ID A0A384BRP3_URSMA Unreviewed; 179 AA.
AC A0A384BRP3;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Glucagon {ECO:0000313|Ensembl:ENSUMAP00000016353, ECO:0000313|RefSeq:XP_008685251.1};
GN Name=GCG {ECO:0000313|Ensembl:ENSUMAP00000016353,
GN ECO:0000313|RefSeq:XP_008685251.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008685251.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000016353}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008685251.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008685251.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_008685251.1; XM_008687029.2.
DR STRING; 29073.ENSUMAP00000016353; -.
DR Ensembl; ENSUMAT00000019336.1; ENSUMAP00000016353.1; ENSUMAG00000012019.1.
DR GeneID; 103659505; -.
DR KEGG; umr:103659505; -.
DR CTD; 2641; -.
DR OMA; MNTKRNX; -.
DR OrthoDB; 5318261at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0071377; P:cellular response to glucagon stimulus; IEA:Ensembl.
DR GO; GO:0006094; P:gluconeogenesis; IEA:Ensembl.
DR GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR GO; GO:1900118; P:negative regulation of execution phase of apoptosis; IEA:Ensembl.
DR GO; GO:0090280; P:positive regulation of calcium ion import; IEA:Ensembl.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0045722; P:positive regulation of gluconeogenesis; IEA:Ensembl.
DR GO; GO:0051571; P:positive regulation of histone H3-K4 methylation; IEA:Ensembl.
DR GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
DR GO; GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
DR GO; GO:0010737; P:protein kinase A signaling; IEA:Ensembl.
DR GO; GO:0014823; P:response to activity; IEA:Ensembl.
DR Gene3D; 6.10.250.590; -; 3.
DR InterPro; IPR015550; Glucagon.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR PANTHER; PTHR11418; GLUCAGON; 1.
DR PANTHER; PTHR11418:SF0; PRO-GLUCAGON; 1.
DR Pfam; PF00123; Hormone_2; 3.
DR PRINTS; PR00275; GLUCAGON.
DR SMART; SM00070; GLUCA; 3.
DR PROSITE; PS00260; GLUCAGON; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..179
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041072138"
FT DOMAIN 53..75
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
FT DOMAIN 146..168
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
FT REGION 25..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 179 AA; 20933 MW; 4B90657220DF000A CRC64;
MKSIYFVAGL FVMLVQGSWQ RSLQDTEEKS RSFPAPQTDP LNDPDQMNED KRHSQGTFTS
DYSKYLDSRR AQDFVQWLMS TKRNKNNIAK RHDEFERHAE GTFTSDVSSY LEGQAAKEFI
AWLVKGRGRR DFPEEVAIVE ELRRRHADGS FSDEMNTVLD DLATRDFINW LLQTKITER
//
