ID A0A384BMF2_URSMA Unreviewed; 690 AA.
AC A0A384BMF2;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Guanylate cyclase soluble subunit alpha-1 {ECO:0000256|ARBA:ARBA00040514};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
DE AltName: Full=Soluble guanylate cyclase large subunit {ECO:0000256|ARBA:ARBA00042184};
GN Name=GUCY1A1 {ECO:0000313|Ensembl:ENSUMAP00000022528,
GN ECO:0000313|RefSeq:XP_008683751.1, ECO:0000313|RefSeq:XP_008683752.1,
GN ECO:0000313|RefSeq:XP_040482319.1, ECO:0000313|RefSeq:XP_040482320.1,
GN ECO:0000313|RefSeq:XP_040482321.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008683752.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000022528}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008683751.1, ECO:0000313|RefSeq:XP_008683752.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008683751.1,
RC ECO:0000313|RefSeq:XP_008683752.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR RefSeq; XP_008683751.1; XM_008685529.2.
DR RefSeq; XP_008683752.1; XM_008685530.2.
DR RefSeq; XP_040482319.1; XM_040626385.1.
DR RefSeq; XP_040482320.1; XM_040626386.1.
DR RefSeq; XP_040482321.1; XM_040626387.1.
DR STRING; 29073.ENSUMAP00000022528; -.
DR Ensembl; ENSUMAT00000026706.1; ENSUMAP00000022528.1; ENSUMAG00000016481.1.
DR GeneID; 103658044; -.
DR KEGG; umr:103658044; -.
DR CTD; 2982; -.
DR OMA; NANFFGE; -.
DR OrthoDB; 2898719at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0098982; C:GABA-ergic synapse; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0008074; C:guanylate cyclase complex, soluble; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0038060; P:nitric oxide-cGMP-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0010750; P:positive regulation of nitric oxide mediated signal transduction; IEA:Ensembl.
DR GO; GO:0008217; P:regulation of blood pressure; IEA:Ensembl.
DR GO; GO:0060087; P:relaxation of vascular associated smooth muscle; IEA:Ensembl.
DR GO; GO:0098925; P:retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission; IEA:Ensembl.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR038158; H-NOX_domain_sf.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655:SF4; GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680}.
FT DOMAIN 481..608
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 426..453
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 690 AA; 77505 MW; 6D01676B4C4B61FF CRC64;
MFCTKLKDLK ITGECPLSLL APGQVPKEPG EEVAGSSESG KATLAICQDV PEKNVPRSLP
QRKTSRSRVY LHTLAESICK LIFPELERLH LALQRTLAKH QLKESRKSLE REDLEKIITD
QAIAAGVPVE IVKESLGEEL FKICYEEDEH ILGVVGGTLK DFLNSFSTLL KQSSHCQEAE
KRGRFEDASI LCLDKDHDFL NVYYFFPKRI TSLILPGIIK AAARVLYETE VEVSLLPPCF
RNDCSEFANQ PYLLYSLHIK STKPSLSPGK PQSSLVIPAS LFCKTFPFHF MFDKDLTILQ
FGNGIRRLMN RRDFQGKPNF EEYFEILTPK VNQTFSGIMA MLNMQFVVRV RRWDNSVKKS
SRVMDLKGQM IYIVESSAIL FLGSPCVDRL EDFTGRGLYL SDIPIHNALR DVVLIGEQAR
AQDGLKKRLG KLKATLEQAH QALEEEKKKT VDLLCSIFPC EVAQQLWQGQ VVQAKKFSDV
TMLFSDIVGF TAICSQCSPL QVITMLNALY TRFDRQCGEL DVYKVETIGD AYCVAGGLHK
ESDTHAVQIA LMALKMMELS DEVMSPHGEP IKMRIGLHSG SVFAGVVGVK MPRYCLFGNN
VTLANKFESC SVPRKINVSP TTYRLLKDCP GFVFTPRSRE ELPPNFPSEI PGICHFLEAY
QPVTNSKPWF QKKDVEDGNA NFLGKASGID
//
