ID A0A384BJG9_URSMA Unreviewed; 468 AA.
AC A0A384BJG9;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Nucleobindin-1 {ECO:0000256|ARBA:ARBA00020408};
GN Name=NUCB1 {ECO:0000313|RefSeq:XP_008682743.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008682743.1};
RN [1] {ECO:0000313|RefSeq:XP_008682743.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008682743.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Golgi
CC apparatus, cis-Golgi network membrane {ECO:0000256|ARBA:ARBA00004306};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004306}; Lumenal
CC side {ECO:0000256|ARBA:ARBA00004306}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the nucleobindin family.
CC {ECO:0000256|ARBA:ARBA00008063}.
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DR RefSeq; XP_008682743.1; XM_008684521.2.
DR AlphaFoldDB; A0A384BJG9; -.
DR GeneID; 103657106; -.
DR KEGG; umr:103657106; -.
DR CTD; 4924; -.
DR OrthoDB; 2881246at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR040250; Nucleobindin.
DR PANTHER; PTHR19237; NUCLEOBINDIN; 1.
DR PANTHER; PTHR19237:SF21; NUCLEOBINDIN-1; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..468
FT /note="Nucleobindin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016987863"
FT DOMAIN 248..283
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 201..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..227
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 468 AA; 54148 MW; 8B6CA87F1F843E80 CRC64;
MPSSGPRAAL VLLLPPLLLL RAVLAVPLER GAPKQESPAT ESPVSGPALL SSQDTGLYYH
RYLQEVINVL ETDGHFREKL QAANAEDIKS GKLSRELDFV SHHVRTKLDE LKRQEVSRLR
MLLKAKMDAE QEPNVQLDHL SLLKQFEHLD PQNQHTFEAR DLELLIQTAT RDLAQYDAAH
HEEFKRYEML KEHERRRYLE SLGEEQRKEA ERKLEEQQRR HREHPKVNVP GSQAQLKEVW
EELDGLDPNR FNPKTFFILH DINSDGVLDE QELEALFTKE LEKVYDPKNE EDDMREMEEE
RLRMREHVMK NVDTNQDRLV TLEEFLASTQ RKDFGDTGEG WETVEMHPAY TEDELRRFEE
ELAAREAELN AKAQRLSQET EALGRSQGRL EAQKRELQQA VLQMEQRKQQ QQGQNNPAPG
PEGQLQFHPD TDDAPVPAPA GDQKDVDPSE KKVPDQPPEL PQSDTQHL
//
