ID A0A384BLD5_URSMA Unreviewed; 399 AA.
AC A0A384BLD5;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Lymphocyte transmembrane adapter 1 {ECO:0000313|RefSeq:XP_008683372.1};
DE SubName: Full=Lymphocyte transmembrane adaptor 1 {ECO:0000313|Ensembl:ENSUMAP00000007126};
GN Name=LAX1 {ECO:0000313|Ensembl:ENSUMAP00000007126,
GN ECO:0000313|RefSeq:XP_008683372.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008683372.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000007126}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008683372.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008683372.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008683371.1; XM_008685149.1.
DR RefSeq; XP_008683372.1; XM_008685150.2.
DR STRING; 29073.ENSUMAP00000007126; -.
DR Ensembl; ENSUMAT00000008553.1; ENSUMAP00000007126.1; ENSUMAG00000005538.1.
DR GeneID; 103657739; -.
DR KEGG; umr:103657739; -.
DR CTD; 54900; -.
DR OMA; RDYINVP; -.
DR OrthoDB; 4630544at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0042169; F:SH2 domain binding; IEA:Ensembl.
DR GO; GO:0042113; P:B cell activation; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
DR GO; GO:0050868; P:negative regulation of T cell activation; IEA:Ensembl.
DR InterPro; IPR031393; LAX.
DR PANTHER; PTHR24091; LYMPHOCYTE TRANSMEMBRANE ADAPTER 1; 1.
DR PANTHER; PTHR24091:SF0; LYMPHOCYTE TRANSMEMBRANE ADAPTER 1; 1.
DR Pfam; PF15681; LAX; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|RefSeq:XP_008683372.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 39..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 234..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 399 AA; 43875 MW; 18140C194C189FC3 CRC64;
MTTDVITPTL SEIRGRTSEA RTLQVTDGSL DREKDQSNAI FSGFAGFLAI LLTTVIFYSL
WSWSKWKKQR QVPYFRVTVL PLLSLSGPRQ GAKNIYDSLP QRQEVLGRRQ SRSNRIFSTE
SLLSRNSDSL PSEPVPSQAG NALWLHRDHT PANGYAVGIY DNAAGLQICG DLSPSANYVN
VRAARDCLSI SSEDSRDYIN VPTAEEIAKA LASTNSTPVN LFALPSAQEL ELTEEKDKGY
GNASEHTSFW SPKSESDDPL NDDEDSSETS NDYVNMAGLT LETVQRKQPW MAFQCYRDYE
NVPSVPTNGN QQQVEEEVTS SNTDQEEGMT DGPGTHIQFV MQSGRFLALG EHVTCQPSAQ
SETSPIKHGG EMSNDTSSDY ENVLAVESGD MGSEQGPDT
//
