDALTLYRVY FGLDDASLKI MAKDLHVSVE KLKGNLKCPH LLSIEKDDES
LGEKLLRYVE KFCSVSGGPL AAGLYFAKIY SLQNYFLETV ASDAKVLLKK GDFQRL
//
