ID   A0A384BLJ1_URSMA        Unreviewed;       822 AA.
AC   A0A384BLJ1;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=RAS p21 protein activator 3 {ECO:0000313|Ensembl:ENSUMAP00000028544};
GN   Name=RASA3 {ECO:0000313|Ensembl:ENSUMAP00000028544};
OS   Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=29073 {ECO:0000313|Ensembl:ENSUMAP00000028544};
RN   [1] {ECO:0000313|Ensembl:ENSUMAP00000028544}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2019) to UniProtKB.
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DR   RefSeq; XP_008683149.1; XM_008684927.1.
DR   AlphaFoldDB; A0A384BLJ1; -.
DR   STRING; 29073.ENSUMAP00000028544; -.
DR   Ensembl; ENSUMAT00000033761.1; ENSUMAP00000028544.1; ENSUMAG00000020735.1.
DR   OMA; CKEEYMA; -.
DR   OrthoDB; 24454at2759; -.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0015278; F:calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:InterPro.
DR   CDD; cd08401; C2A_RasA2_RasA3; 1.
DR   CDD; cd04010; C2B_RasA3; 1.
DR   CDD; cd13371; PH_GAP1_mammal-like; 1.
DR   CDD; cd05134; RasGAP_RASA3; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR037774; RASA3_PH.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR001562; Znf_Btk_motif.
DR   PANTHER; PTHR10194:SF53; RAS GTPASE-ACTIVATING PROTEIN 3; 1.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   Pfam; PF00779; BTK; 1.
DR   Pfam; PF00168; C2; 2.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   PRINTS; PR00402; TECBTKDOMAIN.
DR   SMART; SM00107; BTK; 1.
DR   SMART; SM00239; C2; 2.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50004; C2; 2.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR   PROSITE; PS51113; ZF_BTK; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
SQ   SEQUENCE   822 AA;  94304 MW;  AFEC0C27562BB42F CRC64;
     MSLFPPSEAK NLPTYPGPNK MRDCYCTVNL DREEVFRTKI VEKSLCPFYG EDFYCEIPRS
     FRHLSFYIFD RDVFRRDSII GKVAIQKEDL PKYHNRDTWF LLQHVDADSE VQGKVHLELR
     LSEVITDTGV VCHKLATRIL ECQGLPIVNG QCDPYATVTL AGPYRSEAKK TKVKKKTNNP
     QFDEVFYFEV TRPCSYSRKS HFDFEEEDVD KLEIRVDLWN ASNLKFGDEF LGELRVPLNV
     LRQSSSYEAW YFLQPRDNGS KSLKPGDLGS LRLNVVYTED HVFSSDYYSP LRDLLLRSAD
     VEPVSASAAH VLGEVCREKQ EAAVPLVRFF LHYGRVVPFI SAIANAEVQR TQDPNTIFRG
     NSLTSKCIDE TMKLAGMHYL HVTLKPTIEE ICQSHKSCEI DPVKLKDGEN LENNMENLRQ
     YVDRIFTVIT KSGVSCPTVM CDIFFSLREA AAKRFQDDLD VRYTAVSSFI FLRFFAPAIL
     SPNLFQLTPH HTDPQTSRTL TLISKTIQTL GSLSKSKSAS FKESYMAAFY EFFNEQKYAD
     AVKNFLDLIS SSGRRDPKSI EQPILLKEGF MIKRAQGRKR FGMKNFKKRW FRLTNHEFTY
     QKSKGDQPLC SIPIENILAV EGLEEESFKM KNMFQVIQPE RALYIQANNC VEAKAWIDVL
     TKVSQCNKKR LTVYHPSAYL NGHWLCCRAS SDTAPGCSPC TGGLPANIQL DIDGDRETER
     IYSLFNSYMS KLEKMQEACG SRSVYDGPEQ EEYSTFIIDD PQETYKTLKQ VIAGVGALEQ
     EHAQYKRDKF KKTKYGSQEH PIGDKSFQSY IRQQSETSTH SI
//