ID A0A384BKU1_URSMA Unreviewed; 721 AA.
AC A0A384BKU1;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Rho guanine nucleotide exchange factor 7 isoform X2 {ECO:0000313|RefSeq:XP_008683191.1};
GN Name=ARHGEF7 {ECO:0000313|RefSeq:XP_008683191.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008683191.1};
RN [1] {ECO:0000313|RefSeq:XP_008683191.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008683191.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}.
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DR RefSeq; XP_008683191.1; XM_008684969.2.
DR AlphaFoldDB; A0A384BKU1; -.
DR STRING; 29073.ENSUMAP00000030638; -.
DR GeneID; 103657535; -.
DR KEGG; umr:103657535; -.
DR CTD; 8874; -.
DR OrthoDB; 2879064at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01225; PH_Cool_Pix; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd12061; SH3_betaPIX; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035789; BetaPIX_SH3.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR032409; GEF6/7_CC.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR046376; PH_Cool_Pix.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46026:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7; 1.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF16523; betaPIX_CC; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16615; RhoGEF67_u1; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 81..140
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 168..348
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 370..475
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 481..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 669..710
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 481..498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 721 AA; 81489 MW; 28E28F55F556C0AE CRC64;
MKTFDANDLY QGQNFNKVLS SLVTLNKVTA DIGLGSDSVC ARPSSHRIKS FDSLGAQPSH
SRTSKLFQGQ YRSLDMTDNS NNQLVVRAKF NFQQTNEDEL SFTKGDVIHV TRVEEGGWWE
GTHNGRTGWF PSNYVREIKP SEKPVSPKSG ALKSPPKGFD TTAINKSYYN VVLQNILETE
NEYSKELQTV LSTYLRPLQT SEKLSSTNTS YLMGNLEEIC SFQQMLVQSL EECTKLPEAQ
QRVGGCFLNL MPQMKTLYLA YCANHPSAVN VLTEHSEQLG EFMETRGASS PGILVLTTGL
SRPFMRLDKY PTLLKELERH MEDYHPDRQD IQKSMTAFKN LSAQCQEVRK RKELELQILT
EAIRSWEGDD ITTLGNVVYM SQVMVQCAGS EEKNERYLLL FPNILLMLSA SPRMSGFIYQ
GKLPTTGMTI TKLEDSENHR NAFEISGSMI ERILVSCNNQ QDLHEWVDHL QKQTKVTSVG
NPTIKPHSVP SHTLPSHPIA PSSKHADSKP VPLTPAYHTL PHPSHHGTPH TTINWGPLEP
PKTPKPWSLS CLRPAPPLRP SAALCYKEDL SKSPKTMKKL LPKRKPERKP SDEEFALRKS
TAALEEDAQI LKVIEAYCTS AKTRQTLNSS SRKESAPQVL LPEEEKMIVE ETKSNGQTVI
EEKSLVDTVY ALKDEVQELR QDNKKMKKSL EEEQRARKDL EKLVRKVLKN MNDPAWDETN
L
//
