ID A0A384BSQ7_URSMA Unreviewed; 175 AA.
AC A0A384BSQ7;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Inducible T-cell costimulator {ECO:0000256|ARBA:ARBA00019739};
GN Name=ICOS {ECO:0000313|RefSeq:XP_008685621.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008685621.1};
RN [1] {ECO:0000313|RefSeq:XP_008685621.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008685621.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Enhances all basic T-cell responses to a foreign antigen,
CC namely proliferation, secretion of lymphokines, up-regulation of
CC molecules that mediate cell-cell interaction, and effective help for
CC antibody secretion by B-cells. Essential both for efficient interaction
CC between T and B-cells and for normal antibody responses to T-cell
CC dependent antigens. Does not up-regulate the production of interleukin-
CC 2, but superinduces the synthesis of interleukin-10. Prevents the
CC apoptosis of pre-activated T-cells. Plays a critical role in CD40-
CC mediated class switching of immunoglobin isotypes.
CC {ECO:0000256|ARBA:ARBA00025344}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_008685621.1; XM_008687399.2.
DR AlphaFoldDB; A0A384BSQ7; -.
DR GeneID; 103659776; -.
DR CTD; 29851; -.
DR OrthoDB; 4570780at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031295; P:T cell costimulation; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR039943; ICOS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR20904:SF0; INDUCIBLE T-CELL COSTIMULATOR; 1.
DR PANTHER; PTHR20904; INDUCIBLE T-CELL COSTIMULATOR ICOS; 1.
DR Pfam; PF15910; V-set_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..175
FT /note="Inducible T-cell costimulator"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017021190"
FT TRANSMEM 142..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..135
FT /note="Immunoglobulin V-set"
FT /evidence="ECO:0000259|Pfam:PF15910"
SQ SEQUENCE 175 AA; 20044 MW; F11F5375CDDE1F80 CRC64;
MKSDLWYFLL FCFQVEALTG EINDSAKSEM FTFHDGGVQI LCKFSDTVWQ FKMKLWKGTE
VLCDLTKTKE SGNTESIKNP KSCQSQLSND GVSFFLNNLD SSHASYYACE LSIFDPPPFQ
KKNISREYLN VYESQTCCQL KFWLPIGCAA FVVVYIFGCV FLCWLTKKEV SIQCA
//
