ID   A0A384BRC0_URSMA        Unreviewed;       475 AA.
AC   A0A384BRC0;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   03-AUG-2022, sequence version 2.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Ubiquitin-conjugating enzyme E2 variant 3 isoform X1 {ECO:0000313|RefSeq:XP_008685138.2};
GN   Name=UEVLD {ECO:0000313|RefSeq:XP_008685138.2};
OS   Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008685138.2};
RN   [1] {ECO:0000313|RefSeq:XP_008685138.2}
RP   IDENTIFICATION.
RC   TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008685138.2};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_008685138.2; XM_008686916.2.
DR   AlphaFoldDB; A0A384BRC0; -.
DR   STRING; 29073.ENSUMAP00000028213; -.
DR   KEGG; umr:103659404; -.
DR   OrthoDB; 5344346at2759; -.
DR   Proteomes; UP000261680; Unplaced.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR   GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:InterPro.
DR   CDD; cd05293; LDH_1; 1.
DR   Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR   InterPro; IPR001557; L-lactate/malate_DH.
DR   InterPro; IPR022383; Lactate/malate_DH_C.
DR   InterPro; IPR001236; Lactate/malate_DH_N.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   InterPro; IPR008883; UEV_N.
DR   PANTHER; PTHR43128; L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)); 1.
DR   PANTHER; PTHR43128:SF32; UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 3; 1.
DR   Pfam; PF02866; Ldh_1_C; 1.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   Pfam; PF05743; UEV; 1.
DR   PRINTS; PR00086; LLDHDRGNASE.
DR   SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF54495; UBC-like; 1.
DR   PROSITE; PS51322; UEV; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000261680}.
SQ   SEQUENCE   475 AA;  52711 MW;  5D8A02CA59B206D8 CRC64;
     MEMEFDCEGL RRLLGKYKFR DLTVEELKNV NMFFPHFRYS MDTYVFKDSS QKDLLNFTGT
     VPVMYQGNTY NIPIRLWILD SHPFAPPICF LKPTANMGIS VGKHVDAQGR IYLPYLQNWS
     HPKSVIVGLI KEMIAKFQEE LPLYSLPSSD EARQVDLLAY IAKITEGVSD INSKNWVNHE
     HKTVNKITVV GGGELGIACT LAISAKGIAD RLVLLDLSEE TKGGVMDLDI FSLPNVEISK
     DLSASAHSKV VIFTVNSLGS SQSYLDVVQS NVDMFRALVP ALGHYSQHGV LLVASQPVEI
     MTYVTWKLSA FPVNRVIGIG CNLDSQRLQY IITTVLKAQT SGKQVWVIGE QGEDKVPTWG
     GQEEVMSPNS QVQLSNRAME LLRVKGQRSW SVGLSVADLV DSIVNDKKKV HSVSILAKGY
     YDINSEVFLS LPCIIGTSGV SEVIQSTVRE DTVTEKLQSS ASSIHGLQQQ LKLCF
//