ID A0A384BLF2_URSMA Unreviewed; 1115 AA.
AC A0A384BLF2;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=LOW QUALITY PROTEIN: exportin-6 {ECO:0000313|RefSeq:XP_008683438.1};
GN Name=XPO6 {ECO:0000313|RefSeq:XP_008683438.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008683438.1};
RN [1] {ECO:0000313|RefSeq:XP_008683438.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008683438.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the exportin family.
CC {ECO:0000256|ARBA:ARBA00009466}.
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DR RefSeq; XP_008683438.1; XM_008685216.2.
DR STRING; 29073.ENSUMAP00000009784; -.
DR GeneID; 103657810; -.
DR KEGG; umr:103657810; -.
DR CTD; 23214; -.
DR OrthoDB; 169519at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005049; F:nuclear export signal receptor activity; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006611; P:protein export from nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040016; XPO6.
DR PANTHER; PTHR21452; EXPORTIN-6; 1.
DR PANTHER; PTHR21452:SF4; EXPORTIN-6; 1.
DR Pfam; PF03810; IBN_N; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 31..97
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
FT REGION 191..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1115 AA; 127733 MW; 8BC302242FC748E4 CRC64;
MASEEASLRA LEGLMTEFFH DCTTNERKRE IEELLDNFAQ QIGAWRLCLY FLSSTRNDYV
MMYSLTVFEN LINKMWLGVP SQDKMEIRSC LPKLLLAHHK TLPYFIRNKL CKVIVDIGRQ
DWPMFYHDFF TNILQLIQSP VTTPLGLXCP REDLSVARKE ELRKLLLDQV QAVLGLLTGI
LETVWDKHSV TAATPPPSPT SGESGDLLSN LLQSPSSAKL LNQPIPILDA ESEYICSLAL
ECLAHLFSWI PLSASITPSL LTTIFHFARF GCDIRARKMA SVNGSSQNCV LGQERGRLGV
LAMSCINELM SKNCVPMEFE EYLLRMFQQT FYLLQKITKD NNAHTVKSRL EELDESYIEK
FTDFLRLFVS VHLRRIESYS QFPVVEFLTL LFKYTFHQPT HEGYFSCLDI WTLFLDYLTS
KIKSRLGDKE AVLNRYKDAL VLLLTEVLNR IQFRYNQAQL EELDDETLDD DQQTEWQRYL
RQSLEVVAKV MELLPTHAFS TLFPVLQDNL EVYLGLQQFV VTSGSGHRLN ITAENDCRRL
HCSLRDLSSL LQAVGRLAEY FIGDVFAARF SDALTVVERL VKVTLYGSQI KLYNIETAVP
SVLKPDLIDV HAQSLAALQA YSHWLAQYCS EAHRQNTQQF VTLISTTMDA VTPLISTKVQ
DKLLLSACHL LVSLATTVRP VFLISIPAVQ KVFNRITDAS AQRLVDKAQV LVCRALSNIL
LLPWPNLPEN EQQWPVRSIN HASLISALSR DYRDLKPSAV TPQRKMPLDD TKVIIHQTLS
VLEDIVENIS GESTKSRQIC YQSLQESVQV SLALFPAFIH QSDVTDEMLS FFLTLFRGLR
VQMGVPFTEQ IIQTFLNMFT REQLAESILH EGSTGCRVVE KFLKILQVVV QEPGQVFKPF
LPSIISLCME QVYPIIAERP SPDVKAELFE LLFRTLHHNW RYFFKSTVLA SVQRGITEEQ
MENEPQFSAI MQAFGQSFLQ PDIHLFKQNL FYLETLNTKQ KLYHKKIFRT TMLFQFVNVL
LQVLVHKSHD LLQEEIGIAI YNMASVDFDG FFAAFLPEFL TSCDGVDANQ KNVLGRNFKM
DRDLPSFTQN VHRLVNDLRY YRLCNDSLPP GTVKL
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